Something insidious has arrived - right in the heartland of our nation.
Dr. Lauren Hale, a new hospital resident, is nearly killed by a raving mad emergency room patient, in a senseless, unprovoked attack.
Officer David Olson, veteran cop and former Marine, returns from a father-son camping trip to discover that his ex-wife has vanished under bizarre circumstances and his police department is on the verge of collapse.
Jack and Emma Harper, a young, upwardly mobile couple, find their hip city neighborhood rapidly descending into madness.
Dr. Eugene Chang, a research scientist for a major pharmaceutical company makes a shocking discovery that might explain the spreading wave of illness and violence gripping the city.
Eric Larsen, leader of a top-secret, rapid-response unit, circles high above the Midwest, in an unmarked military transport. Mission still unknown, his team waits to parachute into the night.
Within 24 hours, complete strangers from different walks of life will be forced to join together to survive the living nightmare that has been unleashed on their city - and their country.
This is their story.
Welcome to the hot zone!