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Let's Talk Wellness Now
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 Deep Health, Real Answers - hosted by Dr. Deb Ökonomie
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  • Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More!

    Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More!
    Mar 3 2026
    Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire ...
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    37 Min.
  • Episode 255 – Advancements in naturopathic medicine and whole-body healing

    Episode 255 – Advancements in naturopathic medicine and whole-body healing
    Feb 2 2026
    Dr. Deb Muth 0:03Welcome back to let’s Talk Wellness. Now, I’m your host, Dr. Deb. If you’re a woman who’s doing everything right, eating clean, exercising, taking supplements, yet you still feel exhausted, inflamed, or like your body suddenly stopped cooperating, this episode is for you. Today’s conversation challenges one of the biggest myths in women’s health. That midlife struggles are just about hormones or worse, just part of aging. My guest today is Dr. Deb Heald, a naturopathic physician with one of the most fascinating backgrounds I’ve ever encountered. Yeah, she’s got a really diverse background, which is kind of exciting. She’s been an ER nurse, a stockbroker, a Silicon Valley data analysis, teaching machines to learn from microbiome research. And yes, she holds an mba, too. But it was her own menopause crash that changed everything. When the protocols she had been teaching stopped working for her, her, she didn’t double down on templates or trends. She did what she was trained to do. She followed the data and what she discovered reframed menopause, metabolism and women’s longevity in a completely different way. This isn’t about willpower. It’s not about another diet, and it’s definitely not about copying what worked for someone else. It’s about learning to listen to your body and finally understanding what it’s been trying to tell you and all along. So grab your cup of coffee or tea, settle in, and let’s dive into this amazing conversation about women’s health and menopause. And right after our guest is arriving with us, we’re going to get a word from our sponsor quick here. And then we are going to come right back to having this conversation with Dr. Deb Heald. Ladies, it’s time to reignite your vitality. Primal Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that lasts. Get 25% off@primal queen.com Serenity Health. Because every queen deserves to feel in her prime. But okay. All right. Welcome back, everybody. I am here with my new friend, Dr. Deb Heald. And she has such an amazing background, like I shared with you a few minutes ago. But I would love for her to give us her insight in how she got where she did, because it’s rare that you find somebody with a data background and a medical background. So, Dr. Dove, welcome. Dr Deb Heald 2:30Thank you. I am so glad to be here, and it’s a real privilege to meet you. Dr. Deb Muth 2:34I feel the same way. Dr Deb Heald 2:35Yeah, it’s. I think that the more of us that start to think and practice this way, the easier it’s going to be for women going forward. Because it’s not easy. Dr. Deb Muth 2:44It is not easy. I mean, I’ve been in this industry a long time, over 25 years. And every time I think it’s getting easy, it’s getting harder for a variety of reasons. It’s the medical system, it’s the. The clients we work with are sicker. It’s taking longer to get them to a place where they feel good. There’s just so many variables these days. So tell me a little bit about what got you here. Dr Deb Heald 3:06Well, I made the decision when I was graduating from high school to be a nurse instead of a teacher, because those were really still the two options that were common for women. I thought about medicine at that point, but my sister convinced me that if I would spend all that time learning and practicing medicine, I might not be as good of a mom. So I took the path of nurse, because nurse works around kids schedules and that sort of thing. I’d only been practicing about six months before I thought, oh my gosh, there has to be more to it than this, and toyed with the idea of starting med school at that point, but then married and started having children, and I just sort of fell into that pattern. But I typically work emergency room. There was a short stent in the post anesthesia recovery room as well. And emergency room was a place where western medicine actually shone. Right. People come in, they are no longer capable of functioning, they’re having a heart attack, they lost limb. Whatever else, they do need the, the bells and the whistles of western medicine. But when you think about it, western medicine was derived out of the Civil War where you didn’t have to say what’s the cause of the problem. It was a bullet or a bayonet, and it was, it was about patching up the soldiers and getting them back on the front line so they could continue to fight. And naturopathic medicine, which had been a lot around for an awful lot longer than that, just didn’t work in the battlefield then. The assessment was done in the early 1900s as to which style of medicine got people back to work faster. The Flexner report was all about how corporations could maximize the value of employees. And naturopathic medicine didn’t win because nutritional fixes take a long time. Taking away somebody’s stress so that they can just function more ...
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    50 Min.
  • Episode 256 – How Peptides Work, Benefits, and FDA-Approved vs Off-Label Use Explained

    Episode 256 – How Peptides Work, Benefits, and FDA-Approved vs Off-Label Use Explained
    Feb 27 2026
    What if the reason you’re not healing isn’t that you need another diagnosis? 0:08 It’s that your cells aren’t receiving the right signals. Because the body doesn’t run on diagnosis, it runs on 0:16 communication. And peptides are one of the most powerful, most misunderstood 0:21 tools we have for cellular signaling, immune balance, tissue repair, gut 0:27 lining support, metabolic control, brain signaling, sleep cycles, and even sexual 0:35 wellness. Today, I’m going to do what most people won’t. Define peptides in 0:41 plain English for you. break them into categories by what they’re best at and 0:47 tell you which ones are FDA approved on the list and which ones are commonly 0:53 used off label or investigational with the evidence that actually says these 1:00 work. This is going to be a powerful episode and if you’ve ever felt like you’re hearing hype without clarity, 1:07 this one’s for you. So, as usual, grab your cup of coffee or tea and settle in 1:13 as we talk about peptides that can fit into your healing journey. We’re going 1:19 to have a short word from our sponsor. You know, we got to do that. That’s how we stay on the air here. So, we will be 1:26 right back after this. Did you know sweating can literally heal your cells? 1:32I nfrared saunas don’t just relax you. They detox your body, balance hormones, 1:37 and boost mitochondrial energy. I’m obsessed with my health tech sauna. And 1:42 right now, you can save $500 with my code at healthtechalth.com/drmuthqen25. 1:54 All right, here we go, guys. I am excited to dive into peptides with you. 2:00 So understanding peptides is foundational, right? And I’ve been 2:06 studying peptides now for about nine years. Um, and I find that they are 2:13 incredible. Um, so I want to break down for you what peptides actually are, what 2:19 they do, and some of the top peptides that are available today, and how they 2:25 can be utilized. Because I think it’s really important. And I think it’s it’s there’s a lot of confusion out there about what these things actually are and 2:32 are they safe? Are they not? When do we use them? What’s the science behind them? So, we’re going to dive in and 2:38 we’re going to talk about all things peptides. So, let’s get ready here. Here we go. So, peptides are short chains of 2:45 amino acids and they typically range anywhere from 2 to 50 amino acids and 2:51 they’re linked by peptide bonds. So think of them as the superglue that holds the amino acids together. They sit 2:58 between the amino acids and they are full proteins in terms of their size and 3:04 their complex structure. And what makes peptides particularly interesting in 3:10 medicine is their role as signaling molecules. They’re essentially the 3:15 body’s text messages carrying specific instructions to cells and tissues. And 3:21 unlike our proteins which often serve as structural roles or act as enzymes, 3:28 peptides typically function as hormones, neurotransmitters and growth factors and 3:33 they bind to specific receptors on the cell’s surfaces or within the cells and 3:39 they trigger this effect. It’s like a cascade effect of a biochemical reaction 3:45 that ultimately changes the cellular behavior. So basically, it’s changing 3:50 the way the body’s cell structure acts. And this is why peptides can be so 3:56 incredibly powerful and therapeutic when you introduce the right peptide signal. 4:02 Now, you could theoretically redirect cellular processes toward healing, 4:07 towards metabolism, immune balance, tissue repair. Any of those things can 4:14 be manipulated to do a certain thing once we add the peptide. The challenge 4:19 in peptide medicine though lies in distinguishing between those peptides that have been rigorously studied, 4:26 proven safe and effective and approved by regulatory bodies like the FDA versus 4:31 those that exist in what we call the gray zone of a promising clinical data. 4:36 But they really lack human validation so far. And this distinction is critical because the presence of a plausible 4:43 mechanism does not guarantee safety or efficacy in living humans. So, this is 4:50 really important and we’re going to dive in and look at some of the research on all of these different peptides that are 4:56 available and I’m excited to say there’s some amazing peptides being studied right now that unfortunately are not 5:01 available. But I can’t wait to see them hit the market for us because it is going to be a gamecher as far as health 5:09 and longevity. So there is a quality control issue and there is a hidden 5:14 variable in peptide medicine with this and it’s one of the most underappreciated aspects of peptide 5:21 therapy particularly for non-FDA approved peptides. It’s quality control. 5:26 When we discuss pharmaceutical medicines, we take for granted that the pill contains what the label says. Not 5:32 always true depending on where it comes from. ...
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    42 Min.
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