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Trials & Tribulations

Trials & Tribulations

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Clinical trials don't run on science alone. They run on people, systems and decisions that almost nobody outside the work ever sees. Michael Sledge, president and chief business officer of the UNC Clinical Research Alliance (CRA) and Dr. John Buse, therapeutic area director at the CRA, talk with investigators, coordinators and staff who build, fund and run trials, and dig into why good studies stall for reasons that have nothing to do with the science.

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  • The Multi-Million Dollar Team Sport
    Oct 15 2026

    Dr. Nick Shaheen returns to look at the system behind individual studies.

    Shaheen, senior associate dean for clinical research at the UNC School of Medicine and director of the North Carolina Translational and Clinical Sciences Institute (NC TraCS), joins Michael Sledge, vice president and chief business officer of the UNC School of Medicine’s Clinical Research Alliance (CRA), and Dr. John Buse.

    They talk through the role NC TraCS and the National Institutes of Health’s Clinical and Translational Science Awards (CTSA) program play in research at UNC, and why the “science of science” matters for making trials better, cheaper and faster.

    Connect with the CRA on LinkedIn: https://www.linkedin.com/company/unc-clinical-research-alliance/

    Learn more about working with the CRA: https://www.med.unc.edu/unccra

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    28 min
  • The Sausage, the Science and the Impact
    Oct 1 2026

    How do raw steaks in a hotel room tie into research on Barrett's Esophagus? Dr. Nick Shaheen has the answer.

    Michael Sledge, vice president and chief business officer of the UNC School of Medicine's Clinical Research Alliance (CRA), and Dr. John Buse start with why clinical trials are so underappreciated. Then Dr. Shaheen, senior associate dean for clinical research at the UNC School of Medicine and Director of the North Carolina Translational and Clinical Sciences Institute (NC TraCS), reflects on his Barrett's esophagus trials.

    Connect with the CRA on LinkedIn: https://www.linkedin.com/company/unc-clinical-research-alliance/

    Learn more about working with the CRA: https://www.med.unc.edu/unccra

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    30 min
  • The Trials & Tribulations Podcast
    Sep 10 2026

    Clinical trials don't run on science alone. They run on people, systems and decisions that almost nobody outside of the work ever sees.

    Michael Sledge, vice president and chief business officer of the UNC Clinical Research Alliance (CRA), and Dr. John Buse talk with investigators, coordinators and staff who build, fund and run them, and dig into why good studies stall for reasons that have nothing to do with the science.

    Connect with the CRA on LinkedIn: https://www.linkedin.com/company/unc-clinical-research-alliance/

    Learn more about working with the CRA: https://www.med.unc.edu/unccra

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    14 min
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