Vicki Nelson, formerly of Toronto’s homicide unit and now a private detective, witnesses the first of many vicious attacks that begin plaguing the city of Toronto. As death follows unspeakable death, Vicki, in an attempt to stop these forces of dark magic, is forced to renew her relationship with her former partner, Mike Celluci - along with another, unexpected ally…. Henry Fitzroy, the illegitimate son of King Henry VIII, has learned over the course of his life how to blend with humans; how to deny the call for blood in his veins.

For centuries, the werewolves of Toronto have managed to live in peace and tranquility, hidden quietly away on their London, Ontario farm. But now, someone has learned their secret - and is systematically massacring this ancient race. The only one they can turn to is Henry Fitzroy, Toronto-based vampire and writer of bodice rippers. Forced to hide from the light of day, Henry can’t hunt the killer alone so he turns to Vicki Nelson for help.

An evil being has been sealed away for centuries in a sarcophagus never meant to be opened, waiting patiently for his chance to rise again. Now, the seals and spells that imprisoned him chipped away from his discoverers, he has reached forth to claim the minds and souls of Toronto’s unsuspecting citizens. For Henry Fitzroy, it begins with terrifying images of the sun, a marker of death for a vampire. Fearing for his sanity, he turns to his sometimes-lover, private investigator Vicki Taylor, for help.

Vicki Nelson has received the call that no daughter ever wants to receive - that her mother has died. Marjory Nelson’s coworkers at the Queen’s University Life Science Department told her that she suffered a heart attack, and that they’d be waiting for Vicki to arrive in Kingston to make the funeral arrangements. But what begins as a personal tragedy turns into the most terrifying case of Vicki’s career, when her mother’s body disappears mysteriously from the funeral home.

A ghost has invaded Henry Fitzroy's home, beginning a dangerous nightly game in which Henry is allowed to ask a single question. If the answer is no, an innocent person is killed. Henry soon comes to the realization that this wraith is using him to wreak vengeance on the people it holds responsible for its death. Henry can’t find the source of these murders on his own, so he calls on the one person he trusts to help - private investigator Vicki Nelson - with the small hope that they can stop these otherworldly forces.

The Blood books center around three main characters: Vicki Nelson, a homicide cop turned private detective, her former partner Mike Celluci, who is still on the force, and vampire Henry Fitzroy, who is the illegitimate son of Henry VIII and makes his living as a writer of bodice rippers.