The Indomitus Crusade has brought the Emperor's vengeance to thousands of star systems. The fleets and armies under the leadership of Roboute Guilliman fight for the survival of humanity against the forces of the Chaos Gods. But the traitors and heretics are not the only foe looking to destroy the rule of Terra. Xenos prey on human worlds in numbers not seen for millennia. Worst amongst them are the rampaging orks, whose migration conquests threaten to reverse the many gains of Fleet Primus. 

A great darkness has befallen the galaxy, and the armies of Chaos are rampant. To survive, humanity must retaliate and take back what they have lost. By the will of the reborn primarch, Roboute Guilliman, is the Indomitus Crusade launched - a military undertaking that eclipses all others in known history. From the Throneworld of Terra does the Avenging Son hurl his fleets, their mission the very salvation of mankind.

The Indomitus Crusade continues its war across the stars. The primarch Roboute Guilliman has finally broken through the orkish threat bedevilling the sectors near Fenris, and makes ready to push on his bid to stabilise the Imperium Sanctus—but old and bitter foes stand in his way. Kor Phaeron, the Dark Cardinal, threatens the previously stable core of the Segmentum Solar. Waves of rebellion instigated by his infiltrating priests suggest an imminent, large-scale invasion by the Word Bearers Legion. 

The paths of Roboute Guilliman and his fallen brother Mortarion bring them inexorably together on Iax. Once a jewel of the Imperium, the garden world is dying as the plans of the Lord of Death to use it as a fulcrum to drag the stellar realm of Ultramar into the warp come to deadly fruition. While Guilliman attempts to prevent the destruction of his kingdom, Mortarion schemes to bring his brother low with the Godblight, a disease created in the Cauldron of Nurgle itself, made with the power to destroy a son of the Emperor. 

The Throneworld is in turmoil, wracked by the opening of the Great Rift and the failure of the Astronomican. Inquisitor Erasmus Crowl, his mind and body ravaged by what he has seen in the Hollow Mountain, is missing, taking with him the clues to the conspiracy that has come to obsess him. Luce Spinoza, his interrogator, must choose whether to seek him out or defend her diminished realm from the many forces that still seek to destroy it. As enemies circle, Interrogator Spinoza enters a race against time to find the evidence she needs.

Uriel Ventris, newly ascended to the ranks of the Primaris, leads warriors of the Fourth Company from the Indomitus Crusade of Roboute Guilliman to a world on the frontiers of Ultramar. Once a battleground against the orks, Sycorax is now under furious assault from an enemy of ancient times – the necrons. The Ultramarines have faced these baleful xenos before, but Uriel senses the hand of a foe from his past at work on Sycorax, a tally unfinished and a debt to the Imperium finally come due. 

In the darkness beyond the galaxy, there are monsters. Some swim closer to the light, drawn by the beacon that is the Astronomican, while others stalk the Void, predators in the dark. The Carcharodons have hunted for millennia, but now they are drawn into a new blackness...the Dark City of the drukhari itself. Commorragh. For a thousand years, Chaplain Tangata Manu has searched for a relic lost under his watch: an ancient thing, once charged into the keeping of the Forgotten One himself. But at the brink of seeing his hunt fulfilled and the relic returned, it is stolen from under him.

In the city of Queen Mab, nothing is quite as it seems. Pariah, spy and Inquisitorial agent Alizebeth Bequin is all of these things and yet none of them. An enigma, even to herself, she is caught between Inquisitors Gregor Eisenhorn and Gideon Ravenor, former allies now enemies who are playing a shadow game against a mysterious and deadly foe. Coveted by the archenemy, pursued by the Inquisition, Bequin becomes embroiled in a dark plot of which she knows not her role or purpose.

Of all the Emperor’s sons who fell to Chaos, it is perhaps Magnus the Red whose tale is the most tragic. Sanctioned because of his desire for knowledge, chastised, judged, and shattered to his very elements – there is much for the Crimson King to feel vengeful for. Yet revenge is not the only thing that draws him to Terra alongside the Warmaster’s besieging armies. He seeks something, a fragment, the missing piece of himself that lies within the most impregnable place on the planet – the inner sanctum of the Imperial Palace.

Deep in Imperium Nihilus, Blood Angels Chief Librarian Mephiston and his comrades are drawn into battle with a cabal of Thousand Sons sorcerers – with worlds at stake and hidden truths threatening to overwhelm him, this is Mephiston's darkest hour. Experience a battle of psychic might in the Dark Imperium and witness Mephiston taking on his greatest challenges ever, physically, mentally and emotionally.

The Great Crusade is ending. The Emperor has returned to Terra, while Horus remains among the stars to complete the unification of humanity. As the Imperial armies fight the final battles of the age, Remembrancer Solomon Voss seeks the answer to one question—why does Sigismund, First Captain of the Imperial Fists and greatest champion of the Legions, believe that war will not end? Granted a rare audience with the master of the Templars, the answer takes Voss on a revelatory journey to a time before Sigismund became a Space Marine.

Fell times have come to the galaxy. Cadia has fallen, destroyed by the onslaught of Chaos. A Great Rift in the warp has opened, and from its depths spew daemons and the horrors of Old Night. But all hope is not lost… A hero, long absent, has returned, and with him comes the wrath of the Ultramarines reborn. Roboute Guilliman has arisen to lead the Imperium out of darkness on a crusade the likes of which has not been seen since the fabled days of the Emperor. But never before have the forces of Ruin amassed in such numbers, and nowhere is safe from despoliation. 

The galaxy is in flames. Chaos is in the ascendant across the stars. The Great Rift has split the holdings of the Imperium in twain, isolating entire sectors from the light of Holy Terra. But all hope is not lost. The Primarch Roboute Guilliman has returned from deathless sleep and appointed Commander Dante, lord of the Blood Angels, as Regent and Warden of the newly dubbed Imperium Nihilus. In the Baal system, the shattered holding of the Chapter is being rebuilt, and Dante plans the greatest campaign of his long life, to retake half an empire. 

The Officio Assassinorum safeguards the future of humanity. Its agents are the bloody-handed, secret saviours of the Imperium, killers charged with achieving the impossible...and Vindicare assassin Absolom Raithe has just been handed the most difficult assignment of his career.

Throughout the tortured galaxy, Ephrael Stern is known by many names. The Thrice-born. The Daemonifuge. The Heretic Saint. Trapped deep within Imperium Nihilus following the coming of the Great Rift, the maligned Sister of Battle fears the Imperium is no more. The God-Emperor’s light, which has guided her through centuries of strife, has too extinguished. Seemingly forsaken, Stern is bereft until a mysterious stranger arrives, offering her a new destiny. One that might yet see the Imperium saved. Stern must prove herself worthy of the God-Emperor’s grace once more.