In this episode of Minding Dementia, we continue our conversation about how Alzheimer’s disease is diagnosed today. While a definitive diagnosis can still only be confirmed through autopsy, modern medical tools now allow physicians to diagnose Alzheimer’s with up to 90% accuracy while a person is living.

Building on our previous discussion about PET scans, this episode walks through the additional diagnostic tools doctors use to better understand cognitive changes and rule out other causes of memory loss.

We discuss how physicians combine:

1. Medical history and neurological exams
2. Neuropsychological testing for memory, language, and problem-solving
3. Blood tests to rule out other conditions
4. Brain imaging such as CT, MRI, and PET scans

No single test can diagnose Alzheimer’s. Accuracy comes from using multiple tools together to build a clearer picture.

We also explore the growing role of biomarkers, measurable indicators found in blood, spinal fluid, and brain imaging that help identify Alzheimer’s-related changes such as beta-amyloid plaques and tau proteins.

In May 2025, the FDA approved Lumipulse, the first blood test to help diagnose Alzheimer’s disease. This test:

1. Is approved for adults 50 and older with early cognitive symptoms
2. Can rule out Alzheimer’s with over 96% accuracy
3. Is less invasive and more affordable than PET scans or spinal taps
4. Is used alongside other diagnostic tools, not as a standalone test

Earlier and more accurate diagnosis allows individuals and families to plan ahead, explore treatment options, access clinical trials, and better understand next steps.

While no test is 100% definitive without autopsy, today’s diagnostic tools provide meaningful clarity and guidance.

Resources

1. Psychology Today – Alzheimer’s Diagnosis Overview https://www.psychologytoday.com/gb/blog/more-than-caregiving/201103/can-alzheimers-disease-only-truly-be-diagnosed-upon-an-autopsy
2. National Institute on Aging – Biomarkers & Dementia https://www.nia.nih.gov/alzheimers
3. Northwestern Medicine – Alzheimer’s Diagnosis https://www.nm.org/neurosciences/alzheimers-disease
4. The Lancet – Alzheimer’s Research https://www.thelancet.com

About the Host:

Author Lisa Skinner is a behavioral specialist with expertise in Alzheimer’s disease and related dementia. In her 30+year...