Angel investing in medical technology can be tough. The science is complex, the timelines are long, and the risks are hard to judge without the right expertise in the room. At the New York Angels, that has changed. In this New York Angels edition of The Angel Nest, we meet NYA members and medical experts Vijay Aggarwal, PhD and John Younger, and learn how they evaluate life science opportunities. Joining them is Greg Fischer, founder and CEO of AIM Medical Robotics, one of the standout companies the New York Angels chose to fund. AIM is bringing a compact surgical robot to neurosurgery that works inside an MRI scanner in real time. The core problem it solves has haunted neurosurgeons for decades: the brain moves during surgery. Targets the size of a grain of rice can shift millimeters to centimeters mid-procedure, making preoperative maps unreliable exactly when precision matters most. AIM's robot continuously updates its guidance using live MRI imaging for conditions including Parkinson's disease, epilepsy, and brain cancer. Greg, Vijay, and John discuss what it takes to evaluate a medtech company before there is revenue, why AIM's FDA path is unusually clean, how existing reimbursement codes remove one of the biggest commercialization headaches in medical devices, and what the next wave of medtech investment looks like. Learn more about AIM Medical Robotics and find out who the New York Angels are partnering with at newyorkangels.com. Reach us with comments and listen to past episodes at theangelnest.com.

When Pascal de Mul was part of a young Spotify team revolutionizing music distribution, he unintentionally killed something he loved: the live bootleg. Now he is bringing it back, legally and in studio quality. Today on The Angel Nest, we meet Pascal de Mul, founder of Setmixer, the UK-based music technology company that permanently installs recording equipment directly into venue mixing desks, capturing every live performance in full multitrack studio quality and delivering it to fans almost instantly. Artists keep 70% of every sale and remain in full control of their recordings. Joining Pascal is Daryl Clarke, incoming chairman and serial entrepreneur with a history of building and profitably exiting businesses. Daryl discovered Setmixer the way great opportunities often arrive, on a random double date, and has not stopped thinking about it since. He is joining to leverage his business relationships and open doors to major music and entertainment companies and artist management firms. Together they discuss how Setmixer is already operating across 75 UK venues, a weekly showcase newsletter that connects grassroots artists directly to major labels and promoters, plans to integrate fan-shot video with studio-quality audio, a festival download model that could let you leave with the full day’s sets in your pocket, and the untapped archive of legendary performances that are sitting in mixing engineer hard drives around the world waiting to be released. The US launch is coming, the opportunity is colossal, and the answer to why nobody has done this yet may simply be: nobody thought of it until now.

Learn more about Setmixer at setmixer.com and reach us with comments or questions at theangelnest.com.

Drones have been consumer products for years, but entrepreneurs are now finding their commercial potential. New ideas are coming fast, and few are as ambitious as SkyFire. In this New York Angels edition of The Angel Nest, we meet Don Mathis, a former Navy flight officer who watched drones change the course of modern warfare in Ukraine and decided it was time to build something bigger at home. SkyFire is a platform that deploys sophisticated Level 2 drones to enhance public safety, streamline business logistics, support national defense, and even deliver medicine to patients who need it most. Joining Don are Bob Peck and Alyssa Tam, New York Angels members who co-led SkyFire’s seed investment round. They’ll share what drew them to the company out of a crowded drone market, how the NYA Sidecar Fund helped amplify the investment, and why SkyFire has more levers to pull than most startups they see. We’ll also talk AI, international ambitions, and what the next year holds for one of the most versatile companies in the portfolio. Learn more about SkyFire and see who the New York Angels are partnering with at newyorkangels.com.

And, listen to more great interviews from our series with the New York Angels at https://theangelnest.com.