• S2 EP28 – Personalized Nutrition – From One-Size-Fits-All to True Precision
    Aug 25 2025

    In this conversation, Dr. Bill Clark and Dr. Gene Brunoexplore the evolving landscape of personalized nutrition, discussing its definition, the spectrum of personalization, and the implications of emerging technologies. They emphasize the importance of scientific rigor and consumer trust in the industry, while also addressing the potential of biohacking and true precision nutrition. The discussion highlights the need for innovation and evidence-based approaches to meet the growing demand for personalized wellness solutions.


    Keywords

    personalized nutrition, precision nutrition, biohacking,nutraceuticals, health optimization, genomics, biomarkers, wellness, dietary supplements, health technology


    Takeaways

    · Personalized nutrition is about unique dietaryneeds for optimal health.

    · The spectrum of personalized nutrition rangesfrom generalized to true precision.

    · Most current personalized nutrition offeringsare not scientifically rigorous.

    · Wearable technology is enhancing thepersonalization of nutrition.

    · Biomarker-driven approaches are becoming moreaccessible and sophisticated.

    · Biohacking allows individuals to take control oftheir health but lacks regulation.

    · True precision nutrition combines various datainputs for tailored solutions.

    · Consumer demand is shifting towardsevidence-based personalized wellness.

    · The supplement industry must evolve to meetconsumer expectations for personalization.

    · Innovation and consumer trust are key to thefuture of personalized nutrition.


    Chapters

    00:00 Introduction to Personalized Nutrition

    02:55 Defining Personalized Nutrition

    06:07 The Spectrum of Personalized Nutrition

    08:53 Generalized Programs vs. Category-Based Personalization

    11:57 Lifestyle and Symptom-Based Personalization

    14:53 Biomarker Driven Personalization

    17:45 Biohacking and DIY Personalization

    18:52 Understanding Nutrigenomics and Biohacking

    21:13 The Future of Precision Nutrition

    26:13 Market Implications of Personalized Nutrition

    33:32 The Evolution of Evidence-BasedSupplementation

    Mehr anzeigen Weniger anzeigen
    38 Min.
  • S2 EP27 – Launch of NutriSelect Brand Science Accelerator
    Aug 18 2025

    In this special episode of The Bioactive Nexus, Dr. Gene Bruno interviews Dr. Bill Clark about the evolving state of the supplement industry and the launch of NutriSelect.ai, an innovative platform designed to enhance consumer trust and transparency.


    Dr. Clark shares how NutriSelect.ai is addressing industry challenges with evidence-based supplementation and personalized health technology, while also unveiling the Brand Science Accelerator — a groundbreaking program created to help supplement companies strengthen theirbrand, science, and consumer connection.


    This exclusive accelerator is now accepting applications,with only 5 brands invited to join the first cohort. Early movers will gain access to cutting-edge tools, strategy, and scientific insights to position their brand for growth in an increasingly competitive and regulated marketplace.


    If you’re ready to elevate your brand and lead the future ofsupplementation, this is the moment to step forward.


    👉 To learn more contact Dr. Bill Clark directly on LinkedIn or email at drbill@nutriselect.ai


    Keywords

    supplement industry, NutriSelect, consumer trust, AItechnology, Brand Science Accelerator, evidence-based supplementation, regulatory challenges, product evaluation, early movers, industry transformation


    Takeaways

    · The supplement industry is facing declining consumer trust.

    · NutriSelect aims to empower consumers by providing transparency.

    · There is a lack of standardized product evaluation in the industry.

    · Brands making unsupported claims will face increased scrutiny.

    · The NutriSelect app will provide objective ratings based on science.

    · Early movers in the industry will benefit from adapting to new standards.

    · The Brand Science Accelerator program helps brands improve their product efficacy.

    · Brands must invest in clinical research to remain competitive.

    · The industry is shifting towards evidence-based supplementation.

    · Consumer demand for transparency will drive industry change.


    Chapters

    00:00 Introduction to the Supplement ShakeOut

    02:26 Current Issues in the Supplement Industry

    07:20 The Role of NutriSelect in the Industry

    09:26 Opportunities for Early Movers

    10:55 The Brand Science Accelerator Program

    15:00 The Future of Supplement Brands

    19:41 Next Steps for Interested Brands

    Mehr anzeigen Weniger anzeigen
    23 Min.
  • S2 EP26 – Feeding the Brain – Nutraceuticals, Neuroplasticity & the Future of Cognitive Function
    Jul 18 2025

    In this episode of The Bioactive Nexus podcast, Dr. Bill Clark and Dr. Gene Bruno delve into the critical topic of cognitive function, particularly as it relates to aging and the growingmarket for brain health supplements. They discuss the importance of understanding cognitive function's subdomains, such as memory and attention, and explore the mechanisms of action that underpin various nutraceuticals. The conversation highlights market trends, key ingredients for cognitive support, and the significance of formulation strategies that consider consumer expectations. The episode concludes with insights into future topics, including the role of psychedelics in cognitive health and the importance of gut health for brain function.

    Keywords

    cognitive function, brain health, nutraceuticals, neuroplasticity, aging, supplements, mechanisms of action, market trends, formulation strategies, consumer expectations

    Takeaways

    · Cognitive function is crucial as we age.

    · Neuroplasticity allows the brain to reorganizeitself.

    · The nootropics market is rapidly growing.

    · Different mechanisms of action should be used informulations.

    · Realistic consumer expectations are essentialfor product success.

    · Gut health significantly impacts cognitivefunction.

    · Psychedelics are gaining attention in cognitivehealth research.

    · Formulation strategies should avoid the kitchensink approach.

    · Clinically relevant doses are necessary foreffectiveness.

    · Brain health requires a long-term commitment.

    Chapters

    00:00 Introduction to Cognitive Function and Aging

    07:16 Understanding Cognitive Function and Neuroplasticity

    12:04 Market Trends in Brain Health Supplements

    18:17 Mechanisms of Action in Cognitive Health

    20:06 Key Ingredients for Cognitive Enhancement

    21:46 Exploring Cognitive Enhancers: Lion's Mane and Ginkgo Biloba

    23:21 The Power of Caffeine and Theanine

    25:04 Omega-3s and Spermidine: Essential Nutrients for BrainHealth

    26:53 Emerging Ingredients: Uridine Monophosphate and PQQ

    28:49 The Role of Sage and Nicotinamide Riboside inCognitive Function

    30:46 Neuroprotective Polyphenols: Blueberries and Curcumin

    32:07 Formulation Strategies: Synergy and Dosing

    35:23 Navigating Nootropic Claims: Real vs. Hype

    38:56 Building Brand Loyalty Through Realistic Expectations

    41:14 Final Takeaways: The Long Game of BrainHealth

    Mehr anzeigen Weniger anzeigen
    46 Min.
  • S2 EP25 - GLP-1, Ozempic, and the Supplement Industry: Hype, Hope, or Harm? - The Bioactive Breakdown
    Jun 23 2025

    In this conversation, experts discuss the implications ofGLP-1 receptor agonists like Ozempic in the context of weight loss and the supplement industry. They explore the mechanisms of GLP-1, the importance of diet and exercise, and the challenges faced by individuals using thesemedications. The panelists emphasize the need for a comprehensive approach to obesity, including dietary changes and physical activity, while also addressingthe role of natural products and emerging research in metabolic health. They conclude with thoughts on the future of weight management and the importance of consumer education in navigating the supplement landscape.

    Please see the links below for more information on our guests’ companies.

    • Dr. Jacqueline Jacques, ND – Wellness Industry Expert, obesity specialist, vocal critic of “natural Ozempic” claimso https://www.bariatricadvantage.com/o https://www.mvpnutra.net/o https://shop.myeq.com/

    • Jim Ayres – CEO of Kelker Pharma, product development and contract manufacturing leadero https://kelkerpharma.com/

    • Dr. Luc Maes, ND – Founder of KAIBAE, expert in gut–metabolic axis, polyphenols, and microbiome scienceo https://maescenter.com/o https://www.baobabingredients.com/o https://gokaibae.com/

    • Michael Bengivenga – SVP, New Business Development Vitaworks, experienced in brand and commercial development in the supplement spaceo https://vitaworksusa.com/

    Mehr anzeigen Weniger anzeigen
    1 Std. und 12 Min.
  • S2 EP24 - The 12 Hallmarks of Aging & Nutraceuticals - The Bioactive Insight
    Jun 3 2025

    In this conversation, Dr. Gene Bruno and Dr. Bill Clark explore the twelve hallmarks of aging, discussing how each hallmark impacts health and longevity. They delve into the role of nutraceuticals in addressing these hallmarks, emphasizing the importance of genomic stability, telomere length, epigenetic alterations, and more. The discussion highlights the interconnectedness of these factors and their implications for maintaining health as we age.

    Mehr anzeigen Weniger anzeigen
    1 Std. und 2 Min.
  • S2 EP23 - Sexual Dysfunction & Supplements - The Bioactive Insight
    Apr 29 2025

    In this episode, Dr. Gene and Dr. Bill discuss the multifaceted topic of sexual dysfunction and the role of various supplements in addressing it. They explore the prevalence of sexual dysfunction, the importance of a holistic approach that includes diet, exercise, and emotional health, and delve into specific supplements such as amino acids, botanicals, and hormones. The conversation highlights emerging research on ingredients like black ginger and the significance of using standardized, effective products for optimal results.

    Mehr anzeigen Weniger anzeigen
    58 Min.
  • S2 EP22 - Healthy Aging - The Bioactive Insight
    Mar 23 2025

    In this episode, Dr. Bill and Dr. Gene discuss the critical topic of healthy aging, exploring various aspects such as immune function, antioxidants, inflammation, and metabolic processes. They delve into the importance of dietary supplements and nutraceuticals in promoting longevity and overall wellness. The conversation highlights key ingredients like vitamin D, omega-3 fatty acids, curcumin, creatine, magnesium, and spermidine, emphasizing their roles in enhancing health as we age. The episode concludes with insights into emerging trends and future directions in the field of healthy aging.

    Mehr anzeigen Weniger anzeigen
    52 Min.
  • S2 EP21 - Hepatotoxicity in Dietary Supplements & Botanicals – Fact or Fiction - The Bioactive Breakdown
    Mar 23 2025

    In this deep dive conversation in The Bioactive Breakdown series, Dr. Bill, Dr. Gene and expert guests discuss the topic of hepatotoxicity in dietary supplements, particularly focusing on the implications of recent studies and media reports. They emphasize the importance of understanding the difference between correlation and causation, the challenges of self-reported dietary surveys, and the need for consumer awareness regarding supplement safety. The discussion also highlights the significance of clinical research in assessing liver health and the role of reputable brands in ensuring product safety and efficacy.

    Mehr anzeigen Weniger anzeigen
    56 Min.