American artist Joseph Hannigan and his alluring sister, Sophie, have arrived in enchanting nineteenth-century Venice with a single-minded goal. The twins, who have fled scandal in New York, are determined to break into Venice's expatriate set and find a wealthy patron to support Joseph's work.
But the enigmatic Hannigans are not the only ones with a secret agenda. Joseph's talent soon attracts the attention of the magnificent Odilé Leon, a celebrated courtesan and muse who has inspired many artists to greatness. But her inspiration comes with a devastatingly steep price.
As Joseph falls under the courtesan's spell, Sophie joins forces with Nicholas Dane, the one man who knows Odilé's dark secret, and her sworn enemy. When the seductive muse offers Joseph the path to eternal fame, the twins must decide who to believe - and just how much they are willing to sacrifice for fame.