An unassuming woman wanders around the landscape of hell accompanied by a dammed priest and a '60s-style teenage demon activist. The trio is sometimes helped and sometimes hindered by a god-like being with dysfunctional split personalities. The series contains many plots and subplots. There is an overall plot that runs throughout the series that involves the nature of Hell being altered by the unintentional efforts of the trio. Equally, there are individual plots for each episode. Several other plots exist that cover intrigues between Heaven, Hell, and the Earth; God, the Devil, and Man.

The audiobook has been produced in the style of a radio show with actors and audio effects. It is part of a 21-episode series. This audiobook includes:

Episode 1- A Narrow Escape

Episode 1 finds Laura sowed away on top of a school bus filled with little angels on a field trip to Hell. She tells the border guard the story of her journeys through Hell in hopes of gaining political asylum in Heaven. Thus begins the remarkable and comical story of "The Hitchhiker’s Guide to Heaven, Hell, and Everything Else in Between".

Episode 2 - Anger Management

Laura describes how she wound up in the wrath level where she took on Wrath as an anger management student. Wrath uses his new skills to help him manage his anger in his day-to-day life. Finally, he has a heart to heart with his conscience and thinks he uncovers the real problem.

Episode 3 - How It Began

We flashback to the customs interview where Laura finds the real question is how did she get to Hell in the first place. Laura begins to explain, and we flashback to San Francisco International airport. Laura is put on a flight along with three terrorists. On the plane, she wrestles with them and their bomb goes off blowing up the plane and sending them all to Hell. She finds herself in a waiting room in hell. Through a series of misunderstandings, she winds up in the back alleys of Hell.