When an enigmatic town doctor saves the life of Anisa Worthington’s dying son, she abandons Christianity in favor of devotion to the cult of Santa Muerte - or Saint Death. Some believe the mysterious skeleton saint will protect their loved ones, help in matters of the heart, and provide abundant happiness, health, wealth, and justice. But others, including the Catholic Church, call the cult blasphemous, evil, and satanic.

Anisa introduces Santa Muerte to her friend, Helen Randon, and soon one of Helen’s enemies is brutally murdered. Residents of Montague, a peaceful little town in Prince Edward Island, begin plotting to rid the Bible belt of apostates. Anisa suspects Helen is perverting the good tenets of Saint Death. Before she can act, a terrible nightmare propels her to the Dominican Republic in search of Franklin, her long-lost and unstable brother, who mysteriously disappeared without a trace 20 years ago. To her horror, Anisa learns Franklin is worshiping Saint Death with evil intentions.

As a fanatical and hell-bent lynch mob tightens the noose, mysterious murders begin occurring all around Anisa. Unsure who’s an enemy and who’s an ally, she’s thrust into a violent battle to save her life, as well as the lives of her friends and brother.