Paul Sheldon is a best-selling novelist who has finally met his number-one fan. Her name is Annie Wilkes, and she is more than a rabid reader - she is Paul's nurse, tending his shattered body after an automobile accident. But she is also furious that the author has killed off her favorite character in his latest book. Annie becomes his captor, keeping him prisoner in her isolated house. Annie wants Paul to write a book that brings Misery back to life - just for her. She has a lot of ways to spur him on.

Rosie Daniels leaves her husband, Norman, after 14 years in an abusive marriage. She is determined to lose herself in a place where he won't find her. She'll worry about all the rest later. Alone in a strange city, she begins to make a new life, and good things finally start to happen. Meeting Bill is one, and getting an apartment is another. Still, it's hard for Rosie not to keep looking over her shoulder, and with good reason. Norman is a cop, with the instincts of a predator.

Peaceful suburbia on Poplar Street in Wentworth, Ohio, takes a turn for the ugly when four vans containing armed "regulators" terrorize the street's residents, cold-bloodedly killing anyone foolish enough to step outside their homes. Houses mysteriously transform into log cabins, and the street now ends in what looks like a child's hand-drawn Western landscape. Masterminding this sudden onslaught is the evil creature Tak, who has taken over the body of an autistic eight-year-old boy, Seth Garin.

Andy McGee and Vicky Tomlinson participated in a drug experiment run by a veiled government agency known as The Shop. One year later, they marry. Two years later, their little girl, Charlie, sets her teddy bear on fire by simply staring at it. Now that Charlie is eight, she doesn't start fires anymore. Her parents have taught her to control her pyrokinesis, the ability to set anything - toys, clothes, even people - aflame. But The Shop knows about and wants this pigtailed "ultimate weapon".

Gerald and Jessie Burlingame have gone to their summer home on a warm weekday in October for a romantic getaway. After being handcuffed to her bedposts, Jessie tires of her husband's games, but when Gerald refuses to stop, the evening ends with deadly consequences. Still handcuffed, Jessie is trapped and alone. Over the next 28 hours, in the lakeside house that has become a prison, Jessie will come face to face with all the things she has ever feared.