In this episode of Current Vet, Dr Lottie talks about Jaagsiekte, also known as Ovine Pulmonary Adenocarcinoma (OPA)

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Timeline:

• 00:00 Intro
• 00:56 Case
• 03:48 Aetiology & Pathogenesis
• 06:25 Clinical Signs
• 08:28 Diagnosis
• 12:34 Treatment
• 16:53 Current Research
• 18:09 Key Points
• 19:44 Outro

Recommended Reading

• World Organisation for Animal Health (WOAH). (2023). Ovine Pulmonary Adenocarcinoma (Jaagsiekte). In Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. WOAH PDF
• Cousens, C., et al. (2024). Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model. Genes, 15(8), 1019. https://doi.org/10.3390/genes15081019
• O’Conor, K. & Chase, C. C. L., (2020). 5-Minute Veterinary Consult: Ruminant, 2nd edn. Wiley-Blackwell. pp. 582-583. Constable, P. D., Hinchcliff, K. W., Done, S. H. & Grünberg, W., (2021). Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, 11th edn. Elsevier, pp. 977–979.

References

• Toma, C. et al. (2025). Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development. BMC Veterinary Research, 21, 29.
• Cousens, C., et al. (2024). Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model*.* Genes, 15(8), 1019. https://doi.org/10.3390/genes15081019.
• World Organisation for Animal Health (WOAH). (2023) Ovine Pulmonary Adenocarcinoma (Jaagsiekte). In: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. WOAH, Paris. Available at: https://www.woah.org/fileadmin/Home/fr/Health_standards/tahm/3.07.08_OPA.pdf
• O’Conor, K. & Chase, C. C. L., (2020). 5-Minute Veterinary Consult: Ruminant, 2nd edn. Wiley-Blackwell. pp. 582-583.
• Constable, P. D., Hinchcliff, K. W., Done, S. H. & Grünberg, W., (2021). Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, 11th edn. Elsevier, pp. 977–979.

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