Ep. 07: Use of T cell receptors (TCR’s) as immunotherapy against cancer
Artikel konnten nicht hinzugefügt werden
Der Titel konnte nicht zum Warenkorb hinzugefügt werden.
Der Titel konnte nicht zum Merkzettel hinzugefügt werden.
„Von Wunschzettel entfernen“ fehlgeschlagen.
„Podcast folgen“ fehlgeschlagen
„Podcast nicht mehr folgen“ fehlgeschlagen
Ep. 07: Use of T cell receptors (TCR’s) as immunotherapy against cancer
-
Gesprochen von:
-
Von:
Über diesen Titel
In this episode we interview Dr. Johanna Olweus and Dr. Morten Milek Nielsen from University of Oslo about the use of T cell receptors (TCR’s) as immunotherapy against cancer.
Dr. Olweus’s group has been speadheading identifying TCRs that are specific for minute mutations in cancer cells, that can be used in adoptive T-cell-based therapies. We talk about what the therapy entails, how TCRs are discovered and go through several papers her group has published recently on using TCR-based therapies against leukemia.
The articles discussed are:
- “Induction of neoantigen-reactive T cells from healthy donors” (link: https://pubmed.ncbi.nlm.nih.gov/31101906/)
- “T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes” (Link: https://www.nature.com/articles/s41587-021-01089-x)
- “A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo” (Link: https://www.nature.com/articles/s43018-023-00642-8)
- “A systematic safety pipeline for selection of T-cell receptors to enter clinical use” (Link: https://pubmed.ncbi.nlm.nih.gov/37607971/)
You can read more about Dr. Olweus research group here: https://www.ous-research.no/olweus/