For the first time in history, ovarian biological age can be measured, and I became the first woman in the world to take the test.

Until now, women have had no real way to understand how their ovaries are aging beyond rough estimates like AMH. But this new machine-learning algorithm, trained on over 40,000 real women across different life stages, analyzes hormone biomarkers, body composition, and reproductive history to estimate ovarian age relative to chronological age.

This is a massive step forward in female longevity science.

In this episode, I walk through what the test measures, how the algorithm works, and what becoming the first data point actually means, not just for me, but for women collectively. We also explore what may be driving ovarian aging in the first place.

I also share how I’m now testing specific interventions in isolation, including hyperbaric oxygen therapy, to determine whether we can meaningfully influence ovarian aging over time.

Ovarian lifespan is significantly shorter than overall lifespan and once we can measure it, we can begin to understand it.

This is only the first step in redefining female longevity.

Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.

https://kayla-barnes-lentz.circle.so/checkout/become-a-member

*Kayla's social + website:*

Instagram: https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com

Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ

Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

SHOW NOTES:

00:01:03 Timeless Biotech Website:https://timelessbiotech.com/

00:01:13 Podcast With The Founder of Timeless Biotech:https://www.youtube.com/watch?v=s-_EuNUwjsM&t=57s

00:04:12 Kayla’s Protocols:https://www.protocol.kaylabarnes.com/

00:09:58 Podcast With Dr. Chris Masterjohn:https://www.youtube.com/watch?v=z3quYW_pCDU

00:10:48 Study About Ovarian Stiffness Increasehttps://pmc.ncbi.nlm.nih.gov/articles/PMC7681059/#acel13259-sec-0002

00:16:22 Study For Increased PFAShttps://pubmed.ncbi.nlm.nih.gov/41620147/

00:17:56 Red Light Therapy Study:

https://www.sciencedirect.com/science/article/abs/pii/S1011134424001842?via=ihub

Perimenopause is not just about hormones, it’s a metabolic transition that affects insulin sensitivity, gut health, stress tolerance, and long-term disease risk.

In this episode, Cynthia Thurlow, board-certified nurse practitioner and functional medicine expert, explains how women’s metabolism changes in midlife and why insulin resistance, poor stress resilience, and gut dysfunction often appear years before menopause.

She breaks down how perimenopause can begin earlier than most women expect, why symptoms vary so widely, and how lifestyle factors like fasting, exercise intensity, sleep, alcohol, and chronic stress interact with hormones during this transition.

Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member

This conversation explores:

• Why insulin resistance often emerges in perimenopause

• How stress and trauma shape metabolic and hormonal health

• The role of gut health in PMS, mood, and estrogen balance

• When fasting helps women and when it makes things worse

• Why “doing everything right” can still lead to symptoms

• How to individualize nutrition, training, and recovery in midlife

Connect with Kayla:

Instagram:https://www.instagram.com/kaylabarnes/

TikTok:https://www.tiktok.com/@femalelongevity

Twitter:https://x.com/femalelongevity

Website:https://www.kaylabarnes.com/

YouTube: www.youtube.com/@KaylaBarnesLentz

Apple: https://podcasts.apple.com/us/podcast...Website:https://www.protocol.kaylabarnes.com

Learn more about Cynthia Thurlow

Instagram: https://www.instagram.com/cynthia_thurlow_/

YouTube: https://www.youtube.com/cynthiathurlow

Website: https://www.cynthiathurlow.com/

Pre-order her upcoming book: The Menopause Gut (28th of April 2026):https://www.penguinrandomhouse.com/books/777129/the-menopause-gut-by-cynthia-thurlow-np/?mcp…

ACE (Adverse Childhood Experiences) questionnaire:https://www.acesaware.org/wp-content/uploads/2022/07/ACE-Questionnaire-for-Adults-Identified-English-rev.7.26.22.pdf