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In Part 1, Anna Butterworth introduces the first three of five menopause archetypes from her Future of Menopause 2035 report – the Peri Prepper, the Seeker and the High Performer – exploring who each woman is, what she needs and where the current system falls short.

Key Topics:

• The Future of Menopause 2035 report and why archetypes matter

• 48 symptoms of menopause and the problem with generic solutions

• The Peri Prepper: preparing for perimenopause in your mid-thirties

• GPs dismissing younger women who want to prepare early

• Millennials ageing into menopause with cycle-tracking literacy

• The AI slop era and the challenge of validating health information

• The Seeker: holistic wellness meets evidence-based rigour

• The gap between data-led tools and spiritually-oriented tools

• The High Performer: brain fog, boardrooms and the £150bn cost

• The link between menopause-related brain fog and long-term dementia risk

• Menopause benefits as the next frontier in talent retention

• The wisdom workforce: why younger women watch how companies treat older staff

References & Resources Mentioned:

• The Future of Menopause 2035 – Ultraviolet Agency report - https://www.ultravioletagency.com

• Bloomberg statistic: £150 billion global economic cost of menopause-related symptoms

Guest Links

• Ultraviolet Agency – https://www.ultravioletagency.com

• Anna Butterworth LinkedIn – https://www.linkedin.com/in/annabutterworth

Insta/TikTok: @BiohackingEve
Website: www.BiohackingEve.com

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Episode description

In Part 2, Yulia Mintchin gets practical — covering what women should actually do at every stage, the FemGene patient journey, her own health transformation on HRT at 31, and a surprising conversation about art, creativity and feminine power as the next frontier in women’s health

Key topics discussed

• Top three interventions for women aged 30–45
• When to start genetic testing, with Yulia’s view being post-puberty
• Cyclical nutrition: why carbs in the luteal phase support progesterone
• Why cryotherapy and cold exposure can backfire depending on genetic stress response
• Medical curriculum gaps: why perimenopause does not belong in sick care
• The gold standard perimenopause visit in 2030
• Will Be’s pharmacogenomic platform vision
• Insurance models and the economics of preventative medicine
• FemGene patient journey: telemedicine, test kits, Dr Vanessa consultation
• Can oestrogen receptors reactivate post-menopause? Emerging research
• Optimal hormones as a foundational baseline, not a longevity bonus
• Peptides: only stack after hormonal foundations are in place
• Yulia’s personal story: health crisis at 31, HRT and the endometriosis link
• Keto, sourdough and changing her mind on carbs
• The digital twin: which data streams matter and which are just noise
• Curveball: the billboard question — rewriting behaviour patterns through art
• Remember Who You Are — Yulia’s musical
• Joseph Campbell, the hero’s journey and stories as healing
• Spiral dynamics and collective consciousness
• A Russian utopian book by a female author written during the USSR period
• Peptides for mitochondria as a sub-$1,000 purchase recommendation
• Piano as an introvert’s creative practice
• Biohacking Eve episode on EMS (Episode 3)

Timestamps

00:00 Why Part 2 is the action plan
01:00 Top interventions before HRT
02:20 Keto, carbs and cyclical eating
07:00 What a gold standard perimenopause visit should look like
09:30 Insurance, self-pay and democratising access
13:20 The research questions FemGene wants to answer
18:10 Why Yulia started HRT at 31
23:10 “It’s not too early” for hormone optimisation
25:00 Female digital twins and meaningful data
27:10 Why optimal hormones are a baseline, not a luxury
30:40 Why fasting and cryo are not for everyone
33:35 One change healthcare professionals can make now
35:50 Art, feminine energy and women’s health
44:30 The spiritual experiences behind Yulia’s mission
49:45 Peptides, piano and personal rituals
53:40 What comes next for Will Be and FemGene

References and resources mentioned

• FemGene hormone genomic test — via Will Be: https://www.mywillbe.co.uk/
• Joseph Campbell — The Hero with a Thousand Faces
• Spiral dynamics — developmental model of collective consciousness
• Biohacking Eve episode on EMS / strength training, referenced as approximately Episode 3
• A Russian utopian book by a female author, written during the USSR period
• Remember Who You Are — musical by Yulia Mintchin
• Health Optimisation Summit, London
• Dr Vanessa — chief scientist at Will Be

Guest social links

• &n

Insta/TikTok: @BiohackingEve
Website: www.BiohackingEve.com

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Episode description

Yulia Mintchin, Forbes 30 Under 30 entrepreneur and creator of FemGene, reveals why perimenopause is an epigenetic reprogramming event — not just a hormone dip — and how genetic testing can predict your symptoms and HRT response before a single prescription is written

Key topics discussed

• Perimenopause as a communication breakdown between genes and hormones
• Why women were excluded from medical research and what that means today
• Hormone genomics and hormone genetics — a new medical category
• The three hormonal archetypes: Sensitive, Silent and Resilient
• The COMT gene variant and oestrogen clearance, affecting around 20% of the population
• Why HRT fails for 40% of women — and how FemGene aims to fix that
• Hormone metabolites vs hormone levels: the missing safety step
• Bioidentical vs synthetic oestrogen — the cherry Haribo analogy
• Endometriosis case study: progesterone and halted progression
• Oncology’s shifting stance on HRT and oestrogen during cancer treatment
• The WHI study and tamoxifen: historical context

Timestamps

00:00 Why perimenopause may be about genetic response, not just hormone decline
01:00 Meet Yulia Mintchin and the FemGene thesis
03:10 Why perimenopause is medicine’s biggest blind spot
05:05 Hormone genomics and hormone genetics explained
14:15 The three hormonal archetypes: Sensitive, Silent and Resilient
23:05 Why doubling HRT doses can backfire
24:10 COMT, oestrogen clearance and personalisation
31:40 When women should start testing
33:20 Endometriosis case study: progesterone and progression
37:20 How archetypes change HRT decisions
41:05 What the FemGene process looks like
45:00 Bioidentical vs synthetic oestrogen
51:20 Red flags that HRT is being managed poorly
56:05 Oncology, HRT and shifting views on oestrogen
58:10 Outro and disclaimer

References and resources mentioned

• FemGene hormone genomic test — via Will Be: https://www.mywillbe.co.uk/
  
  
• The WHI (Women’s Health Initiative) study — landmark trial that shaped HRT policy
• Biohacking Eve episode with Jennifer Garrison, referenced as approximately Episode 1, on hormonal changes affecting 80% of body systems
• COMT gene and oestrogen metabolism — widely studied SNP; Yulia references the slow COMT variant
• Tamoxifen and breast cancer treatment — historical context discussed

Guest social links

• Instagram: https://www.instagram.com/yulia.mintchin/
• LinkedIn: https://www.linkedin.com/in/yuliamintchin/
• Will Be website: https://www.mywillbe.co.uk/

Insta/TikTok: @BiohackingEve
Website: www.BiohackingEve.com