What happens when a world class chemist studies a molecule for twenty years and then finally takes it himself? In this episode of Ibogaine Uncovered, host Talia Eisenberg speaks with Dr. Dalibor Sames about the science of ibogaine, its unique pharmacology, and what it reveals about the future of mental health treatment.

Dr. Sames explains why ibogaine does not fit into traditional pharmacology models and introduces his matrix pharmacology theory, describing how the molecule interacts with many systems at once rather than a single receptor. The conversation covers synaptic repair, neurotrophic factors like GDNF, antidepressant effects, and why ibogaine shows efficacy across addiction, depression, PTSD, and TBI. In the second half, Dr. Sames describes his time at Beond as both participant and observer, including vivid visual phenomena, an unexpected moment where he felt he could “see” molecular structures, and the takeaway he emphasizes after watching clients transform in real time: this is powerful technology and scaling it demands responsibility.

Dr. Dalibor Sames is Professor of Chemistry at Columbia University, where his group combines molecular design, organic synthesis, and pharmacology to develop CNS therapeutics that induce restorative neuroplasticity, as well as tools for imaging synaptic function. He is also a cofounder of Gilgamesh Pharmaceuticals and Kures, Inc., translating discoveries from his lab into clinical development.

Timestamps

• (00:05:00) GDNF and neurorestoration: why synapses became the entry point

• (00:08:00) Skepticism vs the clinical reports: breakthrough medicine or snake oil

• (00:10:00) The “empty screen” problem: why standard receptor panels did not explain it

• (00:12:00) Matrix pharmacology: the Manhattan traffic grid analogy for how it works

• (00:15:00) Why analogs: cardiac risk, access, and the ethics of redesigning nature

• (00:20:00) Serotonin transporter and pharmaco chaperoning: unusual protein folding effects

• (00:22:00) “Meets you where you are”: individuality of experience and doing science on subjectivity

• (00:25:00) Why take it now: what changes when the scientist becomes the participant

• (00:33:00) Pre Beond phenomena: the African face vision and possible explanations

• (00:40:00) The Beond journey: projections, maintaining baseline awareness, and asking for molecules

• (00:47:00) Beond as living lab: observing client transformations and the responsibility to scale safely

• (00:54:00) Closing thesis: duty, antibiotics analogy, and what comes next

What happens when one of the world’s leading voices on detoxification and the gut brain connection experiences Ibogaine? On this episode, Talia Eisenberg sits down with Dr. Alejandro Junger to explore the scientific mechanisms behind Ibogaine and its potential to reset the entire nervous system.

Dr. Junger explains how Ibogaine interacts with neurotransmitters, neuroplasticity, and the enteric nervous system. He describes why the gut contains more neurons than the brain in the skull, how noribogaine may influence inflammation and mood, and why repairing the intestinal wall is central to long term mental health. The conversation focuses on the biology of depression, the critical role of the microbiome, and the risks and safety protocols around Ibogaine. Dr. Junger also shares how Ibogaine shifted his own depressive physiology.

Dr. Alejandro Junger is a triple board certified physician in internal medicine, cardiology, and functional medicine. He is the bestselling author of Clean, Clean Gut, Clean Eats, and Clean Seven.

Links

• Dr. Alejandro Junger's 21-Day Cleanse Program
• Alejandro Junger: books, biography, latest update
• Alejandro Junger MD (@dralejandrojunger)

Timestamps

• (00:00); Intro, Alejandro’s background and visit to Beond
• (10:00); Divorce, survival mode, anger and the slide into depression
• (16:00); Early Ibogaine work in Mexico and his first non visionary Ibogaine session
• (21:00); Avoiding antidepressants, choosing Ibogaine, and the intention to forgive
• (25:00); Open heart surgery, cardiac risk, and ibogaine vs noribogaine explanation
• (30:00); Supplemental dose, sudden emotional shift, and relief of depressive heaviness
• (35:00); Three brains model – head, gut, heart and the gut as an intuitive brain
• (41:00); Leaky gut, microbiome, chronic inflammation and modern chronic disease
• (48:00); Ibogaine for personal growth vs crisis and witnessing veteran transformations at Beond
• (58:00); Combining Clean gut repair protocols with Ibogaine before, during, and after treatment
• (01:10:00); Future of centers, human connection, and where to find Dr. Junger’s work

From combat missions to psychedelic legislation, Adam Marr has lived the full spectrum of service.

In this episode of Ibogaine Uncovered, host Talia Eisenberg sits down with the Apache helicopter pilot turned veteran advocate to explore how personal trauma led him from the battlefield to the frontlines of mental health reform.

Adam shares his journey through military service, family tragedy, and profound psychedelic healing. He recounts his first experiences with Ayahuasca, Ibogaine, and 5-MeO-DMT, and how these medicines catalyzed a spiritual rebirth that later informed his national advocacy work. Together, he and Talia trace the evolution of veteran-centered psychedelic programs, the creation of Beond Service, and the landmark policy initiatives that are reshaping access to healing for veterans and their families.

Adam Marr is a former U.S. Army Apache helicopter pilot and co-founder of the Warrior Angels Foundation. He serves on the leadership team of the Veteran Mental Health Leadership Coalition, helping to shape national policy and expand access to psychedelic-assisted therapies for veterans. Marr has also been instrumental in developing Beond Service, a comprehensive healing program at Beond that combines Ibogaine treatment with integration and family support.

Timestamps:

• (00:00) – Introduction and Adam’s path from combat pilot to advocate
• (02:15) – Meeting Talia in Kentucky and the emotional testimony that connected them
• (03:45) – Childhood, military upbringing, and joining ROTC after 9/11
• (07:00) – Deployment to Iraq and the emotional toll of missing family milestones
• (11:15) – Returning home and witnessing his brother’s decline after TBI and PTSD
• (17:30) – The broken military medical system and discovery of alternative treatments
• (20:00) – Founding the Warrior Angels Foundation and appearing on Joe Rogan
• (25:00) – First experiences with Ayahuasca and early lessons in surrender
• (30:00) – Personal burnout, family crisis, and turning to Ibogaine for healing
• (33:00) – Ibogaine visions, subconscious healing, and spiritual awakening through 5-MeO
• (41:00) – Integration challenges and learning the importance of support
• (45:00) – Building the Veteran Mental Health Leadership Coalition
• (54:00) – Founding Beond Service and creating holistic veteran and family cohorts
• (01:08:00) – Closing reflections on service, faith, and the ripple effect of healing