Fit For Science Titelbild

Fit For Science

Fit For Science

Von: Stephan Reichl and Rob ter Horst
Jetzt kostenlos hören, ohne Abo

Nur 0,99 € pro Monat für die ersten 3 Monate

Danach 9.95 € pro Monat. Bedingungen gelten.

Über diesen Titel

 Two scientists discuss how they live their best life, using science, data, tech, wearables, and systems. Fit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise in the health and fitness industry. The Quantified Scientist (Rob): youtube.com/TheQuantifiedScientist Stephan's Website: http://polytechnist.meStephan Reichl and Rob ter Horst Hygiene & gesundes Leben
Folgen
  • AI is Changing Wearables in 2026(?) and Predicts 130 Diseases from Sleep! (Fit For Science Episode 8)

    AI is Changing Wearables in 2026(?) and Predicts 130 Diseases from Sleep! (Fit For Science Episode 8)
    Jan 26 2026
    Rob and Stephan evaluate current AI features in wearables, break down a revolutionary paper predicting diseases from a single night of sleep, and discuss the future of medical integration into wearables.📝SummaryIn this episode, biological data scientists Rob and Stephan critically assess the current use of AI in the wearable market, ranging from the practical limitations of Oura and Whoop coaches to the potential of Google’s Gemini and Withings’ biomarker-tracking devices. The central scientific discussion focuses on "SleepFM," a groundbreaking foundation model published in Nature Medicine that utilizes self-supervised learning on polysomnography data to predict over 130 diseases, biological age, and mortality risk from a single night of sleep with unprecedented accuracy. The hosts speculate on how this technology could bridge the gap between clinical sleep labs and consumer wearables, potentially transforming preventive medicine through longitudinal tracking and non-invasive sensors.⏳Chapters00:00:00 AI in wearables and their current capabilities00:01:21 AI Coaches: Testing the limits of Oura, Whoop, and Garmin 00:12:24 The Smart Toilet: Withings U-Scan and the value of waste biomarkers 00:23:00 Environmental Health: PVC off-gassing and vinyl records 00:28:15 Generative AI: ChatGPT Health and Claude for Life Sciences 00:37:17 SleepFM: A multimodal sleep foundation model for disease prediction 00:43:00 Self-Supervised Learning: How foundation models learn from sleep data 00:51:00 Disease Prediction: Predicting 130 conditions with unseen accuracy00:59:46 The Future: Translating clinical models to consumer wearables 01:19:25 Community Feedback📚ResourcesIntroducing Oura Advisor (not Coach)WHOOP Coach Powered by OpenAIActive Intelligence With Garmin Connect+U-Scan NutrioNews: Withings latest smart scale (‘longevity station’)Withings IntelligenceBody ScanKetone bodiesKetosis: Definition, Benefits & Side EffectsKeto Breath (“dragon breath”)Air Quality Measurement DeviceVINYL: Maybe it's time we had an intervention.Introducing ChatGPT HealthSegment about AI in health(care)Claude in healthcare and the life sciencesClarification: Anthropic's product is called Claude with three differently sized models named Haiku, Sonnet, and Opus.ICD-10 and ICD-11 Codes: International Classification of Diseases (ICD)Understanding ICD-10 | Johns Hopkins MedicineHealthcare Spending - Our World in DataFederated learningSwarm LearningSleepFM - Nature Medicine paperCodeStanford Sleep Bench v1.0Foundation modelAttention Is All You Need (Transformers)Self-supervised learningImageNetFine-tuningReinforcement learning from human feedback (RLHF)PolysomnographyRecurrent neural network (LSTM)Long short-term memory (RNN)C-index: Evaluating Survival ModelsBest Wearables for Sleep: Scientific Rankings (2024-05)Best Wearables for Sleep: Scientific Rankings (2025-10)Philips Somnolyzer 24x7 for automated sleep stagingWhoop listened(?) and is looking for a VP for Foundation AIAUROC of blood pressure to predict ASCVD ~0.80Podcast Recommendation: Drug Story Atorvastatin (Lipitor)Life expectancy: Netherlands (82.2) vs Austria (82.0)Diagnostic and Statistical Manual of Mental Illnesses (DSM-5)Mechanism does not imply outcome. Outcome implies mechanism. - Layne NortonNo Biological Free Lunches🎙️AboutFit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise in the health and fitness industry.Learn more and subscribe on your favorite platforms:YouTubeSpotifyApple PodcastsAmazon Music⚠️Disclaimer: This podcast represents our own opinions and is for informational purposes only. It does not constitute medical or financial advice or a professional relationship.
    Mehr anzeigen Weniger anzeigen
    1 Std. und 25 Min.
  • The 4 Types of Wearables! Epigenetic Aging & Peakspan vs Healthspan? (+ Enhanced Games) (Fit For Science Episode 7)

    The 4 Types of Wearables! Epigenetic Aging & Peakspan vs Healthspan? (+ Enhanced Games) (Fit For Science Episode 7)
    Jan 19 2026
    Rob and Stephan categorize the modern wearable landscape, explain the shift from epigenetic to proteomic aging clocks, and debate the ethical implications of the upcoming 2026 Enhanced Games.📝SummaryIn this episode, biological data scientists Rob and Stephan provide a systematic framework for navigating the wearable market by defining four distinct device categories: Sleep, Sports, Smartwatches, and Health, while highlighting the technical trade-offs between battery life, GPS robustness, and algorithmic precision. The discussion transitions into the cutting-edge science of biological aging, contrasting traditional epigenetic methylation clocks with emerging organ-specific proteomic models that offer greater interpretability and more actionable insights for disease prevention. They introduce the concept of Peakspan, a proposed metric for maintaining 90% of optimal physiological performance throughout life, and conclude with a deep dive into the 2026 Enhanced Games, exploring the transhumanist debate over the supervised use of performance-enhancing drugs in professional sports.⏳Chapters00:00:00 The Four Wearable Archetypes: Sleep, Sports, Smartwatch, and Health 00:11:53 Software vs. Hardware: Why Tech Giants Lead in Heart Rate Accuracy 00:24:54 Decoding Biological Age: Epigenetic Clocks and Methylation Patterns 00:40:59 The Proteomic Shift: Using Organ-Specific Clocks to Predict Morbidity 00:51:09 Beyond Healthspan: Defining Peakspan at the 90% Performance Threshold 01:03:14 Cognitive Aging: Fluid vs. Crystallized Intelligence 01:12:22 Enhanced Games 2026: The Transhumanist Future of Competitive Sports 📚ResourcesEpigenetics - Wikipedia Unfolded, the DNA in a single human cell is about 2 meters (6.5 feet) long, containing roughly 3 billion base pairs.Steve Horvath's Epigenetic clock - WikipediaThe first/original clock was actually based on DNA methylation levels in saliva, not blood.An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes | Nature Communications DNA methylation GrimAge strongly predicts lifespan and healthspan - PMC CeMM: Landsteiner LecturesProtein-based organ aging clock research Tony Wyss-Coray, PhDAmino acid - WikipediaDunedinPACE, a DNA methylation biomarker of the pace of aging - PMC Amazing TIME article about biological age (published after recording 16.01.2026) The Race to Measure How We Age | TIME -omics: Proteomics & GenomicsMayo Clinic Q and A: Lifespan vs. healthspan Peakspan preprint paperFluid and crystallized intelligence - WikipediaTranshumanism - Wikipedia Enhanced Games 2026🎙️AboutFit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise in the health and fitness industry.Learn more and subscribe on your favorite platforms:YouTubeSpotifyApple PodcastsAmazon Music⚠️Disclaimer: This podcast represents our own opinions and is for informational purposes only. It does not constitute medical or financial advice or a professional relationship.
    Mehr anzeigen Weniger anzeigen
    1 Std. und 30 Min.
  • Is “Biological Age” Useful According to Science? Systematic 2026 Outlook & 2025 Year Review (Fit For Science Episode 6)

    Is “Biological Age” Useful According to Science? Systematic 2026 Outlook & 2025 Year Review (Fit For Science Episode 6)
    Jan 14 2026
    Rob and Stephan analyze their 2025 health data, discuss the validity of "biological age" metrics, and set systems-based goals for the coming year.📝SummaryIn this episode, biological data scientists Rob and Stephan explore how to use wearable data to review the past year and plan for a better future. They critique the "year in review" features of popular apps, debating whether these metrics provide actionable insights or merely gamified motivation. The discussion moves into the science of cardiovascular age and pulse wave velocity, highlighting how short-term exercise interventions might alter arterial stiffness markers. Reflecting on personal growth, Rob shares his transition from manual to more automated tracking for perceived happiness, while Stephan outlines a systematic "Past Year Review" framework to replace traditional New Year’s resolutions. The episode concludes with a look at 2026 technological trends, including the potential for better batteries, screenless GPS wearables, and new FDA regulatory pathways that could integrate consumer health tech into clinical practice.⏳Chapters00:00:00 Year in Review: Discussing App Recaps and Comparisons 00:07:47 Feedback Loops: How to Use Data Trends for Behavioral Change 00:24:48 Biological Age: Decoupling Marketing from Physiological Truth 00:35:15 Cardiovascular Age: Pulse Wave Velocity and Arterial Adaptation 00:48:57 The Importance of Controls: Lessons from a Cold Exposure Study 01:03:17 Nerve Health: Tracking Impact and Recovery via Smart Scales 01:06:54 Quitter’s Day vs. Systems: Why New Year’s Resolutions Fail 01:08:15 The Past Year Review: A Data-Driven Framework for Lifestyle Design01:12:26 2026 Goals: Marathons, Biking Rivalries, and Life Balance 01:21:10 Professional Focus: Cutting Out Distractions to Finish Projects01:23:54 One-Bag Travel: Reflections on Minimalist Gear and Efficiency 01:27:03 Future Wearables: GPS, Battery Tech, and FDA Regulation📚ResourcesOura 2025 year in reviewWhoop 2025 year in review"Comparison is the death of joy." - Mark TwainArthur C. Brooks Personality Types QuizDoctor Mike confronting Dr. Amen“Imperfect data can still have value” - Joe Barnard (from https://bps.space/)Heroic dose"Long-term consistency trumps short-term intensity." - Bruce LeeWhoop biological ageVO2max and longevityLancet Public Health: “7,000 steps/day linked to clinically meaningful health improvements.”: https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(25)00164-1/ Pulse Wave Velocity (PWV): https://en.wikipedia.org/wiki/Pulse_wave_velocity PWV relationship to blood pressure: https://www.pnas.org/doi/10.1073/pnas.1814392115 Arteries: https://my.clevelandclinic.org/health/body/22896-arteries Muscle memory in strength trainingEndurance memory exists and is driven by persistent structural adaptations (capillary density and cardiac remodeling) and epigenetic priming.“Quitter's day” is the second Friday in January.Stephan's Past Year Review instructionsStephan's backpack and packing listThe Greek philosopher Plato proposed the Theory of Forms, asserting that the physical world consists of imperfect copies of eternal, perfect, and abstract "master" templates existing in a higher realm of reality.Oura executives (CEO and CMO) on new regulatory pathway for wearables🎙️AboutFit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise in the health and fitness industry.Learn moreSubscribe on your favorite platformsYouTubeSpotifyApple PodcastsAmazon Music⚠️Disclaimer: This podcast represents our own opinions and is for informational purposes only. It does not constitute medical or financial advice or a professional relationship.
    Mehr anzeigen Weniger anzeigen
    1 Std. und 42 Min.
Noch keine Rezensionen vorhanden