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Dr. Karsten Eastman, Ph.D. is the CEO and Co-Founder of Sethera Therapeutics ( https://setheratx.com/ ), a company focused revolutionizing peptide-based drug development with a cutting-edge enzymatic cross-linking technology, and their platform enables the synthesis of highly stable, polymacrocyclic peptides designed to engage multiple targets simultaneously, offering unparalleled precision in therapeutic design.

Trained as a chemist at the University of Utah, where he earned his PhD in 2023, Dr. Eastman has built his career at the intersection of peptide synthesis, protein engineering, and radical enzymology. His work focuses on understanding how enzymes choreograph complex molecular transformations — and then harnessing those principles to build programmable, drug-like molecules.

In collaboration with researchers at the University of Utah, Dr. Eastman and his team recently published in Proceedings of the National Academy of Sciences a breakthrough discovery involving PapB, a radical S-adenosyl-L-methionine (SAM) enzyme capable of installing precise, durable thioether “staples” into peptides in a single enzymatic step. This work opens vast new chemical space for macrocyclic peptide therapeutics and offers a powerful new approach to targeting diseases long considered “undruggable.”

At Sethera Therapeutics, Dr. Eastman is translating this enzymatic platform into next-generation peptide medicines that aim to combine the selectivity of biologics with the drug-like properties of small molecules.

#PeptideTherapeutics #DrugDiscovery #Biotechnology #Enzymology
#RadicalSAM #PapB #SetheraTherapeutics #UndruggableDiseases
#MacrocyclicPeptides #Bioengineering #Therapeutics #Innovation #ScienceBreakthrough #PeptideDrugs #EnzymeTechnology

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Susie Singer Carter ( https://en.wikipedia.org/wiki/Susie_Singer_Carter ) is an award-winning filmmaker ( https://www.gogirlmedia.com/ ) and caregiver advocate with a powerful new docuseries, No Country For Old People ( https://www.amazon.com/gp/video/detail/B0F7D1RR5X/ref=atv_dp_share_cu_r ), a Gold Anthem Award-winning exposé on nursing home neglect and the systemic failures facing America’s elderly. Through film, podcasting, and activism, she has become one of the most compelling creative voices in Alzheimer’s awareness and elder care reform.

Susie first captured international attention with her Oscar-qualified short film My Mom and The Girl, starring Valerie Harper in her final performance — a deeply personal story born from Susie’s own caregiving journey.

From writing and producing Bratz the Movie, to co-producing Soul Surfer, Susie has navigated Hollywood at every level — but it’s her advocacy-driven work that has become her defining voice.

Susie is also the creator and host of the award-winning podcast Love Conquers Alz ( https://podcasts.apple.com/us/podcast/love-conquers-alz/id1492023291 ), and she serves as host of the 3rd & Fairfax for the Writers Guild of America West.

Most recently, Susie wrote, directed, and produced the 3-part docuseries No Country For Old People ( https://www.youtube.com/watch?v=Loa4tGZ3GwI ), recipient of the 2024 Gold Anthem Award for Health Awareness. The film is a searing examination of nursing home neglect, systemic healthcare failures, and the human cost of institutional indifference — a subject she knows not just as a filmmaker, but as a daughter who lost her mother to Alzheimer’s.

Susie also leads Respect Oversight Advocacy Reform for Long Term Care ( https://www.roar4ltc.org/ ) a 501c3 nonprofit movement that is embracing the power of storytelling to engage and mobilize the public, with a strong focus on younger generations, to demand dignity, accountability, and reform in long-term care.

Susie Singer Carter doesn’t just tell stories. She uses them to fight for change.

Important Episode Links

No Country For Old People; a Nursing Home Exposé -

https://www.amazon.com/gp/video/detail/B0F7D1RR5X/ref=atv_dp_share_cu_r

http://nocountryforoldpeople.com/

https://www.youtube.com/@UCZGC8Htb549M2TNVSR67FOw

My Mom and the Girl - https://vimeo.com/266772460

Respect Oversight Advocacy Reform for Long Term Care - https://www.roar4ltc.org/

#SusieSingerCarter #NoCountryForOldPeople #ElderCare #NursingHomeCrisis #CaregiverAdvocacy #AlzheimersAwareness
#HealthcareReform #DementiaCare #PublicHealth #AgingPopulation
#LongTermCare #HealthPolicy #CaregiverLife #ElderJustice #Longevity

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Why do some scientific breakthroughs begin with ridicule?
In this episode, we explore cancer research, serendipity, and the philosophy behind unconventional biomedical innovation.

Dr. Alexander Shneider, Ph.D. is a biotech entrepreneur and scientist with more than three decades of experience spanning oncology, immunology, vaccines, and translational medicine. He is the Founder and CEO of CureLab Oncology ( https://www.curelaboncology.com/ ), where he is leading the development of a novel biological agent designed to fight cancer through a dual approach—stimulating anti-tumor immunity while also addressing the chronic inflammation that often underlies disease progression.

CureLab’s lead therapeutic, Elenagen, has demonstrated a strong safety profile and encouraging signals of clinical benefit in international Phase II studies, and is being explored both as an adjunct to standard cancer treatments and for its broader potential in inflammation-driven and age-associated diseases. The platform’s reach may extend beyond human medicine, with ongoing interest in applications for oncology in companion animals.

Over the course of his career, Dr. Shneider has advised biotechnology, pharmaceutical, and investment organizations across areas including R&D strategy, licensing, technology transfer, product development, and intellectual property. He previously founded CureLab, Inc., where he worked on tools for the rational design of DNA vaccines and the development of broad-spectrum influenza vaccine concepts.

In academia, Dr. Shneider has held professor-level appointments and led the Genetic Vaccine Laboratory at Sechenov University, where he helped establish multicenter clinical research infrastructure focused on diseases involving chronic inflammation. His research has also explored evolutionarily conserved RNA structures as targets for antiviral therapies and next-generation vaccine design.

In addition to his scientific and entrepreneurial work, he serves on the editorial boards of several peer-reviewed journals in immunology and aging research, reflecting his long-standing engagement at the intersection of basic science, clinical translation, and biotechnology innovation.

#CancerResearch #BiomedicalScience #CancerInnovation
#ScientificDiscovery #PhilosophyOfScience #Biotech #MedicalInnovation
#Oncology #BreakthroughScience #StartupScience #SciencePodcast #DrugDevelopment #Serendipity #Innovation #FutureOfMedicine

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