Unwired: The Lobotomy Legacy

Medicine has always been a little… experimental.
And some ideas refuse to stay buried.

Welcome to The Cadaver’s Lesson, a podcast exploring the strange, fascinating, and unsettling history of medicine. In this episode, we look into one of psychiatry’s darkest chapters: the lobotomy—and how a desperate search for cures led to irreversible harm.

From the pivotal case of Phineas Gage to the rise of psychosurgery in overcrowded mental institutions, we trace how altering the brain became a widely accepted treatment for mental illness. We examine the social pressures, limited medical knowledge, and fear surrounding psychiatric disease that allowed lobotomies to flourish—culminating in Walter Freeman’s transorbital technique, a procedure as fast as it was devastating.

The conversation confronts the human cost of lobotomies: patients stripped of autonomy, families promised miracles, and a medical system that prioritized efficiency over consent and outcomes. We also explore how the introduction of psychiatric medications in the 1950s finally brought about the decline of lobotomies—and what this shift reveals about society’s evolving understanding of mental illness.

By reflecting on the rise and fall of lobotomies, we examine how medicine can be shaped as much by fear and convenience as by science—and why ethical safeguards are essential to progress.

New episodes drop Mondays, with companion historical case episodes on Fridays.
Follow along, stay curious, and remember—
Some lessons were never meant to survive.

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Class is dismissed.

📚 References

• Natale, J. E., & Wolters, P. L. (2013). Violence, mental illness, and the brain – A brief history of psychosurgery: Part 1 – From trephination to lobotomy. Surgical Neurology International, 4, 49. https://doi.org/10.4103/2152-7806.110146
• National Public Radio. (2005, November 16). A lobotomy timeline. https://www.npr.org/2005/11/16/5014576/a-lobotomy-timeline
• International Museum of Surgical Science. (n.d.). Rosemary Kennedy’s lobotomy. https://www.imhm.org/page-1854827
• Ghodse, H., Galea, G., & Volpe, U. (2017). Historical development of psychosurgery. Journal of the History of the Neurosciences. PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510479/
• Andrade, C. (2020). Chapter title if known. In Neurosurgery, Psychiatry, and the Legacy of Lobotomy (Book or Section Title). In StatPearls. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK568715