Focusing on the crucial period of 1820 to 1860, Grand Emporium, Mercantile Monster examines the strong economic bonds between the antebellum plantation South and the burgeoning city of New York that resulted from the highly lucrative trade in cotton. In this richly detailed work of literary and cultural history, Ritchie Devon Watson Jr. charts how the partnership brought fantastic wealth to both the South and Gotham during the first half of the nineteenth century. That mutually beneficial alliance also cemented New York's reputation as the northern metropolis most supportive of and hospitable to southerners.

Both parties initially found the commercial and cultural entente advantageous, but their collaboration grew increasingly fraught by the 1840s as rising abolitionist sentiment in the North decried the system of chattel slavery that made possible the mass production of cotton. In an effort to stem the swelling tide of abolitionism, conservative southerners demanded absolute political fealty to their peculiar institution from the city that had profited most from the cotton trade. By 1861, reactionary circles in the South viewed New York's failure to extend such unalloyed validation as the betrayal of an erstwhile ally that in the words of one polemicist deemed Gotham worthy of being "blotted from the list of cities."