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SetSet with April Pride

SetSet with April Pride

Von: April Pride
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 SetSet supports women exploring psychedelics. This show is intended for anyone seeking transformation with the assistance of psychoactive substances. If you're looking to "trip" with friends or "journey" with a trained facilitator, SetSet offers practical, seasoned insights to help you optimize the potential of your next experience. Host April Pride shares expert knowledge, anecdotal stories, and data-backed resources for listeners, including as they integrate their insights and discoveries from expanded consciousness.

aprilpride.substack.comApril Pride Alternative & Komplementäre Medizin Hygiene & gesundes Leben Persönliche Entwicklung Persönlicher Erfolg
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  • Microdosing for Midlife — Week 4: Stability, Change, and the Nervous System

    Microdosing for Midlife — Week 4: Stability, Change, and the Nervous System
    Feb 24 2026

    121. Microdosing for Midlife: Stability & Nervous System Change (Week 4)

    Week 4 of Microdosing for Midlife explores how nervous system stability shapes identity, growth, and long-term change in midlife.

    Episode Summary

    This episode is part Week 4 of Microdosing for Midlife—a 12-part audio companion to the original Substack series.

    In this conversation, April expands on what it actually means to feel stable while undergoing change. Midlife often brings visible transitions—shifts in hormones, identity, relationships, ambition—but underneath those external markers is something quieter: the nervous system recalibrating itself. Rather than focusing on dramatic breakthroughs, this episode examines how safety, steadiness, and subtle internal shifts create sustainable growth.

    Instead of chasing intensity, April reflects on how microdosing can support capacity—capacity to tolerate discomfort, to remain present in uncertainty, and to integrate insight gradually. The real work is not in peak moments. It’s in the ability to return to baseline without abandoning yourself.

    🔵 Key Takeaways

    How nervous system stability shapes long-term growth in midlife

    Why intensity is often mistaken for progress

    How subtle shifts accumulate into meaningful identity change

    What “capacity building” looks like beyond insight

    A reflection question to carry into the week ahead

    🔵 Timestamps

    [00:00] Episode opening[02:00] Framing the week’s theme[08:30] Nervous system stability vs intensity[15:00] Capacity building in midlife[22:00] Integration reflection[27:00] What to carry forward

    🔵 Resources

    Micro-Psyched 12-Week Microdosing Program

    Upcoming Psychedelic Salon tickets

    Follow April on Substack

    Original Microdosing for Midlife Substack post:https://aprilpride.substack.com/p/vagus-nerve-menopause-psilocybin-intuition-body-trust

    Hosted by April Pride @aprilpride_

    Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset



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    18 Min.
  • Microdosing for Midlife, Week 3: Hormones, Perception, and Libido in Menopause

    Microdosing for Midlife, Week 3: Hormones, Perception, and Libido in Menopause
    Feb 17 2026

    120. Microdosing for Midlife: Hormones, Perception, and Libido (Week 3)

    Exploring how menopause, perception shifts, and nervous system regulation intersect with midlife libido.

    Episode Summary

    This episode continues Week 3 of Microdosing for Midlife, April Pride’s 12-part audio companion to her Substack series exploring microdosing through the lens of midlife transition.

    In this conversation, April examines one of the most quietly asked questions among women in perimenopause and menopause: can microdosing influence hormones or libido? Rather than positioning psilocybin as a hormonal intervention, she reframes the inquiry around perception, serotonin signaling, emotional regulation, and nervous system safety.

    The episode explores how estrogen fluctuations affect mood stability, why cortisol and stress patterns shape desire, and how subtle perceptual shifts—rather than dramatic sensations—may influence connection and intimacy. Through personal reflection and grounded science, April centers integration over hype.

    🔵 Key Takeaways

    • Sub-perceptual microdosing is about perception shifts, not noticeable psychedelic effects• Estrogen plays a role in serotonin regulation and emotional stability• Hormonal fluctuations in midlife can increase anxiety and mood vulnerability• Libido is influenced by stress regulation and psychological safety• Psilocybin research currently focuses on emotional systems—not hormone “balancing”• Interoception (body awareness) may shift during midlife transitions• Structured integration matters more than isolated insight

    🔵 Timestamps

    [00:00] Episode disclaimer and introduction[01:00] The neurobiology of change and structured microdosing[02:00] Sensation vs. perception in microdosing[04:00] Rewriting grief narratives and identity shifts[05:00] Estrogen, serotonin, and cortisol interactions[06:30] Oxytocin, connection, and emotional openness[08:00] Interoception and body awareness[09:00] Libido and menopause[10:00] Emotional safety and renewed desire[11:00] Closing reflections

    🔵 Additional Resources

    Micro-Psyched Microdosing Guide

    Original Week 3 post on Substack

    Women in the Wild - Reserve your spot!

    Learn more about this episode: https://aprilpride.substack.com/p/microdosing-for-midlife-week-3-hormones-libido

    Hosted by April Pride

    Subscribe for April’s newsletter on Substack at https://aprilpride.substack.com/subscribe or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset



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    12 Min.
  • Microdosing for Midlife, Week 2: Brain Science of Change

    Microdosing for Midlife, Week 2: Brain Science of Change
    Feb 11 2026
    119. Microdosing for Midlife: Brain Science of Change (Week 2)Week 2 of Microdosing for Midlife explores estrogen, menopause, hormone therapy, and cognitive health—plus how psilocybin supports neuroplasticity.Episode SummaryThis episode marks Week 2 of Microdosing for Midlife, a 12-week audio series exploring how psilocybin microdosing for women intersects with hormonal change, emotional regulation, and cognitive resilience during midlife.In this installment, April Pride expands on a central question that surfaced after Week 1: whether being “spared” classic menopausal symptoms—or choosing not to take hormone replacement therapy—puts women at greater risk for cognitive decline. Drawing from current research, April reframes the fear-driven narrative around menopause, estrogen, and dementia, offering a more nuanced and reassuring understanding of what actually shapes long-term brain health.The episode also explores estrogen’s role as a neuroprotectant, how the midlife brain becomes more vulnerable to stress-based patterning, and why psychedelics like psilocybin may support neuroplasticity by softening rigid survival scripts. Through personal reflection and lived experience, April illustrates how subtle shifts in perception—not emotional erasure—can change one’s relationship to anxiety, grief, and uncertainty.This episode functions as an audio companion to the written Week 2 essay, adding scientific context, integration insights, and real-life application without replacing the original post.🔵 Key Takeaways• Menopause as a neurological transition, not just a hormonal one• Estrogen’s role in cognition, mood, and neuroprotection• Why high symptom burden—not absence of symptoms—is linked to later cognitive risk• What hormone therapy does and does not do for long-term cognition• The default mode network and midlife rumination patterns• Psychedelics, neuroplasticity, and loosening fear-based survival scripts• Microdosing as a tool for integration rather than emotional suppression🔵 Timestamps[00:00] Reflections on Psychedelic Salon and Women in the Wild[02:30] Introducing Week 2 and the HRT cognition question[03:45] Menopausal symptoms and cognitive risk[05:00] What hormone therapy research actually shows[06:30] Estrogen as a neuroprotectant[08:30] Brain changes during midlife[10:00] Psychedelics and neuroplasticity[11:30] Personal reflections on anxiety and action[13:30] Reflection questions for listeners[15:00] Micro-Psyched program overview and what’s next🔵 Additional ResourcesOriginal Week 2 post on SubstackEpisode 55: Ketamine-Assisted Therapy: Brain Effects ExplainedWomen in the Wild - Reserve your spot! Learn more about this episode: https://aprilpride.substack.com/p/microdosing-for-midlife-estrogen-cognitionHosted by April PrideSubscribe for April’s newsletter on Substack at https://aprilpride.substack.com/subscribe or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset Get full access to SetSet with April Pride at aprilpride.substack.com/subscribe
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    17 Min.
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