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Your Brain On

Your Brain On

Von: Drs. Ayesha and Dean Sherzai
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 A podcast about the neuroscience of everything. From neurologists, researchers, and public health advocates Drs. Ayesha and Dean Sherzai, explore every aspect of our world through a neuroscientific lens, with science-based stories, interviews, anecdotes, and brain health facts. Equip yourself with neurologically sound answers to life's everyday health questions and learn the essentials of brain health and optimization, one topic at a time.2024 Hygiene & gesundes Leben Wissenschaft
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  • Your Brain On... Menopause Hormone Therapy

    Your Brain On... Menopause Hormone Therapy
    May 13 2026
    Menopause hormone therapy and your brain: what the evidence says vs. what the algorithm is selling you. Two-thirds of Alzheimer's patients are women. That statistic has fueled a social media narrative that hormone therapy can prevent dementia, but the current evidence doesn't support that claim. In this episode, Drs. Ayesha and Dean Sherzai sit down with OBGYN Dr. Jen Gunter and neuroscientist Dr. Sarah McKay to separate the science from the soundbites. Your Brain On... Menopause Hormone Therapy [Season 7, Episode 1] Get our FREE NEURO Plan Brain Health Playbook: https://thebraindocs.com/playbook In this episode: Why menopause hormone therapy is the gold standard for hot flashes and night sweats but not a proven tool for dementia preventionThe Women's Health Initiative: what it actually found, how the press conference distorted the findings, and what we've learned sinceWhy "bioidentical hormones" is a marketing term, not a medical one, and what that means for the products being sold to youHow the hypothalamus drives vasomotor symptoms and why sleep disruption may explain much of the cognitive fog women experience at midlifeThe high placebo response rate with hormone therapy and why dose escalation can mask a missed diagnosisWhy the simplistic narrative of "women get more Alzheimer's, so it must be menopause, so give hormones" falls apart under scrutinyHow over-testing, unregulated lab panels, and wearable hormone data can create more anxiety than answersThe case for perimenopause as a life stage, not a disease, and why medicalizing normal midlife stress upholds harmful structuresWhat the aging brain actually gains: vocabulary, emotional processing, wisdom, complex problem-solving, and the capacity to hold nuance7 evidence-based actions you can take this week for your brain health, no prescription requiredWhy the FDA's removal of the black box warning on hormone therapy was released without context and what happened next on social mediaThe new neurokinin receptor antagonists and why they could change how we study the relationship between hot flashes and brain health 00:00 Intro 01:09 Why the menopause hormone therapy conversation matters 07:10 Dr. Jen Gunter: the dangerous dichotomy around MHT 10:20 The Women's Health Initiative, revisited 16:25 Who is menopause hormone therapy actually for? 18:20 The placebo response nobody talks about 22:33 When does perimenopause actually start? 26:00 Does MHT actually prevent dementia? 29:11 "Bioidentical" is not a medical term 36:27 The problem with unregulated hormone testing 41:08 How to advocate for yourself at the doctor 44:36 New drugs that could change menopause research 47:17 The pTau217 study and what it means for women on MHT 52:20 Dr. Sarah McKay: what happens in your brain during menopause 59:34 The oversimplified estrogen-Alzheimer's story 1:04:13 When social media primes your symptoms 1:11:18 What the aging brain actually gains 1:21:35 Grandmothers rule the world! 1:25:43 What MHT is actually good for 1:26:28 7 things to do for your brain Dr. Jen Gunter is an OBGYN, pain medicine physician, New York Times columnist, and bestselling author of The Menopause Manifesto, The Vagina Bible, and Blood. She writes The Vajenda on Substack and is one of the most prominent voices challenging misinformation in women's health. Dr. Sarah McKay is a neuroscientist, science communicator, and author of The Women's Brain Book. She is the founder of The Neuroscience Academy and Think Brain training programs. References: North American Menopause Society 2022 Hormone Therapy Guidelines: menopause.org Australasian Menopause Society: menopause.org.au The Vajenda (Substack): jenssubstack.com Get our FREE NEURO Plan Brain Health Playbook: https://thebraindocs.com/playbook Hosted by Drs. Ayesha & Dean Sherzai. Subscribe to The Synapse (free weekly newsletter): thebraindocs.com/newsletter Follow @TheBrainDocs on Instagram
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    1 Std. und 29 Min.
  • Your Brain On... Vascular Dementia

    Your Brain On... Vascular Dementia
    Feb 4 2026
    Most people think dementia starts with memory loss. But for millions, it actually begins decades earlier: in the blood vessels. Long before someone forgets a name or misses an appointment, the brain is being quietly damaged by high blood pressure, cholesterol imbalance, poor sleep, inflammation, and chronic stress, day after day, year after year. This kind of damage doesn't look dramatic. There's no big stroke, no clear warning sign. It happens slowly and silently, which is why it's so often missed until it's too late. But here's the good news: vascular dementia is one of the most preventable and manageable forms of cognitive decline. When caught early, lifestyle changes and medical interventions can help slow the onset and manage the effects. In this episode, we explore: What vascular dementia and vascular cognitive impairment are, and how they differ from Alzheimer's diseaseWhy most dementia cases involve both vascular damage and neurodegenerative pathology (mixed dementia)How blood vessel damage begins in childhood and accumulates silently for decadesThe role of high blood pressure, cholesterol, diabetes, sleep disorders, and chronic stress in damaging brain vasculatureWhy slowed thinking, movement, and processing speed are hallmark signs of vascular cognitive declineThe critical importance of the endothelium: the thin lining of blood vessels that controls brain healthHow lifestyle factors like nutrition, exercise, sleep, and stress management protect and repair vascular healthWhy managing blood pressure early is one of the most powerful interventions for long-term brain health (and why everyone should have a blood pressure monitor at home!)How vascular damage can be slowed, even in midlifePractical steps for prevention across the lifespan, from childhood through older adulthood Our guest for this episode is DR. COLUMBUS BATISTE, a board-certified interventional cardiologist, an incredible science communicator, and author of 'Selfish: A Cardiologist's Guide to Healing a Broken Heart'. Dr. Batiste brings deep expertise on how cardiovascular health shapes brain health, and why protecting the endothelium (the inner lining of blood vessels) is foundational to longevity. His work emphasizes that all roads to longevity are paved by the heart, and what's good for the heart is good for the brain! 'Your Brain On…' is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai. SUPPORTED BY: NEURO World, a science-based brain health community designed to help you protect your brain long before problems begin. Learn more at https://neuro.world/ 'Your Brain On… Vascular Dementia' • SEASON 6 • EPISODE 8 ——— LINKS Dr. Columbus Batiste: https://drbatiste.com/ Instagram: @HeartHealthyDoc Facebook: https://www.facebook.com/drbatiste ——— FOLLOW US Join NEURO World: https://neuro.world/ Instagram: https://www.instagram.com/thebraindocs YouTube: https://www.youtube.com/thebraindocs ——— REFERENCES Core Definitions & Diagnostic Framework • Diagnostic and Statistical Manual of Mental Disorders (5th ed.) - American Psychiatric Publishing • Vascular contributions to cognitive impairment and dementia - https://doi.org/10.1161/STR.0b013e3182299496 • Classifying neurocognitive disorders: The DSM-5 approach - https://doi.org/10.1038/nrneurol.2014.181 Epidemiology & Public Health Burden • Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease - https://doi.org/10.1007/s00401-016-1571-z • Vascular dementia - https://doi.org/10.1016/S0140-6736(15)00463-8 • Risk reduction of cognitive decline and dementia: WHO guidelines - WHO Press Small Vessel Disease & Subcortical Vascular Dementia • Small vessel disease: Mechanisms and clinical implications - https://doi.org/10.1016/S1474-4422(19)30079-1 • Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges - https://doi.org/10.1016/S1474-4422(10)70104-6 • The clinical importance of white matter hyperintensities on brain magnetic resonance imaging - https://doi.org/10.1136/bmj.c3666 Mixed Dementia & Alzheimer–Vascular Overlap • Mixed brain pathologies account for most dementia cases in community-dwelling older persons - https://doi.org/10.1212/01.wnl.0000271090.28148.24 • Early role of vascular dysregulation on late-onset Alzheimer's disease - https://doi.org/10.1016/j.neurobiolaging.2016.04.009 • The pathobiology of vascular dementia - https://doi.org/10.1016/j.neuron.2013.10.008 Cerebral Amyloid Angiopathy (CAA) • Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways - https://doi.org/10.1038/s41582-019-0281-2 • Emerging concepts in sporadic cerebral amyloid angiopathy - https://doi.org/10.1093/brain/awx047 Genetics, Inflammation, and Repair • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A - https://doi.org/...
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    1 Std. und 22 Min.
  • Your Brain On... Cold Plunges

    Your Brain On... Cold Plunges
    Jan 21 2026
    Cold plunges are everywhere, and the way people talk about them, you'd think they're a miracle cure for your brain, body, and soul. But in an age of algorithm-fueled evangelism, when a ritual becomes this ubiquitous and loud, we have to ask: how much of the buzz is backed by science… and how much is just marketing? In this episode, we explore the neuroscience of cold exposure: what's real, what's overstated, and why this "discomfort" has become a billion-dollar industry. We discuss: Why cold plunges went viral, and how wellness movements often devolve into identity-driven culturesThe difference between cold exposure itself and the monetized "cold plunge movement"What constitutes a "cult" (and how pseudoscience forms around partial truths)The real physiological cold shock responseWhy the mental "high" after a plunge doesn't automatically equal long-term brain benefitThe cardiovascular risks that rarely get discussed, especially for people with underlying heart diseaseWhat the research suggests about soreness, pain reduction, and muscle growth (including why cold immersion can blunt hypertrophy)The real story behind brown fatWho should avoid cold plunges altogether (asthma, arrhythmias, coronary disease, vascular conditions) Joining us for this conversation is investigative journalist and bestselling author Scott Carney (What Doesn't Kill Us, The Wedge), who has spent years inside the cold exposure world, first as a skeptic, then as a believer, and eventually as a critic of the culture that formed around it. His work reveals what happens when discomfort becomes identity, and when unfounded "social media science" outruns real science. Your Brain On... is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: neuroworldretreat.com Your Brain On... Cold Plunges • SEASON 6 • EPISODE 7 REFERENCES Cold Water Immersion, Muscle Adaptation, and Recovery Roberts, L. A., Raastad, T., Markworth, J. F., Figueiredo, V. C., Egner, I. M., Shield, A., Cameron-Smith, D., Coombes, J. S., & Peake, J. M. (2015). Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training. Journal of Physiology, 593(18), 4285–4301. https://doi.org/10.1113/JP270570 Bleakley, C. M., McDonough, S. M., & MacAuley, D. C. (2004). The use of ice in the treatment of acute soft-tissue injury: A systematic review of randomized controlled trials. American Journal of Sports Medicine, 32(1), 251–261. https://doi.org/10.1177/0363546503260757 Leeder, J., Gissane, C., van Someren, K., Gregson, W., & Howatson, G. (2012). Cold water immersion and recovery from strenuous exercise: A meta-analysis. British Journal of Sports Medicine, 46(4), 233–240. https://doi.org/10.1136/bjsports-2011-090061 White, G. E., & Wells, G. D. (2013). Cold-water immersion and other forms of cryotherapy: Physiological changes potentially affecting recovery from high-intensity exercise. Sports Medicine, 43(8), 695–706. https://doi.org/10.1007/s40279-013-0055-8 Kellmann, M., Bertollo, M., Bosquet, L., Brink, M., Coutts, A. J., Duffield, R., Erlacher, D., Halson, S. L., Hecksteden, A., Heidari, J., Kölling, S., Meyer, T., Mujika, I., Robazza, C., Skorski, S., Venter, R., & Beckmann, J. (2018). Recovery and performance in sport: Consensus statement. International Journal of Sports Physiology and Performance, 13(2), 240–245. https://doi.org/10.1123/ijspp.2017-0759 Inflammation, Pain, and Perceived Recovery Hohenauer, E., Taeymans, J., Baeyens, J. P., Clarys, P., & Clijsen, R. (2015). The effect of post-exercise cryotherapy on recovery characteristics: A systematic review and meta-analysis. PLoS ONE, 10(9), e0139028. https://doi.org/10.1371/journal.pone.0139028 Costello, J. T., Culligan, K., Selfe, J., & Donnelly, A. E. (2012). Muscle, skin and core temperature after –110°C cold air and 8°C water treatment. PLoS ONE, 7(11), e48190. https://doi.org/10.1371/journal.pone.0048190 Brown Adipose Tissue (BAT) – Human Imaging & Metabolism van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. (2009). Cold-activated brown adipose tissue in healthy men. New England Journal of Medicine, 360(15), 1500–1508. https://doi.org/10.1056/NEJMoa0808718 Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N. J., Enerbäck, S., & Nuutila, P. (2009). Functional brown adipose tissue in healthy adults. New England Journal of Medicine, 360(15), 1518–1525. https://doi.org/10.1056/NEJMoa0808949 Betz, M. J., & Enerbäck, S. (2015). Human brown adipose tissue: What we have learned so far. Diabetes, 64(7), 2352–2360. https://doi.org/10.2337/db15-0146 Autonomic Nervous System, HRV, and Cold Exposure Mourot...
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    47 Min.
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