Featuring perspectives from Dr Samuel J Klempner and Dr Stephen "Fred" Divers, moderated by Dr Divers, including the following topics:

• Introduction (0:00)
• First-Line Treatment of Metastatic Gastroesophageal Cancer (1:48)
• Management of HER2-Positive Gastroesophageal Cancer (25:11)
• Neoadjuvant Therapy for Gastroesophageal Cancer (45:13)

Note to listeners: Subsequent to the recording of this symposium, the FDA approved zanidatamab in combination with chemotherapy with and without tislelizumab for HER2-positive gastric, gastroesophageal junction, or esophageal adenocarcinoma based on results from the Phase III HERIZON-GEA-01 trial.

CME information and select publications

Featuring perspectives from Ms Caroline Kuhlman, Dr Eileen M O'Reilly, Dr Philip A Philip and Ms Amanda K Wagner, moderated by Dr O'Reilly, including the following topics:

• Introduction (0:00)
• Clinical Presentation and Prognosis of Pancreatic Adenocarcinoma (PAD) (3:29)
• Recent Advances in Up-Front Treatment for Metastatic PAD (15:47)
• Selection and Sequencing of Therapy for Relapsed/Refractory Metastatic PAD (39:58)
• Novel Strategies Targeting RAS Mutations in Advanced PAD (48:20)
• Utility of Tumor Treating Fields in PAD Management (1:13:58)

CME information and select publications

Featuring perspectives from Dr David H Ilson and Dr Kohei Shitara, including the following topics:

• Introduction (0:00)
• Biomarker Evaluation in Localized and Metastatic Disease (1:49)
• Role of Immune Checkpoint Inhibitors in the Management of Gastroesophageal Cancers — Dr Ilson (7:37)
• Other Available Therapeutic Approaches — Dr Shitara (33:22)

CME information and select publications

Featuring perspectives from Dr Yelena Y Janjigian, Dr Manish A Shah and Prof Eric Van Cutsem, moderated by Dr Janjigian, including the following topics:

• Introduction (0:00)
• HER2-Targeted Approaches in Advanced Gastroesophageal Cancers — Prof Van Cutsem (2:08)
• Targeting CLDN18.2 in Advanced Gastroesophageal Cancers — Dr Shah (30:54)
• Available Immunotherapeutic Strategies for Advanced Gastroesophageal Cancers — Dr Janjigian (1:01:39)

CME information and select publications

Featuring perspectives from Dr Tanios Bekaii-Saab, Dr Stacey A Cohen and Dr Arvind Dasari, moderated by Dr Bekaii-Saab, including the following topics:

• Introduction (0:00)
• Current and Future Role of Immune Checkpoint Inhibition in the Management of Microsatellite Instability-High/Mismatch Repair Deficient Localized and Locally Advanced Colorectal Cancer (CRC) — Dr Cohen (1:45)
• Clinical Relevance and Practical Utilization of Molecular Residual Disease Analysis in CRC — Dr Dasari (34:08)
• Recent Advances in Metastatic CRC: Optimizing Immunotherapy and Other Approaches — Dr Bekaii-Saab (1:00:42)

CME information and select publications

Featuring perspectives from Dr Kristen K Ciombor and Dr John Strickler, including the following topics:

• Introduction (0:00)
• Current and Future Role of Immune Checkpoint Inhibitors in the Management of Colorectal Cancer (CRC) — Dr Ciombor (3:58)
• Other Recent Advances in CRC Management — Dr Strickler (32:57)

CME information and select publications

Featuring an interview with Prof Bernd Kasper, including the following topics:

• Case: A woman in her early 30s develops a progressing desmoid tumor in her abdomen during pregnancy(0:00)
• Case: A woman in her late 30s with a painful small desmoid tumor in her rectus abdominus undergoes cryoablation (8:04)
• Case: A woman in her late teens with recurrent desmoid tumors in her right thigh undergoes multiple resections (13:58)
• Case: A woman in her mid 70s has a desmoid tumor causing erosion in her scapular region (17:19)

CME information and select publications

Featuring perspectives from Dr Yelena Y Janjigian and Dr Samuel J Klempner, including the following topics:

• Introduction (0:00)
• Role of Anti-PD-1/PD-L1- and CLDN18.2-Directed Antibodies in the Management of Gastroesophageal Cancers — Dr Klempner (5:52)
• Management of HER2-Positive Gastroesophageal Cancers — Dr Janjigian (28:20)

CME information and select publications