Access the mentioned course ‘Antipsychotic Induced Weight Gain and Metabolic Syndrome (MetS)’ here:

https://psychscene.co/4a62kQa

In this episode Consultant Psychiatrist, Dr Sanil Rege, explores the complex neurobiology of appetite regulation, diving deep into the nuances of the brain-gut-microbiome system.

Based on a recent New England Journal of Medicine (NEJM) review titled “The Physiology of Hunger,” the discussion examines hunger not as a matter of willpower, but as a sophisticated interaction between the brain, gut, and microbiome.

This podcast provides clinicians with a pathophysiological framework for differentiating between energy balance systems, reward-based drives, and microbial metabolites to better manage obesity, anorexia nervosa, and the cautious implementation of GLP-1 receptor agonists.

To get access to more material like this plus over 150 hours of interactive CPD education on psychiatry, check out The Academy using the link below:

https://psychscene.co/4t8d6gy

#HungerPhysiology #Neuroscience #MetabolicHealth

To access the full episode and over 150+ hours of cutting-edge, interactive courses on Psychiatry subscribe to The Academy: https://psychscene.co/4qfNAny

In this episode, Dr Sanil Rege looks at treatment refractory mood disorders through a psychodynamic lens using a naturalistic study from the Austen Riggs Centre.

A subset of what most see as Treatment-Resistant Depression (TRD) isn't just pharmacological non-response; it's depression embedded within personality organisation, trauma-related aspects, attachment, and unconscious patterns.

This podcast provides clinicians with a psychodynamic perspective to understand how clinical refractoriness to standard pharmacotherapy can be sustained by meaning, defences, and relational patterns, not just neurotransmitters.

To access all episodes plus 150+ hours of advanced psychiatric education, join the Academy today. Get access here:

https://www.academy.psychscene.com/

In this episode, we explore a groundbreaking 2025 Neuron paper that reframes how sleep is generated in the brain, and why we sleep at all.

Instead of a single “sleep centre,” sleep emerges from a distributed network embedded within motor and autonomic circuits. The authors also propose a unifying “catecholamine hypothesis” explaining sleep’s restorative functions across brain, immune, and metabolic systems.

We break down what this means for clinicians, how it updates classic models of sleep–wake regulation, and why dysfunction in these systems manifests across psychiatry.

To access all episodes of this podcast plus 150+ hours of advanced psychiatric education, join the Academy today. Get access here:

https://www.academy.psychscene.com/

To access all episodes plus 150+ hours of advanced psychiatric education join the Academy today. Get access here: https://www.academy.psychscene.com/

Why is Alzheimer’s disease more common in women?

In this episode, we break down what current research reveals about sex differences in Alzheimer’s biology — including hormonal changes, tau progression, genetics, and how women often compensate on early cognitive testing, delaying diagnosis.

We also discuss how these differences shape clinical assessment, treatment responses to emerging anti-amyloid therapies, and why midlife risk modification is especially important.

Key Points

• Women show faster tau accumulation once amyloid appears.
• Cognitive compensation can lead to later diagnosis in women.
• Estrogen decline at menopause influences inflammation, synaptic resilience, and neuroprotection.
• APOE-ε4 confers greater Alzheimer’s risk in women.
• Sex-specific risk factors require tailored prevention and assessment.

To access all episodes plus 150+ hours of advanced psychiatric education join the Academy today. Get access here: https://www.academy.psychscene.com/