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Benjamín Labatut’s When We Cease to Understand the World electrified a global readership. A Booker Prize and National Book Award finalist, and one of the New York Times’ Ten Best Books of the Year, it explored the life and thought of a clutch of mathematicians and physicists who took science to strange and sometimes dangerous new realms. In The MANIAC, Labatut has created a tour de force on an even grander scale.

Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine.

John von Neumann was a titan of science. A Hungarian wunderkind who revolutionized every field he touched, his mathematical powers were so exceptional that Hans Bethe—a Nobel Prize-winning physicist—thought he might represent the next step in human evolution. After seeking the foundations of mathematics during his youth in Germany, von Neumann emigrated to the United States, where he became entangled in the power games of the Cold War; he designed the world's first programmable computer, invented game theory, pioneered AI and digital life, and helped create atomic bombs.

Katalin Karikó began life as a butcher’s daughter in post-war Communist Hungary. But even as a child she understood two crucial things: for those who can see it, the world is full of fascination and wonder, and whatever challenges she faced, she could overcome them with her boundless appetite for learning. Breaking Through is Karikó’s extraordinary memoir of how she achieved her dream of becoming a scientist, first in Hungary and then in the USA, and pursued her belief – despite so many telling her not to – that an elusive molecule called mRNA could transform our ability to prevent disease.