The year is 1911. Chief Investigator Isaac Bell of the Van Dorn Detective Agency has had many extraordinary cases before. But none quite like this. Hired to find a young woman named Anna Pape who ran away from home to become an actress, Bell gets a shock when her murdered body turns up instead. Vowing to bring the killer to justice, he begins a manhunt that leads him into increasingly more alarming territory.

It is 1906, and in New York City, the Italian crime group known as the Black Hand is on a spree: kidnapping, extortion, arson. Detective Isaac Bell of the Van Dorn Agency is hired to form a special Black Hand Squad, but the gangsters appear to be everywhere - so much so that Bell begins to wonder if there are imitators, criminals using the name for the terror effect. And then the murders begin, each one of a man more powerful than the last, and, as Bell discovers to his dismay, the ultimate target may be the most powerful man of all.

A no-nonsense detective is on the trail of the sharpest and deadliest criminal mind he has ever encountered: a serial robber who murders any and all witnesses in cold-blood.

It is 1907, a year of financial panic and labor unrest. Train wrecks, fires, and explosions sabotage the Southern Pacific Railroad's Cascades express line and, desperate, the railroad hires the fabled Van Dorn Detective Agency. Van Dorn sends in his best man, and Bell quickly discovers that a mysterious saboteur haunts the hobo jungles of the West, a man known as the Wrecker, who recruits accomplices from the down-and-out to attack the railroad, and then kills them afterward.

It is 1908, and international tensions are mounting as the world plunges toward war. When a brilliant American battleship gun designer dies in a sensational apparent suicide, the man's grief-stricken daughter turns to the legendary Van Dorn Detective Agency to clear her father's name. Van Dorn puts his chief investigator on the case, and Isaac Bell soon realizes that the clues point not to suicide but to murder.