When Vance Crowe learned he needed half his thyroid removed, it sparked a deep question: what does it mean when your body's clock gets disrupted? In this candid and wide-ranging conversation, Vance brings on geneticist and light researcher Kate Crosby — someone he talks to almost daily — to explore the science behind the body's hidden timekeepers.
They dig into how the thyroid regulates hormones and why losing it might put you on "synthetic time," why vitamin D and magnesium are so tightly linked, how intense exercise can unlock forgotten memories, and the surprising ways your ancestral latitude shapes everything from your seasonal diet to your fertility. The conversation takes unexpected turns into sunlight exposure, skin hardening, the Protestant vs. Catholic divide mapped onto geography, and whether modern life has knocked our biological clocks permanently off course.
This is the kind of conversation Vance wants his daughters to hear — honest, curious, and willing to follow ideas wherever they lead.
Guest: Kate Crosby is a geneticist and researcher specializing in light biology and light recipes for plant growth and human health.

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Vance is back in the saddle, kicking off the new run of the show with Shay Falk for a wide-ranging, live conversation that starts in ag-tech and rides straight into faith, leadership, and how AI is reshaping both business and culture.


Shay unpacks the origin story of Farm Profit Manager — how he, his brother Mac, and cousin Sam transformed a 30-year consulting tool from AgView Solutions into free software, why they bet on connection and advisory work rather than SaaS fees, and how rapid feedback, GitHub discipline, and even mermaid diagrams are helping them ship fast. Vance and Shay dig into the rise of vibe coding, the coming disruption to pricey ag apps, and the practical lessons of building durable AI systems.


From there the conversation pivots into theology and community: the resurgence of churchgoing, the differences between Catholic symbolism and Protestant literalism, how history and geography shaped American denominations, and what leadership and humility actually look like — whether in combat or on a church session. They wrestle with AI's role in faith (should LLMs write homilies?), Dunbar's number, and why shared language and first principles matter just as much in congregations as in companies.
It's a candid, spirited conversation about tools, tradition, and purpose — and why now is the moment to build and to reconnect.

Vance Crowe returns to the podcast after several months away with a vision for how AI agents are about to reshape commerce — and an explanation of where he's been. He argues the era of Google search is ending: websites built to communicate with AI agents, not human readers, will win the next decade. Using grass-fed beef as an extended example, Crowe walks through how AI agents will handle product discovery, payment, logistics, and recurring delivery on behalf of consumers, and what that shift means for small producers who have long struggled to reach customers directly. He also offers a caution drawn from his own experience: building too much too fast with AI creates brittle systems that break in unexpected ways.


In the second half, Crowe explains his absence. A January case of shingles was followed by the discovery that a long-standing lump on his throat was cancer — low likelihood of malignancy and highly treatable, but enough to reorder his priorities. He describes using AI to make Articulate Ventures more resilient: bringing on Brian King as a new host for online Legacy Interviews (legacyinterviews.com), building a signup system for his Interest-Based Communications classes (articulate.ventures/ibc), and scaling back his own interview load to spend more time with family. He closes by reflecting on why facing a potentially serious diagnosis left him calm rather than anxious.

Upcoming IBC classes in St. Louis: June 1–3 and July 6–8, 2026. Limited to 12 participants per class. Sign up at articulate.ventures/ibc.