Welcome back to The Metabolic Rebellion. In today's episode, hosts Dr. Brent Brotzman and Kevin Bury go beyond the headlines, the hype, and the celebrity endorsements to reveal the untold story behind GLP-1 agonist weight loss drugs like Ozempic, Wegovy, and Mounjaro. While these medications promise fast and dramatic change, the reality - according to the latest studies and clinical experience - can be far more concerning.

With a clear, candid conversation, they break down why these widely marketed "miracle shots" might offer more risk than reward: from severe muscle and bone loss, to long-term metabolic problems, accelerated aging, and the disturbing reality of increased mortality. Dr. Brent Brotzman explains the hidden mechanism behind what he calls a "pharmacological starvation diet," examining how these drugs can push users into a dangerous cycle of frailty and metabolic decline.

If you've wondered about the deeper physiological impact of GLP-1 drugs, or if you're searching for real, science-based strategies for sustainable weight loss, this episode pulls back the curtain. Join Dr. Brent Brotzman and Kevin Bury as they give you the truth behind the trending treatments, give you hope for lasting change, and arm you with knowledge on how to protect your health for the long run.

Timestamps:

00:00 "GLP-1 Agonist Warnings"

03:30 GLP-1 Risks: Muscle Loss Warning

09:15 Sarcopenia and Muscle Loss Explained

12:17 "Cachexia and Muscle Loss Explained"

15:20 Appetite Suppression and Pleasure Pathway

19:15 "Fat Loss, Not Muscle Loss"

20:52 "The Truth About Weight Loss"

26:08 "Ancestral Diet vs. Weight Loss Drugs"

28:59 "Hidden Costs of Weight Loss"

Opti Metabolics - https://optimetabolics.com/

Show Website - https://themetabolicrebellion.com/

Dr. Brent Brotzman - https://www.linkedin.com/in/dr-brent-brotzman/

Kevin Bury - https://www.linkedin.com/in/kbury/

Podcast Partner - https://tophealth.care/

“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Welcome to The Metabolic Rebellion! In this episode, hosts Dr. Brent Brotzman and Kevin Bury kick off 2026 by taking aim at one of the most entrenched - and misleading - ideas in health and weight loss: the “eat less, move more” mantra. They expose how this slogan, pushed by massive food and beverage companies, has shaped public perception and actually kept us stuck in a cycle of failed diets and frustration.

You’ll hear why calorie restriction - despite decades of popularity - hasn’t solved the obesity epidemic, and why focusing on calories in versus calories out misses the mark when it comes to real human physiology. Dr. Brent Brotzman breaks down the science behind why our bodies aren’t just simple machines and introduces the carbohydrate-insulin paradigm, explaining how the foods we eat affect our hormones, metabolism, and ability to burn fat.

They also highlight how processed foods, artificial sweeteners, and even seemingly “healthy” habits like juicing can undermine weight loss by spiking insulin and making it harder to tap into our fat stores. Plus, they discuss popular trends like GLP-1 medications, and why these might not be the miracle solutions they seem.

If you’re ready to ditch the blame, question broken diet advice, and learn how to truly reclaim your metabolic health, this episode will set the stage for a science-backed, empowering rebellion against outdated weight loss dogma. Tune in and discover how real change starts by thinking - and eating - like your great-great-grandmother.

Timestamps:

00:00 "New Year, Metabolic Revolution"

06:05 The Diet Myth Exposed

09:52 Macronutrients, Blood Sugar, and Hunger

11:47 "Insulin Blocks Fat Burning"

16:25 "Evolution of Eating Habits"

19:21 "Ancestral Eating Habits Explained"

21:25 "Insulin, Fiber, and Weight Loss"

26:01 "GLP-1 Agonists and Muscle Loss"

27:16 "Eat Like Your Ancestors"

Opti Metabolics - https://optimetabolics.com/

Show Website - https://themetabolicrebellion.com/

Dr. Brent Brotzman - https://www.linkedin.com/in/dr-brent-brotzman/

Kevin Bury - https://www.linkedin.com/in/kbury/

Podcast Partner - https://tophealth.care/

“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Welcome back to The Metabolic Rebellion! In this episode, hosts Kevin Bury and Dr. Brent Brotzman are throwing down the gauntlet on one of the biggest health crises you might not even know you’re battling: Insulin Resistance. This isn’t just about blood sugar - it’s the real pandemic driving obesity, type 2 diabetes, Alzheimer’s, heart disease, and so many other chronic conditions affecting a staggering 93% of Americans.

Together, Kevin Bury and Dr. Brent Brotzman dig deep into what insulin resistance actually is, why outdated diet advice like “eat less and move more” has never worked, and how misinformation from the food and pharmaceutical industries keeps us sick. You’ll hear them explain why even “healthy” choices like diet soda or sports drinks can still sabotage your metabolism, and how our modern diets have left our 2-million-year-old pancreases totally unequipped to handle an endless barrage of sugar-laden foods.

If you’re tired of one-size-fits-all weight loss approaches that don’t address the root cause, this foundational conversation is for you. Get ready to learn why prevention is overlooked, how to spot metabolic dysfunction early, and the first steps you can take to start a true metabolic rebellion in your own life.

Timestamps:

00:00 "Frustrations Over Beverage Restrictions"

05:02 "Sugar Beverages Damage Health"

07:28 "Pancreas vs. Modern Diets"

13:03 "Insulin Resistance and Type 2 Diabetes"

14:33 "Ancestral Diet and Metabolic Health"

18:50 Sugar Intake and Health Risks

21:54 Obesity, Insulin, and Cancer Connection

26:00 "Brain Health Tied to Insulin"

26:43 Ketones and Brain Aging Prevention

30:31 "Challenging the Calories In/Out Myth"

35:15 "Caloric Restriction's Long-Term Failure"

36:51 "Debunking Myths: Lower Insulin Now"

41:06 Foundational Nutrition & Upcoming Topics

43:14 "Understanding Physiology for Weight Control"

Opti Metabolics - https://optimetabolics.com/

Show Website - https://themetabolicrebellion.com/

Dr. Brent Brotzman - https://www.linkedin.com/in/dr-brent-brotzman/

Kevin Bury - https://www.linkedin.com/in/kbury/

Podcast Partner - https://tophealth.care/

“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”