Today’s clip is from episode 149 of the podcast, with Alana Karen.

This conversation explores the evolving landscape of technology, particularly in Silicon Valley, focusing on the cultural shifts due to mass layoffs, the debate over remote work, and the impact of AI on job roles and priorities. The discussion highlights the importance of adapting to these changes and preparing for the future by developing complex skills that AI cannot easily replicate.

Get the full discussion here!

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• Intro to Bayes and Advanced Regression courses (first 2 lessons free)

Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work !

Chapters:

11:37 The Hard Tech Era
21:08 The Shift in Tech Work Culture
28:49 AI's Impact on Job Security and Work Dynamics
34:33 Adapting to AI: Skills for the Future
45:56 Understanding AI Models and Their Limitations
47:25 The Importance of Diversity in AI Development
54:34 Positioning Technical Talent for Job Security
57:58 Building Resilience in Uncertain Times
01:06:33 Recognizing Diverse Ambitions in Career Progression
01:12:51 The Role of Managers in Employee Retention
01:26:55 Solving Complex Problems with AI and Innovation

Thank you to my Patrons for making this episode possible!

Links from the show:

• Alana's latest book (Use code BAYESIAN for 10% off + a free interview preparation download PDF)
• Alana’s Substack
• Alana on Linkedin
• Alana on Instagram
• The Obstacle Is the Way – The Timeless Art of Turning Trials into Triumph
• Courage Is Calling – Fortune Favours the Brave

Today’s clip is from episode 148 of the podcast, with Scott Berry.

In this conversation, Alex and Scott discuss emphasizing the shift from frequentist to Bayesian approaches in clinical trials.

They highlight the limitations of traditional trial designs and the advantages of adaptive and platform trials, particularly in the context of COVID-19 treatment.

The discussion provides insights into the complexities of trial design and the innovative methodologies that are shaping the future of medical research.

Get the full discussion here!

• Join this channel to get access to perks: https://www.patreon.com/c/learnbayesstats

• Intro to Bayes Course (first 2 lessons free): https://topmate.io/alex_andorra/503302

• Advanced Regression Course (first 2 lessons free): https://topmate.io/alex_andorra/1011122

Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work at https://bababrinkman.com/ !

• Support & get perks!

• Proudly sponsored by PyMC Labs. Get in touch and tell them you come from LBS!

• Intro to Bayes and Advanced Regression courses (first 2 lessons free)

Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work !

Chapters:

13:16 Understanding Adaptive and Platform Trials

25:25 Real-World Applications and Innovations in Trials

34:11 Challenges in Implementing Bayesian Adaptive Trials

42:09 The Birth of a Simulation Tool

44:10 The Importance of Simulated Data

48:36 Lessons from High-Stakes Trials

52:53 Navigating Adaptive Trial Designs

56:55 Communicating Complexity to Stakeholders

01:02:29 The Future of Clinical Trials

01:10:24 Skills for the Next Generation of Statisticians

Thank you to my Patrons for making this episode possible!

Yusuke Saito, Avi Bryant, Giuliano Cruz, Tradd Salvo, William Benton, James Ahloy, Robin Taylor,, Chad Scherrer, Zwelithini Tunyiswa, Bertrand Wilden, James Thompson, Stephen Oates, Gian Luca Di Tanna, Jack Wells, Matthew Maldonado, Ian Costley, Ally Salim, Larry Gill, Ian Moran, Paul Oreto, Colin Caprani, Colin Carroll, Nathaniel Burbank, Michael Osthege, Rémi Louf, Clive Edelsten, Henri Wallen, Hugo Botha, Vinh Nguyen, Marcin Elantkowski, Adam C. Smith, Will Kurt, Andrew Moskowitz, Hector Munoz, Marco Gorelli, Simon Kessell, Bradley Rode, Patrick Kelley, Rick Anderson, Casper de Bruin, Michael Hankin, Cameron Smith, Tomáš Frýda, Ryan Wesslen, Andreas Netti, Riley King, Yoshiyuki Hamajima, Sven De Maeyer, Michael DeCrescenzo, Fergal M, Mason Yahr, Naoya Kanai, Aubrey Clayton, Omri Har Shemesh, Scott Anthony Robson, Robert Yolken, Or Duek, Pavel Dusek, Paul Cox, Andreas Kröpelin, Raphaël R, Nicolas Rode, Gabriel Stechschulte, Arkady, Kurt TeKolste, Marcus Nölke, Maggi Mackintosh, Grant Pezzolesi, Joshua Meehl, Javier Sabio, Kristian Higgins, Matt Rosinski, Luis Fonseca, Dante Gates, Matt Niccolls, Maksim Kuznecov, Michael Thomas, Luke Gorrie, Cory Kiser, Julio, Edvin Saveljev, Frederick Ayala, Jeffrey Powell, Gal Kampel, Adan Romero, Blake Walters, Jonathan Morgan, Francesco Madrisotti, Ivy Huang, Gary Clarke, Robert Flannery, Rasmus Hindström, Stefan, Corey Abshire, Mike Loncaric, Ronald Legere, Sergio Dolia, Michael Cao, Yiğit Aşık, Suyog Chandramouli, Guillaume Berthon, Avenicio Baca, Spencer Boucher, Krzysztof Lechowski, Danimal, Jácint Juhász, Sander and Philippe.

Links from the show:

• Berry Consultants
• Scott's podcast
• LBS #45 Biostats & Clinical Trial Design, with Frank Harrell

Proudly sponsored by PyMC Labs, the Bayesian Consultancy. Book a call, or get in touch!

• My Intuitive Bayes Online Courses
• 1:1 Mentorship with me

Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work!

Visit our Patreon page to unlock exclusive Bayesian swag ;)

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Takeaways:

• Epidemiology focuses on health at various scales, while biology often looks at micro-level details.
• Bayesian statistics helps connect models to data and quantify uncertainty.
• Recent advancements in data collection have improved the quality of epidemiological research.
• Collaboration between domain experts and statisticians is essential for effective research.
• The COVID-19 pandemic has led to increased data availability and international cooperation.
• Modeling infectious diseases requires understanding complex dynamics and statistical methods.
• Challenges in coding and communication between disciplines can hinder progress.
• Innovations in machine learning and neural networks are shaping the future of epidemiology.
• The importance of understanding the context and limitations of data in research.

Chapters:

00:00 Introduction to Bayesian Statistics and Epidemiology

03:35 Guest Backgrounds and Their Journey

10:04 Understanding Computational Biology vs. Epidemiology

16:11 The Role of Bayesian Statistics in Epidemiology

21:40 Recent Projects and Applications in Epidemiology

31:30...

Proudly sponsored by PyMC Labs, the Bayesian Consultancy. Book a call, or get in touch!

• Intro to Bayes Course (first 2 lessons free)
• Advanced Regression Course (first 2 lessons free)

Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work!

Visit our Patreon page to unlock exclusive Bayesian swag ;)

Takeaways:

• Marketing analytics is crucial for understanding customer behavior.
• PyMC Marketing offers tools for customer lifetime value analysis.
• Media mix modeling helps allocate marketing spend effectively.
• Customer Lifetime Value (CLV) models are essential for understanding long-term customer behavior.
• Productionizing models is essential for real-world applications.
• Productionizing models involves challenges like model artifact storage and version control.
• MLflow integration enhances model tracking and management.
• The open-source community fosters collaboration and innovation.
• Understanding time series is vital in marketing analytics.
• Continuous learning is key in the evolving field of data science.

Chapters:

00:00 Introduction to Will Dean and His Work

10:48 Diving into PyMC Marketing

17:10 Understanding Media Mix Modeling

25:54 Challenges in Productionizing Models

35:27 Exploring Customer Lifetime Value Models

44:10 Learning and Development in Data Science

Thank you to my Patrons for making this episode possible!

Yusuke Saito, Avi Bryant, Ero Carrera, Giuliano Cruz, Tim Gasser, James Wade, Tradd Salvo, William Benton, James Ahloy, Robin Taylor,, Chad Scherrer, Zwelithini Tunyiswa, Bertrand Wilden, James Thompson, Stephen Oates, Gian Luca Di Tanna, Jack Wells, Matthew Maldonado, Ian Costley, Ally Salim, Larry Gill, Ian Moran, Paul Oreto, Colin Caprani, Colin Carroll, Nathaniel Burbank, Michael Osthege, Rémi Louf, Clive Edelsten, Henri Wallen, Hugo Botha, Vinh Nguyen, Marcin Elantkowski, Adam C. Smith, Will Kurt, Andrew Moskowitz, Hector Munoz, Marco Gorelli, Simon Kessell, Bradley Rode, Patrick Kelley, Rick Anderson, Casper de Bruin, Philippe Labonde, Michael Hankin, Cameron Smith, Tomáš Frýda, Ryan Wesslen, Andreas Netti, Riley King, Yoshiyuki Hamajima, Sven De Maeyer, Michael DeCrescenzo, Fergal M, Mason Yahr, Naoya Kanai, Steven Rowland, Aubrey Clayton, Jeannine Sue, Omri Har Shemesh, Scott Anthony Robson, Robert Yolken, Or Duek, Pavel Dusek, Paul Cox, Andreas Kröpelin, Raphaël R, Nicolas Rode, Gabriel Stechschulte, Arkady, Kurt TeKolste, Gergely Juhasz,...

Proudly sponsored by PyMC Labs, the Bayesian Consultancy. Book a call, or get in touch!

• Intro to Bayes Course (first 2 lessons free)
• Advanced Regression Course (first 2 lessons free)

Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work!

Visit our Patreon page to unlock exclusive Bayesian swag ;)

Takeaways:

• Bayesian deep learning is a growing field with many challenges.
• Current research focuses on applying Bayesian methods to neural networks.
• Diffusion methods are emerging as a new approach for uncertainty quantification.
• The integration of machine learning tools into Bayesian models is a key area of research.
• The complexity of Bayesian neural networks poses significant computational challenges.
• Future research will focus on improving methods for uncertainty quantification. Generalized Bayesian inference offers a more robust approach to uncertainty.
• Uncertainty quantification is crucial in fields like medicine and epidemiology.
• Detecting out-of-distribution examples is essential for model reliability.
• Exploration-exploitation trade-off is vital in reinforcement learning.
• Marginal likelihood can be misleading for model selection.
• The integration of Bayesian methods in LLMs presents unique challenges.

Chapters:

00:00 Introduction to Bayesian Deep Learning

03:12 Panelist Introductions and Backgrounds

10:37 Current Research and Challenges in Bayesian Deep Learning

18:04 Contrasting Approaches: Bayesian vs. Machine Learning

26:09 Tools and Techniques for Bayesian Deep Learning

31:18 Innovative Methods in Uncertainty Quantification

36:23 Generalized Bayesian Inference and Its Implications

41:38 Robust Bayesian Inference and Gaussian Processes

44:24 Software Development in Bayesian Statistics

46:51 Understanding Uncertainty in Language Models

50:03 Hallucinations in Language Models

53:48 Bayesian Neural Networks vs Traditional Neural Networks

58:00 Challenges with Likelihood Assumptions

01:01:22 Practical Applications of Uncertainty Quantification

01:04:33 Meta Decision-Making with Uncertainty

01:06:50 Exploring Bayesian Priors in Neural Networks

01:09:17 Model Complexity and Data Signal

01:12:10 Marginal Likelihood and Model Selection

01:15:03 Implementing Bayesian Methods in LLMs

01:19:21 Out-of-Distribution Detection in LLMs

Thank you to my Patrons for making this episode possible!

Yusuke Saito, Avi Bryant, Ero Carrera, Giuliano Cruz, James Wade, Tradd Salvo, William Benton, James Ahloy, Robin Taylor,, Chad Scherrer,...

• Sign up for Alex's first live cohort, about Hierarchical Model building!

Proudly sponsored by PyMC Labs, the Bayesian Consultancy. Book a call, or get in touch!

• Intro to Bayes Course (first 2 lessons free)
• Advanced Regression Course (first 2 lessons free)

Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work!

Visit our Patreon page to unlock exclusive Bayesian swag ;)

Takeaways:

• Bayesian mindset in psychology: Why priors, model checking, and full uncertainty reporting make findings more honest and useful.
• Intermittent fasting & cognition: A Bayesian meta-analysis suggests effects are context- and age-dependent – and often small but meaningful.
• Framing matters: The way we frame dietary advice (focus, flexibility, timing) can shape adherence and perceived cognitive benefits.
• From cravings to choices: Appetite, craving, stress, and mood interact to influence eating and cognitive performance throughout the day.
• Define before you measure: Clear definitions (and DAGs to encode assumptions) reduce ambiguity and guide better study design.
• DAGs for causal thinking: Directed acyclic graphs help separate hypotheses from data pipelines and make causal claims auditable.
• Small effects, big implications: Well-estimated “small” effects can scale to public-health relevance when decisions repeat daily.
• Teaching by modeling: Helping students write models (not just run them) builds statistical thinking and scientific literacy.
• Bridging lab and life: Balancing careful experiments with real-world measurement is key to actionable health-psychology insights.
• Trust through transparency: Openly communicating assumptions, uncertainty, and limitations strengthens scientific credibility.

Chapters:

10:35 The Struggles of Bayesian Statistics in Psychology

22:30 Exploring Appetite and Cognitive Performance

29:45 Research Methodology and Causal Inference

36:36 Understanding Cravings and Definitions

39:02 Intermittent Fasting and Cognitive Performance

42:57 Practical Recommendations for Intermittent Fasting

49:40 Balancing Experimental Psychology and Statistical Modeling

55:00 Pressing Questions in Health Psychology

01:04:50 Future Directions in Research

Thank you to my Patrons for...