Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

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Oct 10, 2025 This Week in Cardiology Podcast

https://www.medscape.com/viewarticle/1002990

• ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370

II FFR Without the Wire – Angiography-Derived FFR to Guide PCI

• ALL-RISE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600949
• FAST III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601841
• FAVOR III Trial 10.1016/S0140-6736(24)02175-5 External Link
• FAME 2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1205361
  
• Venk Murthy on X https://x.com/venkmurthy/status/2074849421452329456?s=20

III More Bad News for Ticagrelor

Jul 11, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002704

• Prasugel, Ticagrelor, or Clopidogrel After PCI https://jamanetwork.com/journals/jamacardiology/fullarticle/2849614

IV The Polypill in Heart Failure

• POLY-HF trial https://www.nature.com/articles/s41591-026-04504-5

V Oxygen Targets After Cardiac Arrest

• LOGICAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513814
• ICU-ROX Trial https://link.springer.com/article/10.1007/s00134-020-06196-y
• Secondary Analysis of the PILOT Trial https://journal.chestnet.org/article/S0012-3692(25)00553-7/fulltext
• Oxygen Targets in Comatose Survivors of Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa2208686

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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

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Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

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• PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137

II Statins and Frailty

Statin Initiation Tied to Lower Frailty Risk in Older Adults https://www.medscape.com/viewarticle/statin-initiation-tied-lower-frailty-risk-older-adults-2026a1000lec

• Statins and Survival Free of Incident Frailty https://doi.org/10.1093/eurheartj/ehag451

III LA Posterior Wall Isolation Fails Again

• CORNERSTONE Trial https://doi.org/10.1093/eurheartj/ehag486
• CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186

IV Does the Display of Test Results Improve Clinical Decisions?

• Interval Likelihood Ratios for Clinical Decsion-Making https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500249
• Making Sense of Health Statistics https://journals.sagepub.com/doi/full/10.1111/j.1539-6053.2008.00033.x

V AI and the ECG and Saving Doctors

• Case Report — AI-Enhanced Diagnostics https://www.nature.com/articles/s41591-026-04454-y
• The New York Times article https://www.nytimes.com/2026/06/22/health/artificial-intelligence-heart-damage.html

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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Listener feedback, more long-term data on the TAVR/SAVR question, population prevalence of valvular heart disease in the US, and a CMS proposal to expand TAVR coverage are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Listener Feedback

• ICD Trends and Outcomes: 15-Year Analysis https://doi.org/10.1093/europace/euag110
• MADIT-RIT https://www.nejm.org/doi/full/10.1056/NEJMoa1211107

II More Long Term Data on TAVR vs SAVR

• PARTNER 2 Trial https://www.jacc.org/doi/10.1016/j.jacc.2026.03.169
• 10-Year Outcomes of SAPIEN 3 TAVR or SAVR in Intermediate-Risk Patients https://doi.org/10.1016/j.jacc.2026.03.170
• TAVR at a Decade: Editorial https://doi.org/10.1016/j.jacc.2026.04.042
• EVOLUT Trial https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063
• Updated 5-year Outcomes of TAVR vs SAVR in AS https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092
• NOTION Trial https://doi.org/10.1093/eurheartj/ehae043
• PARTNER 3 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509766
• NOTION 2 Trial https://academic.oup.com/eurheartj/article/45/37/3804/7673297
• TAVR vs SAVR Editorial : https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehag407/8708044

III The PREVUE-VALVE Study

• PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137

IV CMS has Proposed New Coverage for TAVR

• CMS Proposal Document https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=Y&ncaId=321

You may also like:

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net