Nicholas Spencer, charismatic head of a company involved in the development of an anticancer vaccine, suddenly disappears. His private plane crashes en route to Puerto Rico, but his body is not found. Early results of the vaccine seemed highly promising. Yet, coinciding with Nicholas Spencer's disappearance comes news that the FDA is denying approval. Then follows the shocking revelation that Spencer had looted huge sums of money - including the lifetime savings of people who had risked everything.

A young woman is haunted by two murders that are closely linked -- despite the 110 years that separate them.

Following the breakup of her marriage and her pursuit by an obsessed stalker, criminal defense attorney Emily Graham accepts an offer to work in a major Manhattan law firm. Feeling a need for roots, she buys her ancestral home in New Jersey, which her family sold in 1892, after the disappearance of young Madeline Shapley, one of Emily's forebears.

Kay Lansing grew up the daughter of the landscaper to the wealthy and powerful Carrington family. One day, accompanying her father to work, six-year-old Kay overhears a quarrel between a man and a woman that ends with the man's caustic response: "I heard that song before." That same evening, young Peter Carrington drives the 19-year-old daughter of neighbors home from a formal dinner dance at the Carrington estate, but she is not in her room the next morning and is never seen or heard from again.

Jean Sheridan, a college dean and prominent historian, sets out to her hometown to attend the 20-year reunion of Stonecroft Academy alumni, where she is to be honored along with six other members of her class. There is something uneasy in the air: one woman in the group about to be feted, Alison Kendall, a beautiful, high-powered Hollywood agent, drowned in her pool during an early-morning swim. Alison is the fifth woman in the class whose life has come to a sudden, mysterious end.

In the picturesque village of Branscombe, New Hampshire, the townsfolk are all pitching in to prepare for the first (and many hope, annual) Festival of Joy. The night before the festival begins, a group of employees at the local market learn that they have won $160 million in the lottery. One of their co-workers, Duncan, decided at the last minute, on the advice of a pair of crooks masquerading as financial advisers, not to play. Then he goes missing.