Pig Kidney Transplants: The 2025 Breakthrough That Changed Everything
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Pig Kidney Transplants: The 2025 Breakthrough That Changed Everything
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In 2025, we crossed a historic threshold. Multiple humans survived more than six months with gene-edited pig kidneys functioning inside them, in both the United States and China.
For the 100,000 Americans waiting for a kidney right now, this matters.
In this episode, I break down:
- What actually happened with the Massachusetts General Hospital patient who lived 271 days with a pig kidney
- Why is six months the critical survival benchmark in transplantation
- The 69 gene edits that made these kidneys human-compatible
- What the 2024 animal studies predicted — and how human data confirmed it
- The formal clinical trials now underway
- What still stands in the way: rejection, infection risk, and limited access
This is not a cure. Pig kidneys still require lifelong immunosuppression. But for patients who have run out of options — older dialysis patients, highly sensitized patients, those without living donors — this is the first real alternative we have seen in decades.
I give you my honest assessment of where xenotransplantation stands today.
Dr. Sean Hashmi is a board-certified Nephrologist and Obesity Medicine Specialist.
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