Charlie Reade looks like a regular high school kid, great at baseball and football, a decent student. But he carries a heavy load. His mom was killed in a hit-and-run accident when he was 10, and grief drove his dad to drink. Charlie learned how to take care of himself—and his dad. Then, when Charlie is 17, he meets a dog named Radar and his aging master, Howard Bowditch, a recluse in a big house at the top of a big hill, with a locked shed in the backyard. Sometimes strange sounds emerge from it.

Rosie Daniels leaves her husband, Norman, after 14 years in an abusive marriage. She is determined to lose herself in a place where he won't find her. She'll worry about all the rest later. Alone in a strange city, she begins to make a new life, and good things finally start to happen. Meeting Bill is one, and getting an apartment is another. Still, it's hard for Rosie not to keep looking over her shoulder, and with good reason. Norman is a cop, with the instincts of a predator.

Peaceful suburbia on Poplar Street in Wentworth, Ohio, takes a turn for the ugly when four vans containing armed "regulators" terrorize the street's residents, cold-bloodedly killing anyone foolish enough to step outside their homes. Houses mysteriously transform into log cabins, and the street now ends in what looks like a child's hand-drawn Western landscape. Masterminding this sudden onslaught is the evil creature Tak, who has taken over the body of an autistic eight-year-old boy, Seth Garin.

Since his wife died, Ralph Roberts has been having trouble sleeping. Each night he wakes up a bit earlier until he's barely sleeping at all. During his late-night walks, he observes some strange things going on in Derry, Maine. He sees colored ribbons streaming from people's heads, two strange little men wandering around town after dark, and more. He begins to suspect that these visions are something more than hallucinations brought on by lack of sleep.

Even four years after the sudden death of his wife, best selling novelist Mike Noonan can't stop grieving, nor can he return to his writing. He moves into his isolated house by the lake, which becomes the site of ghostly visitations, ever-escalating nightmares, and the sudden recovery of his writing ability. What are the forces that have been unleashed here - and what do they want of Mike Noonan?