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The GP Show

The GP Show

Von: Dr Sam Manger
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Join GP Dr Sam Manger and special guests from around the World discussing the latest in evidence-based medicine and more. This podcast is designed-with-love for medical doctors, scientists, researchers, allied health, nurses, students and anybody else interested in health, science and medicine.Dr Sam Manger Hygiene & gesundes Leben
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  • #222 Perimenopausal Mental Health with Professor Jayashri Kulkarni

    #222 Perimenopausal Mental Health with Professor Jayashri Kulkarni
    Jul 7 2026
    Professor Jayashri Kulkarni is one of Australia's leading psychiatrists and researchers specialising in women's mental health. She is the Director of the HER Centre Australia (Health, Education and Research for Women's Mental Health) and Professor of Psychiatry at Monash University. Professor Kulkarni's work focuses on mood disorders across the female lifespan, with particular attention to the neurochemical effects of reproductive hormones on brain function, including perimenopausal depression and premenstrual dysphoric disorder. She is the developer of the Meno-D rating scale and has been a leading voice for over four decades in the recognition and treatment of hormone-related mental illness in women. In this episode, Dr. Ashlea Broomfield speaks with Professor Jayashri Kulkarni about the mental health impact of perimenopause. They discuss the role of oestrogen and progesterone as neurosteroids influencing mood, cognition, and behaviour; why mood symptoms often precede vasomotor changes by years; which women are most at risk and why; the distinct clinical profile of perimenopausal depression and how to avoid common misdiagnoses; and how to approach hormonal treatment in practice (including contraceptive options, transdermal oestradiol, micronised progesterone, and tibolone) alongside a review of the evidence around MHT safety. RESOURCES "The primary care management of perimenopausal depression" — Kulkarni J et al. Australian Journal of General Practice 2026;55(4). Read here HER Centre Australia — Research, clinical resources, and the Meno-D scale: monash.edu/medicine/her-centre Meno-D rating scale — Available via HER Centre Australia and as an appendix in the AJGP article above Healthy Hormones — GP-led community, resources, and webinars: healthyhormones.au Australasian Menopause Society — Evidence-based guidelines and resources: menopause.org.au Monash University women's mental health short course — Via HER Centre Australia ( PMDD companion episode — The GP Show with Professor Jayashri Kulkarni (link once live) Fast Facts in Sexual and Reproductive Health with Dr. Sara Whitburn — The GP Show TIMESTAMPS 00:00 — Introduction, Welcome to Country, guest bio 03:40 — Reproductive hormones as brain neurosteroids: neurochemical effects of oestrogen and progesterone across the perimenopausal transition 12:19 — Risk factors for perimenopausal mood sensitivity: early life trauma, the HPA/HPG axis, and recognising hormonal sensitivity in clinical history 24:28 — Diagnostic considerations: the Meno-D scale, distinguishing perimenopausal depression from MDD and bipolar disorder, and current gaps in psychiatric classification 37:29 — MHT safety: reviewing the 2001 WHI study, absolute and relative contraindications, and monitoring in practice 45:33 — Treatment approaches: hormonal contraception, transdermal oestradiol, micronised progesterone, tibolone, and tailoring to the individual 59:16 — Further resources and preview of the PMDD companion episode ... If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app. If you would like to request a topic, please contact us via contact@thegpshow.com Thank you for listening and your support. ... Study and learn lifestyle medicine: Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science? Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine. Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.
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    1 Std. und 2 Min.
  • #221 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MECFS) with Dr David Fineberg

    #221 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MECFS) with Dr David Fineberg
    Jun 22 2026

    Dr David Fineberg is a General Practitioner and PhD candidate at the University of Melbourne whose research focuses on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID. He is the founding clinician of the ME Research Clinic (MERC), a translational research hub dedicated to advancing the diagnosis, evaluation, and treatment of complex post-viral syndromes through an evidence-based, patient-centred model. His PhD is "Precision Medicine techniques In the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS + Long Covid (PRIME)".

    Episodes resources:

    1. MECFS diagnostic criteria from ME Research UK
    2. DePaul Questionnaire
    3. FUNCAP (Functional Capacity) Questionnaire
    4. Open Medicine Foundation Resources and Clinical Guidelines
    5. Visible App - wearable tech for illness, not wellness, designed for MECFS, POTS, EDS and Long Covid
    6. RACGP Energy Limiting Disorders SIG and CPD CHECK

    ...

    If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app.

    If you would like to request a topic, please contact us via contact@thegpshow.com

    Thank you for listening and your support.

    ...

    Study and learn lifestyle medicine: Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science? Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine.

    Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine

    The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.

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    1 Std. und 16 Min.
  • #220 Loose Joints, Lax Ligaments, and Liquid Gold: Musculoskeletal Medicine for Hypermobility with Dr Rob Illingworth

    #220 Loose Joints, Lax Ligaments, and Liquid Gold: Musculoskeletal Medicine for Hypermobility with Dr Rob Illingworth
    Jun 4 2026

    Many of us have patients with hypermobility and Ehlers-Danlos syndrome who we work hard to help. As our understanding of these complex multisystem conditions grows, understanding that it doesn't just affect joints but potentially autonomic function, cardiovascular health, digestion, and producing widespread, often debilitating pain, so too does the need for a broader range of therapeutic options.

    In this episode, musculoskeletal medicine specialist Dr. Rob Illingworth introduces prolotherapy and PRP as practical, evidence-informed options that could make a real difference to your patients' quality of life and function.

    For anyone managing patients with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorders, this one's essential. Dr. Illingworth unpacks the "perfect storm" of lax connective tissue, sensitized pain pathways, and complex comorbidities and adds a valuable option to your therapeutic toolkit for people presenting with these complex conditions.

    ...

    If you find this podcast valuable, please help but rating the podcast 5 stars and leaving a review in your podcast app.

    If you would like to request a topic, please contact us via contact@thegpshow.com

    Thank you for listening and your support.

    ...

    Study and learn lifestyle medicine: Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science? Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine.

    Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine

    The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.

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    1 Std.
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