What happens when a 200-year-old safety-net hospital decides it's had enough of losing revenue to insurance denials and uses AI to fight back? The answer may change how you think about the intersection of clinical care and financial sustainability.

In this episode, we sit down with Jani Rad, Dr. Kito Lord, and Robin Clanton from Regional One Health in Memphis, Tennessee. Together, they walk us through how a historically under-resourced hospital became an unlikely AI innovator — starting not with flashy technology, but with a simple question: can we just see our own data? From breaking down departmental silos to deploying AI that identifies payer denial patterns, generates appeals in bulk, and surfaces the big-picture revenue opportunities that encounter-by-encounter worklists will always miss — this team is actively building and testing a solution that directly bridges the gap between clinical documentation, finance, and patient outcomes.

What You Will Discover:

[00:00] Intro

[00:52] Meet the Regional One Health Team

[03:24] Data as the Starting Point

[04:17] The Physician Advisor Program

[06:00] First Tiptoe into AI

[08:56] Seeing the Big Picture

[10:00] From Data to Action

[11:39] AI Checks and Balances

[13:26] The AI Arms Race

[14:28] Negotiating Denials at Scale

[18:16] The Why Behind the Work

Connect with us:

Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

🔗Website - https://www.junaidkalia.com/

📹YouTube - https://www.youtube.com/@junaidkaliamd

Dr. Harvey Castro, ER Physician, #DrGPT™

💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

🔗Website - https://www.harveycastromd.com/

📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

Edward Marx, CEO, Advisor

💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

🔗Website - https://www.marxadvisory.com/

📹YouTube - https://www.youtube.com/@EdwardMarx

Special Guest:

Jani Rad, CEO, Regional One Health Solutions

💼LinkedIn - https://www.linkedin.com/in/janirad/

Kito Lord, MD, MBA, CHCQM-PHYADV

💼LinkedIn - https://www.linkedin.com/in/kito-lord-md-mba-chcqm-phyadv-0b2a33a6/

Learn more about Regional One Health

🔗 https://www.regionalonehealth.org/

Visit our website:

https://signalandsymptoms.com/

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Why do brilliant healthcare products fail before they ever reach patients? Sally Ann Frank, who leads Microsoft's worldwide strategy for health startups, exposes the fatal mistake and her proven protocol to avoid it.

In this episode, Sally Ann Frank, Global Lead for Health & Life Sciences at Microsoft for startups, breaks down her proven Startup Protocol framework to achieve healthcare AI startup success in an agentic AI era. Drawing from her work with hundreds of early-stage companies, Sally emphasizes the critical mistake first-time founders make: investing all their energy in building a great product without doing customer discovery to prove anyone will actually pay for it. As AI agents transform healthcare delivery, she argues the conversation must shift from talking about AI capabilities to obsessively documenting the tangible value it creates—whether that's saving clinician time, improving patient outcomes, or streamlining administrative workflows.

This episode provides Sally's tactical playbook for documenting value so convincingly that doing nothing becomes your customer's riskiest choice. From ideation to scale, her framework delivers the strategic clarity founders need to transform breakthrough ideas into fundable, sustainable businesses.

What You Will Discover:

- Sally Ann Frank: Her Mission In Action

- Why Startups Fail Before Launch

- How to Document End-User Value in Agentic AI era

- Who Validates Value Before Scaling

- The Unicorn Protocol

- The No Free Pilots Rule

- The Founder Mindset that Wins

- Your Biggest Competitor: Customers Doing Nothing

- A No Is Never Final

Referenced in the show:

🖇️ "The Start Up Protocol: A Guide for Digital Health Startups to Bypass Pitfalls and Adopt Strategies That Work" by Sally Ann Frank – https://www.amazon.com/Startup-Protocol-Startups-Pitfalls-Strategies/dp/103263944X/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1699382769&sr=8-8

🖇️ “The Unicorn Protocol: Digital Health Unicorns, How They Got There and What You Can Learn From Them” – https://www.amazon.com/Unicorn-Protocol-Digital-Health-Unicorns/dp/1032711019/?_encoding=UTF8&pd_rd_w=G2PgE&content-id=amzn1.sym.0fb2cce1-1ca4-439a-844b-8ad0b1fb77f7&pf_rd_p=0fb2cce1-1ca4-439a-844b-8ad0b1fb77f7&pf_rd_r=135-3915937-9293427&pd_rd_wg=HIDM6&pd_rd_r=dfd48b8a-14cb-42ef-98fc-b91d305d282c&ref_=aufs_ap_sc_dsk

Connect with us:

Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

🔗Website - https://www.junaidkalia.com/

📹YouTube - https://www.youtube.com/@junaidkaliamd

Dr. Harvey Castro, ER Physician, #DrGPT™

💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

🔗Website -

Healthcare is at a critical crossroads where clinicians are increasingly sidelined by administrative weight and third-party interests. The path forward isn't just surviving a broken system—it’s reclaiming our roles as primary stakeholders and system architects through a unified, "Doctor-to-Doctor" movement.

Joining us to lead this conversation is Dr. Kianor Shah, a Southern California-based oral surgeon with 20 years of clinical experience and founder of the Global Summit Institute. Dr. Shah argues that the integration of medicine and dentistry is the next frontier of patient care, with AI serving as the "divine tool" to bridge these historical silos. By leveraging predictive analysis and peer-to-peer collaboration, we can move beyond the administrative burdens that cause burnout and return our focus to clinical excellence. This mission culminates in the 2026 Global Medical Dental AI Summit in London, a landmark effort to set rigorous, doctor-led standards for AI implementation.

Together, we explore how transitioning from a service-provider mindset to a stakeholder mindset allows us to get around industry challenges and restore the oral-systemic health connection.

What You Will Discover:

- On Building the Doctor-to-Doctor movement

- The Entrepreneurial Mindset

- Bridging the Medical-Dental Gap

- 2026 Global Medical Dental AI Summit

- The Strategic Formula (0.5%) for Healthcare Transformation

- Does a 3-5 Year Timeline Matter for Physician Leadership?

- AI as the Unifying Catalyst, Not the End Goal

About the Conference:

2026 Global Medical Dental AI Summit

📍 Leonardo Royale Hotel, London Tower Bridge

📅 May 14-16, 2026

🎤 100+ speakers | 3 tracks (Medical, Dental, Business) | 700 attendees

Exclusive offer for Signals & Symptoms listeners:

Use the discount code VIP20 for a special offer

🔗 https://top100doc.com/london/

Connect with us:

Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

🔗Website - https://www.junaidkalia.com/

📹YouTube - https://www.youtube.com/@junaidkaliamd

Dr. Harvey Castro, ER Physician, #DrGPT™

💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

🔗Website - https://www.harveycastromd.com/

📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

Edward Marx, CEO, Advisor

💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

🔗Website - https://www.marxadvisory.com/

📹YouTube - https://www.youtube.com/@EdwardMarx

Special Guest:

Kianor Shah DMD, MBS, Founder, Global Summits Institute

💼LinkedIn -