How do you know if your patient will benefit from liver-directed therapy for colorectal cancer? Join experts Drs Benjamin Schlechter and Ammar Sarwar as they discuss.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/988973). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Colon Cancer https://emedicine.medscape.com/article/277496-overview

Locoregional Liver-directed Therapies to Treat Unresectable Colorectal Liver Metastases: A Review https://pubmed.ncbi.nlm.nih.gov/35180338/

History and Evolution of Yttrium-90 Radioembolization for Hepatocellular Carcinoma https://pubmed.ncbi.nlm.nih.gov/30621040/

SIRFLOX: Randomized Phase III Trial Comparing First-line mFOLFOX6 (Plus or Minus Bevacizumab) Versus mFOLFOX6 (Plus or Minus Bevacizumab) Plus Selective Internal Radiation Therapy in Patients With Metastatic Colorectal Cancer https://pubmed.ncbi.nlm.nih.gov/26903575/

First-line Selective Internal Radiotherapy Plus Chemotherapy Versus Chemotherapy Alone in Patients With Liver Metastases From Colorectal Cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): A Combined Analysis of Three Multicentre, Randomised, Phase 3 Trials https://pubmed.ncbi.nlm.nih.gov/28781171/

Radioembolization With Chemotherapy for Colorectal Liver Metastases: A Randomized, Open-label, International, Multicenter, Phase III Trial https://pubmed.ncbi.nlm.nih.gov/34541864/

FOLFOX Regimen https://www.cancer.gov/publications/dictionaries/cancer-terms/def/folfox-regimen

FOLFIRI (Folinic Acid, Fluorouracil, and Irinotecan) Increases not Efficacy but Toxicity Compared With Single-agent Irinotecan as a Second-line Treatment in Metastatic Colorectal Cancer Patients: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/35069808/

Hepatic Chemoembolization https://www.ncbi.nlm.nih.gov/books/NBK507822/

Post-embolization Syndrome as an Early Predictor of Overall Survival After Transarterial Chemoembolization for Hepatocellular Carcinoma https://pubmed.ncbi.nlm.nih.gov/26374137/

When Should You Consider Immunotherapy in Colorectal Cancer https://www.medscape.com/viewarticle/986437

FOLFOXIRI Reintroduction in Metastatic Colorectal Cancer https://pubmed.ncbi.nlm.nih.gov/32164907/

A Review of Applying Transarterial Chemoembolization (TACE) Method for Management of Hepatocellular Carcinoma https://pubmed.ncbi.nlm.nih.gov/34934646/

Lipiodol Transarterial Chemoembolization for Hepatocellular Carcinoma: A Systematic Review of Efficacy and Safety Data https://pubmed.ncbi.nlm.nih.gov/26765068/