In a residential neighbourhood of Portland, Oregon, an unknown young woman uncovers a shocking crime scene by inexplicably sensing the evil within its walls. To the police, she is a mystery. She can't even tell them her own name. They christen her Jane Doe. Suffering terrifying hallucinations, Jane is assigned to Nathan Fox, a forensic psychiatrist struggling with his own demons. Together they must piece together the jigsaw that is Jane's identity.

Then a sequence of brutal killings terrorizes the city and Fox learns Jane is the only cryptic link between the unrelated victims. To solve the murders, Fox must discard his black and white preconceptions, look beyond the spectrum of normal human experience and confront the dark truth of her past...and his own.