EP 125: He Treats Everything at Once. We Go One at a Time. Who's Right? (ft. Evan Hirsch)

Evan Hirsch, MD spent five years with chronic fatigue syndrome while running his own functional medicine practice. He only recovered once he found and treated every underlying cause. Today he coaches people with chronic fatigue and long COVID, and his approach is the opposite of ours. He treats everything at once and does very little testing.

Coach Kyle and Evan compare the "shotgun" and "sniper" approaches directly. They cover his Toxic Five framework, why lab tests can miss hidden toxins and infections, the problem of heavy-metal recirculation, hidden jaw infections, and why his patients often don't feel a change until around month nine.

In this episode: 00:00 Intro + Disclaimer 00:59 Welcome, and meet Evan Hirsch 02:32 Why an MD chooses to coach instead 04:43 The Toxic Five: metals, chemicals, mold, infections, nervous system 06:43 Why hormone deficiency isn't a root cause 07:39 Shotgun vs. sniper: treating everything at once 11:48 Why lab tests can miss what's really there 11:20 The few things Evan still tests 13:16 Hidden jaw infections 15:39 Supporting thyroid without prescriptions 18:16 Inside the tinctures: binders, cilantro and chlorella 19:46 The recirculation problem with DMSA 20:39 Kyle's chelation breakdown: DMPS, EDTA and ALA 23:13 Gut binders vs. systemic toxins 25:27 Why the change often shows up around month 9 30:08 Nervous system retraining and mindset 32:58 Final thoughts on Shotgun vs Sniper Methods 33:52 Evan's final advice and where to find him 35:17 Bonus: the show tunes signature + sign-off

Connect with Evan: fixyourfatigue.com Evan's show tunes: https://youtube.com/playlist?list=PLyqBhvah0nPIf2CGW7ziq0tAUXbmjtnSh&si=XWHVqEqGBsumrC2r

Longevity Centers of America: thelcoa.com | We Listen. We Test. We Heal.

This episode is for educational purposes only and is not medical advice. Talk with a qualified provider before starting any treatment.

People & Social Links

Website: https://www.thelcoa.com/longevity-unlocked-podcast/ Podcast: @longevityunlockedpod (https://www.instagram.com/longevityunlockedpod/) Greenville, SC: @thelcgreenville (https://www.instagram.com/thelcgreenville/) West Palm Beach, FL: @thelcfl's (https://www.instagram.com/thelcfl/) Dr. K on Instagram: @theosteodoc

You took the probiotic, you paid for the gut test, and you still can't go on vacation. Here's what's actually happening in there.

Kyle Hulbert and theosteodoc, Dr. Benjamin "Dr. K" Kosubevsky, sit down with Dr. Monisha Bhanote 🌟 board-certified five times over, in anatomic pathology, clinical pathology, cytopathology, integrative medicine, and culinary medicine🌟 and get into gut health:

👉 Which tests are actually validated 👉 Why interpreting a result is harder than running it 👉 What "leaky gut" really means when a pathologist explains it 👉 Why most people taking probiotics probably shouldn't be 👉 Why she almost never reaches for antibiotics or antifungals. 👉 And more!

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⏱️ CHAPTERS 00:00 Intro + Disclaimer 00:55 Five Board Certifications Explained 01:31 The Biggest Gut Health Misconception 02:32 Which Gut Tests Are Actually Validated 04:25 Differences in Gut Health Experts 04:56 Why She Doesn't Use Antibiotics or Antifungals 05:12 Where Gut Microbiome Research Actually Stands 06:21 How Do Toxins Affect Gut Health? 08:34 What Leaky Gut Actually Means 09:31 The Soldiers Analogy for Leaky Gut 11:08 Why Probiotics Are the Wrong First Move 12:08 Why Standard Parasite Tests Miss Things 12:40 [Story] The Forgotten Malaria Case 14:30 How to Detect Chronic Parasites 15:18 Should You Be On Probiotics 17:34 Fecal Matter Transplants 19:15 What Flying Does to Your Digestion 21:39 Gut Jet Lag and the 2025 Research 24:49 Constipation on Flights 22:27 Travel Brain Fog and Oxygen 23:16 Best Botanicals for Travel 23:52 Outro + Disclaimer

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🔑 KEY TAKEAWAYS - Running a gut test is the easy part... interpreting it is where most people fail, and it's why so many end up cycling through practitioner after practitioner without getting better

- "Leaky gut" is real and has a real name: increased intestinal permeability. IIP has real causes such as medications, food additives, alcohol, infections, and chronic disease

- Probiotics are not a default fix. Food sources like yogurt, kefir, sauerkraut, kimchi should be a focus, with supplements only when testing shows something is genuinely missing

- If you do take probiotic supplements, rotate the strains rather than staying on the same ones indefinitely

- Probiotic capsules likely won't survive a flight, so they're not the travel tool people think they are: magnesium bisglycinate and ginger are more practical

- Your gut microbiome runs on its own circadian clock, which is why travel disrupts digestion before you notice anything else. (This one was new to us too)

- Fecal matter transplants are early enough that screening standards aren't where blood banking landed after decades. So, worth watching, not worth rushing.

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📚 STUDIES MENTIONED Li J, et al. "Gut jet lag: how circadian rhythm disruption undermines the Chrono-Microbiota-Motility axis and induces functional constipation." Frontiers in Nutrition, 2025. https://doi.org/10.3389/fnut.2025.1678482

⚠️ ONE CORRECTION: In the episode, we say gut organisms outnumber human cells about two to one. That figure has been revised — Sender, Fuchs, and Milo (PLOS Biology, 2016) put it closer to 1:1, roughly 38 trillion bacterial cells to 30 trillion human ones. The point stands that there are a staggering number of them; the ratio is just smaller than the number that gets repeated. https://doi.org/10.1371/journal.pbio.1002533

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🔍 Relevant To Us and This Video #GutHealth #Microbiome #LongevityUnlocked #LongevityClinic #LeakyGut #GutTesting #guthealing #probiotics #guthealthtips

📲 People & Social Links Website: https://www.thelcoa.com/longevity-unlocked-podcast/ Podcast: @longevityunlockedpod (https://www.instagram.com/longevityunlockedpod/) Dr. K on Instagram: @theosteodoc Guest: Dr. Monisha Bhanote — https://www.drbhanote.com | @drbhanote

Credits Produced by: The Longevity Centers of America in collaboration with the sHealed team Filmed in Cannes, France [https://www.imdb.com/title/tt33144483/]

Everyone Has Parasites (Yes, You Too) A Longevity Doctor Explains What to Do

Your dog licks your face, your kid shares your fork, and your restaurant salad came out of a bag that says "triple washed." Here's what that actually means.

Kyle Hulbert and theosteodoc, Dr. Benjamin "Dr. K" Kosubevsky, get into parasites — who has them, where people really pick them up, which symptoms are worth paying attention to, and when testing is and isn't worth doing.

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⏱️ CHAPTERS 00:00 Intro + Disclaimer 00:46 Who Has Parasites 01:33 Symptoms of Parasites 02:48 How You Get Parasites 05:00 Types of Parasites 05:41 Misconceptions About Parasites 07:02 Parasite Treatment for Animals v. Humans 07:22 What Are the Parasite Life Cycles 07:53 How Does Parasite Testing Work 08:22 What Does Parasite Treatment Look Like 09:26 What Natural Options Are There For Parasites 10:08 How Do Parasites Affect Aging 10:34 Do Parasites Change How You Look 10:43 Parasite Prevention 11:53 Outro + Disclaimer

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🔑 KEY TAKEAWAYS - Parasitic infection is real and underdiagnosed in the US, but it's not universal — pinworm is the genuinely common one, and it's mostly a kids-and-households story - The most common household routes are unglamorous: pets on furniture, young children, and shared food and utensils - "Triple washed" is a processing description, not a sterilization claim— it reduces contamination, it doesn't eliminate it - Standard advice is NOT to re-wash pre-washed bagged greens at home — see the note below, this surprised us too - Giardia from untreated pond, lake, or stream water is one of the most common ways Americans actually get a parasite - If you have persistent GI symptoms, unexplained fatigue, or changes in stool lasting more than a week, that's a conversation with a doctor — not a reason to buy a cleanse online

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🔍 Relevant To Us and This Video #Parasites #GutHealth #LongevityUnlocked #LonevityClinic #ParasiteTesting #ParasitePurge #parasitecleanse #parasitedetox

📲 People & Social Links

Website: https://www.thelcoa.com/longevity-unlocked-podcast/ Podcast: @longevityunlockedpod (https://www.instagram.com/longevityunlockedpod/) Dr. K on Instagram: @theosteodoc

Credits

Produced by: The Longevity Centers of America Filmed by: Jackson Young (@clearviewstudios)

In this episode of Longevity Unlocked, Coach Kyle and Dr. K introduce Derma, a new all-natural PRP-based filler made entirely from your own blood. Dr. K explains how it's created, how the procedure works using a cannula for added safety, and why it avoids the chemical reactions, toxin buildup, and "pillow face" associated with synthetic fillers. They also discuss treatment areas, expected results and longevity, how Derma can be safely reversed with saline if needed, ideal candidates, pricing, and how to maximize results by pairing it with microneedling and GHK-Cu peptide therapy.

Listeners will walk away with a clearer understanding of:

• What Derma is and how it differs from traditional synthetic filler
• Why it eliminates the toxin and pillow-face risks associated with conventional filler
• How the cannula delivery system makes it one of the safest filler options available
• What areas can be treated and what results to realistically expect
• How to reverse it if you don't like the outcome
• What to stack with Derma for enhanced and longer-lasting results

This episode is a practical, honest look at what natural PRP filler can and can't do — and why it's worth considering for anyone curious about aesthetic enhancement without the chemical baggage.

• Derma is a PRP-based filler made from your own blood, eliminating synthetic chemicals, toxins, and the risk of "pillow face."
• A cannula-based technique makes vessel occlusion virtually impossible.
• Results typically last 2 to 10 months, with full effects developing over about a month.
• If needed, Derma can be safely diluted with saline instead of using chemical reversal agents.
• It's ideal for fine lines, crow's feet, under eyes, eyebrow lifts, turkey neck, hands, and post-implant scarring.
• It's not recommended for severely loose or sagging skin.
• Two treatments six weeks apart provide longer-lasting, more even results.
• For best outcomes, microneedle two weeks before treatment, wait at least three months afterward, and support collagen with GHK-Cu peptide and a quality moisturizer.

00:00 – Welcome & Introducing Derma

00:31 – What Is Derma, Exactly?

01:15 – How It's Made: Cooking PRP Into a Gel

01:50 – Why Dr. K Never Offered Filler — Until Now

02:03 – No Toxins, No Pillow Face: How Derma Is Different

02:48 – How Long Does It Last?

03:28 – What Derma Can & Can't Do: Filler vs. Botox

03:39 – The Frownies Alternative to Botox

04:07 – Treatment Areas: Eyes, Cheeks, Neck, Hands & More

04:18 – The Eyebrow Lift: A Before & After Story

04:34 – Downsides: Bruising, Soreness & the Lumpiness Factor

05:03 – Does It Actually Make You Look Younger?

05:13 – AI Face Scan Approved

05:20 – Who Is a Good Candidate?

05:47 – Who Is Not a Good Candidate

06:00 – Risk of Hitting a Vein or Nerve: How the Cannula Works

07:00 – What It Actually Feels Like Under the Skin

07:23 – What If You Hate It? How to Reverse It

07:57 – Reversing Derma vs. Reversing Traditional Filler

08:15 – When to Expect Results

08:31 – Does It Regenerate Skin From the Inside?

08:49 – Two Treatments for Best Results: The Six-Week Protocol

09:06 – Pricing: $800–$1,200 for Face Treatments

09:28 – Breast Lifts & Butt Lifts With Derma

10:07 – Skill Matters: Don't Be Anyone's First

10:47 – Setting Realistic Expectations

11:04 – What to Stack With Derma: Micro Needling & GHK-Cu

11:33 – Wrap-Up & Final Thoughts

Longevity Center Integrative, osteopathic, and regenerative healthcare — all under one roof.

580 Village Blvd #210, West Palm Beach, FL 33409

https://www.thelcfl.com/

Instagram: @thelcfl

Website: https://www.thelcoa.com/longevity-unlocked-podcast/

Podcast: @longevityunlockedpod (https://www.instagram.com/longevityunlockedpod/)

Greenville, SC: @thelcgreenville (https://www.instagram.com/thelcgreenville/)

West Palm Beach, FL: @thelcfl (https://www.instagram.com/thelcfl/)

Dr. K on Instagram: @theosteodoc

Produced by: Clearview Studio

Filmed by: Jackson Young (@clearviewstudios)

In this episode of Longevity Unlocked, Coach Kyle and Dr. K explore the science behind peptides, explaining what they are, how they work, and why they have become a major topic in longevity and biohacking. They cover key categories including healing, growth hormone, longevity, brain, immune, and metabolic peptides, separating evidence-based science from marketing claims. The discussion highlights BPC-157 and TB-500 for healing, CJC-1295, Ipamorelin, and Tesamorelin for growth hormone support, Epithalon for longevity, and Dihexa and BDNF for cognitive health. The episode also emphasizes the risks of unregulated peptide sourcing and explains why most peptides are not recommended for people under 18, with brain peptides discouraged for anyone under 25.

Listeners will walk away with a clearer understanding of:

• What peptides are and how they differ from amino acid supplements.
• Why BPC-157 and TB-500 support healing but don't repair structural damage.
• How growth hormone peptides differ and when medical oversight is needed.
• Why Epithalon stands out as a longevity peptide.
• How Dihexa and BDNF support brain function.
• Why peptide sourcing and age guidelines matter.

This episode is the most thorough, practical breakdown of peptides we've done — designed to help you understand what you're actually taking before you take it.

• Peptides are amino acid chains that trigger specific biological functions.
• BPC-157 and TB-500 support healing but do not repair structural injuries.
• Growth hormone peptides range from Ipamorelin to advanced protocols requiring medical supervision.
• Epithalon supports longevity, while Dihexa and BDNF support brain health.
• Thymosin Alpha-1 boosts immunity but may worsen active Lyme disease.
• IGF-1 LR3 carries serious risks, including low blood sugar and potential cancer concerns.
• Peptides are not recommended for people under 18, and brain peptides should be avoided under 25.
• Use only vendors with FDA-approved API sourcing and lot-specific COA testing.

00:00 – Welcome & Introduction to Peptides

00:33 – What Is a Peptide?

01:07 – Peptides vs. Amino Acid Supplements

01:20 – Major Peptide Categories

01:48 – Bioregulators Explained

02:16 – Most Requested Peptides

02:40 – BPC-157 Overview

03:06 – What BPC Can't Fix

03:30 – Angiogenesis & Healing

03:46 – When to Use BPC-157

04:10 – TB-500 & the "Wolverine Stack"

04:57 – Unregulated Peptide Marketing

05:47 – Research-Grade Sourcing Risks

06:04 – Choosing a Quality Vendor

06:46 – Compounding Pharmacies vs. Research Grade

07:24 – Pharmaceutical-Grade Peptides

08:09 – CJC-1295 & Ipamorelin Explained

08:44 – Growth Hormone Peptide Tiers

09:00 – Tesamorelin & Medical Oversight

10:19 – Sleep, Muscle & Recovery Benefits

10:44 – Epithalon & Longevity

12:05 – Klotho: A New Longevity Target

12:51 – GLP Peptides Overview

13:15 – Dihexa vs. BDNF

13:27 – Brain Stimulation vs. Healing

14:50 – Semax & Selank

15:29 – Thymosin Alpha-1

16:03 – Lyme Disease Warning

16:36 – IGF-1 LR3 Risks

17:27 – Cancer Considerations

18:46 – Age Guidelines for Peptides

19:58 – Build the Foundation First

20:04 – Final Thoughts

Longevity Center Integrative, osteopathic, and regenerative healthcare — all under one roof.

580 Village Blvd #210, West Palm Beach, FL 33409

https://www.thelcfl.com/

Instagram: @thelcfl

Website: https://www.thelcoa.com/longevity-unlocked-podcast/

Podcast: @longevityunlockedpod (https://www.instagram.com/longevityunlockedpod/)

Greenville, SC: @thelcgreenville (https://www.instagram.com/thelcgreenville/)

West Palm Beach, FL: @thelcfl (https://www.instagram.com/thelcfl/)

Dr. K on Instagram: @theosteodoc

Produced by: Clearview Studio

Filmed by: Jackson Young (@clearviewstudios)

Episode Summary In this episode of Longevity Unlocked, Coach Kyle and Dr. K explore the realities of hair restoration, beginning with Coach Kyle's personal experience with hair thinning. Dr. K explains why PRP and biologics only work on living follicles and why he prefers direct scalp injections every 3 mm over microneedling. They also discuss how MSCs can improve results.

The conversation covers realistic treatment expectations, including three monthly sessions, results that may take up to eight months, and the need for ongoing maintenance. They also highlight supportive therapies such as GHK-Cu peptides, red light laser caps, and clean, toxin-free hair care products.

Finally, they discuss DHT blockers like finasteride and why the potential risk of permanent sexual dysfunction makes them a poor choice for many people.

Listeners will walk away with a clearer understanding of:

• Why PRP and biologics only work for thinning follicles — not dead ones
• Why direct scalp injections outperform micro needling for follicle stimulation
• What a realistic treatment timeline and maintenance schedule looks like
• How adding MSCs can amplify hair restoration results
• Which adjuncts — peptides, red light caps, and clean shampoo — support scalp health
• Why DHT blockers carry risks most people aren't warned about

This episode is a no-nonsense, practical guide to understanding your hair restoration options — and knowing when to act before it's too late.

Key Takeaways

• PRP and biologics only work on living hair follicles.
• Direct injections every 3 mm are more effective than microneedling.
• Three monthly treatments are standard, with results often visible around eight months. Maintenance is required.
• MSCs enhance PRP results, while GHK-Cu supports collagen and scalp health.
• Red light laser caps improve circulation and follicle health.
• Finasteride may carry a risk of permanent sexual dysfunction.
• Clean, toxin-free shampoo reduces exposure to endocrine disruptors.
• Hair loss is driven by hormones, circulation, fascia, and genetics.

00:00 – Welcome & Today's Topic: Hair Restoration

00:37 – Coach Kyle's Personal Hair Loss Story

01:13 – Flying to Turkey for Hair Plugs?

01:45 – Dying Follicles vs. Dead Follicles: The Critical Distinction

02:39 – Why People Lose Their Hair: Theories & Causes

03:25 – Genetics & the Role They Play

03:48 – PRP Injections: How It Actually Works

04:20 – Micro Needling vs. Direct Injections

04:37 – How Many Injections & How Long It Takes

04:49 – Pain Management Options: Cryo, Laughing Gas & Sedation

05:15 – Results Timeline & Number of Treatments

05:43 – Does More Sessions Mean Better Results?

06:06 – Why Maintenance Is Non-Negotiable

06:18 – Amplifying Results With MSCs

06:30 – Men vs. Women: Any Difference in Treatment?

06:43 – Early Warning Signs You Should Book a Consultation

07:00 – Postpartum Hair Loss: A Candidate for PRP?

07:21 – Who Should Not Do This Procedure

07:52 – Adjuncts: GHK-Cu Peptide for Scalp & Collagen

08:07 – Red Light Laser Caps: Easy, Effective, Wearable

08:31 – The Truth About DHT Blockers & Finasteride

09:06 – Why Coach Kyle Would Rather Just Shave It

09:15 – Clean Shampoo & Avoiding Endocrine Disruptors

09:36 – Don't Use Your Body Wash on Your Hair

10:03 – Wrap-Up & Final Thoughts

Longevity Center Integrative, osteopathic, and regenerative healthcare — all under one roof.

580 Village Blvd #210, West Palm Beach, FL 33409

https://www.thelcfl.com/

Instagram: @thelcfl

Produced by: Clearview Studio

Filmed by: Jackson Young (@clearviewstudios)

Website: https://www.thelcoa.com/longevity-unlocked-podcast/

Podcast: @longevityunlockedpod (https://www.instagram.com/longevityunlockedpod/)

Greenville, SC: @thelcgreenville (https://www.instagram.com/thelcgreenville/)

West Palm Beach, FL: @thelcfl (https://www.instagram.com/thelcfl/)

Dr. K on Instagram: @theosteodoc