Cliff Hubbard is a huge loser. Literally. His nickname at Happy Valley High School is Neanderthal because he's so enormous - 6'6" and 250 pounds to be exact. Life in his trailer-park home has gone from bad to worse ever since his older brother's suicide. There's no one Cliff hates more than the nauseatingly cool quarterback Aaron Zimmerman. Then Aaron returns after a near-death experience with a bizarre claim: while he was unconscious he saw God, who gave him a list of things to do to make Happy Valley High suck less. And God said there's only one person who can help: Neanderthal.
Ezra Slevin is an anxious, neurotic insomniac who spends his nights questioning his place in the universe and his days obsessing over Imogen, a nerdy girl with gigantic eyebrows and a heart of gold. For weeks, Ezra has been working up the courage to invite Imogen to prom. The only problem is Imogen's protective best friend, Wynonna Jones. Wynonna has blue hair, jams to 80s rock, and has made a career out of tormenting Ezra for as long as he can remember. Then, on the night of a total solar eclipse, something strange happens to Ezra and Wynonna - and they wake up in each other's bodies.