This release contains only the music track from Base by Base Episode 325.

Song title: Beyond One Gene
Original Base by Base episode: 325: cis-pcQTL mapping reveals allelic proxitropy across neighboring human genes
Original episode link: https://basebybase.com/episodes/cis-pcqtl-allelic-proxitropy-gtex

Article metadata:
Article title: Focus on single-gene effects limits discovery and interpretation of complex-trait-associated variants
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2026.02.022
Reference: Lawrence, K.A., Gjorgjieva, T., Nachun, D., and Montgomery, S.B. (2026). Focus on single-gene effects limits discovery and interpretation of complex-trait-associated variants. The American Journal of Human Genetics 113, 1–10. https://doi.org/10.1016/j.ajhg.2026.02.022

Lyrics:
Verse 1
I stared at the numbers on a midnight screen,
One gene at a time, too narrow to see.
But neighbors were humming in a shared refrain,
Like hidden chords riding the same old strain.

Pre-Chorus
So I stepped back, let patterns take the lead,
Folded the noise into what they all agreed.
A thousand small signals started to align,
Turning scattered sparks into a single sign.

Chorus
We go beyond one gene, beyond one name,
Catch the quiet pulse that moves a whole frame.
From clustered lines, the truth comes through,
A noncoding whisper saying what to do.
And when the trait lights up, it’s not by chance—
It’s many close voices in one new dance.

Verse 2
A principal axis, a drift in the light,
Credible sets we never had in sight.
Fine-mapped footsteps in the regulatory dark,
Permuted, measured, chasing every spark.

Bridge
Not every signal tells one simple story,
Some gears turn together, subtle and blurry.
But if we follow where the loadings lean,
We find what was missed in the in-between.

Final Chorus
We go beyond one gene, beyond one name,
Pull more collocations from the GWAS flame.
From clustered lines, the truth comes through,
Distributed effects in a clearer view.
So raise the lens, let the system sing—
One neighborhood chorus, and everything.