In this episode of Current Vet, Dr Lottie talks about Jaagsiekte, also known as Ovine Pulmonary Adenocarcinoma (OPA)

Find us on TikTok & Instagram: @veterinaryvista

Timeline:

• 00:00 Intro
• 00:56 Case
• 03:48 Aetiology & Pathogenesis
• 06:25 Clinical Signs
• 08:28 Diagnosis
• 12:34 Treatment
• 16:53 Current Research
• 18:09 Key Points
• 19:44 Outro

Recommended Reading

• World Organisation for Animal Health (WOAH). (2023). Ovine Pulmonary Adenocarcinoma (Jaagsiekte). In Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. WOAH PDF
• Cousens, C., et al. (2024). Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model. Genes, 15(8), 1019. https://doi.org/10.3390/genes15081019
• O’Conor, K. & Chase, C. C. L., (2020). 5-Minute Veterinary Consult: Ruminant, 2nd edn. Wiley-Blackwell. pp. 582-583. Constable, P. D., Hinchcliff, K. W., Done, S. H. & Grünberg, W., (2021). Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, 11th edn. Elsevier, pp. 977–979.

References

• Toma, C. et al. (2025). Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development. BMC Veterinary Research, 21, 29.
• Cousens, C., et al. (2024). Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model*.* Genes, 15(8), 1019. https://doi.org/10.3390/genes15081019.
• World Organisation for Animal Health (WOAH). (2023) Ovine Pulmonary Adenocarcinoma (Jaagsiekte). In: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. WOAH, Paris. Available at: https://www.woah.org/fileadmin/Home/fr/Health_standards/tahm/3.07.08_OPA.pdf
• O’Conor, K. & Chase, C. C. L., (2020). 5-Minute Veterinary Consult: Ruminant, 2nd edn. Wiley-Blackwell. pp. 582-583.
• Constable, P. D., Hinchcliff, K. W., Done, S. H. & Grünberg, W., (2021). Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, 11th edn. Elsevier, pp. 977–979.

Current Vet is an educational podcast intended for veterinary students, veterinary professionals, and individuals with an interest in veterinary medicine.

All content provided in this podcast and its associated materials is for educational and informational purposes only. It is not intended as, and must not be considered a substitute for, professional veterinary advice, diagnosis, or treatment.

Any clinical cases discussed in this podcast are fictional, and are designed to reflect typical or likely clinical scenarios for educational purposes. They do not represent specific real-life cases, clients, or animals.

While every effort is made to ensure accuracy and alignment with current evidence at the time of publication, veterinary medicine is a rapidly evolving field, and recommendations may change over time.

In this episode, Dr. Lottie talks about one of the most common endocrine disorders in small animal practice — Cushing’s disease

Find us on TikTok & Instagram: @veterinaryvista

Timeline:

• 00:00 Intro
• 00:31 Case
• 01:24 Aetiology & Pathogenesis
• 05:08 Clinical Signs
• 06:29 Diagnosis
• 13:21 Treatment
• 16:38 Recommendations
• 17:26 Key Points
• 18:54 Outro

Recommended Reading

• ACVIM Consensus Statement (2013)
• Nelson, R.W. and Couto, C.G. (2020): Small Animal Internal Medicine
• Feldman, E.C. and Nelson, R.W. (2014): Canine and Feline Endocrinology
• Veterinary Partner (VIN Foundation, open access)
• AAHA (2023): Selected Endocrinopathies Guidelines

References

• Behrend, E.N., Kooistra, H.S., Nelson, R., Reusch, C.E. and Scott-Moncrieff, J.C., 2013. Diagnosis of spontaneous canine hyperadrenocorticism: 2012 ACVIM consensus statement (small animal). Journal of Veterinary Internal Medicine, 27(6), pp.1292–1304. doi:10.1111/jvim.12192.
• Behrend, E.N., 2015. Canine hyperadrenocorticism. Clinical Techniques in Small Animal Practice, 30(1), pp.41–47. doi:10.1053/j.ctsap.2014.10.005.
• Feldman, E.C. and Nelson, R.W., 2014. Canine and Feline Endocrinology. 4th ed. St. Louis: Elsevier Saunders.
• Nelson, R.W. and Couto, C.G., 2020. Small Animal Internal Medicine. 6th ed. St. Louis: Elsevier.
• Ettinger, S.J. and Feldman, E.C., 2017. Textbook of Veterinary Internal Medicine. 8th ed. St. Louis: Elsevier Saunders.
• Veterinary Partner, VIN Foundation. 2025. Cushing’s Disease (Hyperadrenocorticism) in Dogs. [online] Available at: https://veterinarypartner.vin.com/ [Accessed 5 Sept. 2025].
• American Animal Hospital Association (AAHA), 2023. AAHA Selected Endocrinopathies of Dogs and Cats Guidelines – Canine Hypercortisolism (Cushing’s Syndrome). Lakewood, CO: AAHA. Available at: https://www.aaha.org/resources/2023-aaha-selected-endocrinopathies-of-dogs-and-cats-guidelines/canine-hypercortisolism-cushings-syndrome/ [Accessed 5 Sept. 2025].

Current Vet is an educational podcast intended for veterinary students, veterinary professionals, and individuals with an interest in veterinary medicine.

All content provided in this podcast and its associated materials is for educational and informational purposes only. It is not intended as, and must not be considered a substitute for, professional veterinary advice, diagnosis, or treatment.

Any clinical cases discussed in this podcast are fictional, and are designed to reflect typical or likely clinical scenarios for educational purposes. They do not represent specific real-life cases, clients, or animals.

While every effort is made to ensure accuracy and alignment with current evidence at the time of publication, veterinary medicine is a rapidly evolving field, and recommendations may change over time

Zoo and wildlife medicine is one of the most competitive and idealised areas of veterinary practice. From the outside, it’s dramatic, exciting, and very different from other veterinary careers. But what is the reality?

In this episode, Dr Lottie is joined by Dr Noi Psaroudaki, a zoo and wildlife veterinarian, to explore what zoo medicine actually involves and how the role differs from more traditional areas of veterinary practice.
Together, Dr Lottie and Dr Noi discuss not only the clinical aspects of the job, but also the ethical, emotional, and practical challenges that come with working in zoos and wildlife settings.
Dr Noi shares reflections from her own career, including cases that have shaped her approach to zoo med, the pressures that come with public scrutiny, and why zoo medicine is rarely what people expect when they first consider the field.
This episode is wonderful for veterinary students, new graduates, and vets who are curious about zoo or wildlife medicine, as well as anyone wanting to learn more about this non-traditional area of vet med!

Resources from the episode:

• EAZA Best Practice Guidelines: https://www.eaza.net/BPG/
• News stories covering the white tiger cub case: https://www.bornfree.org.uk/news/born-free-statement-white-tiger-cub/, https://www.theanimalreader.com/2023/03/19/news-greece-zoo-save-white-tiger-cub-garbage/, https://www.abc.net.au/news/2023-03-19/athens-zoo-fights-to-save-tiger-cub-found-in-garbage/102116700

Find Noi on Instagram: @noi_the_animal_doc
TikTok & Instagram: @veterinaryvista

Current Vet is an educational podcast intended for veterinary students, veterinary professionals, and individuals with an interest in veterinary medicine.

All content provided in this podcast and its associated materials is for educational and informational purposes only. It is not intended as, and must not be considered a substitute for, professional veterinary advice, diagnosis, or treatment.

While every effort is made to ensure accuracy and alignment with current evidence at the time of publication, veterinary medicine is a rapidly evolving field, and recommendations may change over time.