Dr. Majid Fotuhi is a neuroscientist and clinician who has built his career around advancing brain health, with work spanning research, teaching, and patient care. He earned his PhD in neuroscience from Johns Hopkins University in 1992 and his medical degree from Harvard Medical School in 1997, and he now teaches at Johns Hopkins, George Washington University, and Harvard Medical School.

Known for his Brain Fitness Program, which blends a detailed baseline assessment with weekly training sessions, he focuses on lifestyle and cognitive strategies to improve memory, focus, and long-term brain resilience.

In our conversation, he emphasized that many symptoms women face during menopause are temporary, saying that brain fog and memory lapses “are transient and usually subside after hormone fluctuations settle,” and he encouraged a lifestyle of exercise, diet, sleep, mindset and brain training aiming to reach one’s nineties “and be sharp.”

Dave Asprey is a Health Science and Biotech Entrepreneur, 4x New York Times Bestselling Author and is often referred to as “The Father of Biohacking.” As the CEO and Founder of Upgrade Labs, the world’s first Human Upgrade™ center focused on longevity, weight loss, recovery, human performance and cognitive function, his work has led to the development of science-backed methods and products that enhance mental and physical well-being. Dave is also the host of The Human Upgrade podcast, where he shares his insights and expertise with a global audience.Coining the term “biohacking,” Dave’s personal health transformation—overcoming brain fog, pre-diabetes, and premature aging—led him to create The Bulletproof Diet and launch Upgrade Labs. Dave is dedicated to helping individuals take control of their biology, using data-driven insights and technology to enhance mental and physical performance.

In this episode, Dave and I discuss how women are the OG biohackers and how to make significant changes to your longevity and sleep during midlife.

Shawna Robins, founder and CEO of Third Spark interviews Taylor Berggren, lead microbiome expert at Pendulum Therapeutics. They discuss while your gut microbiome changes during midlife, how it affects your sleep, and which probiotics are best for improving GLP-1s to cut cravings and lose weight naturally.