Unsaid is told from the perspective of Helena Colden, a veterinarian who has just died of breast cancer. Helena is forced to witness the rapid emotional deterioration of her husband, David. With Helena's passing, David, a successful Manhattan attorney, loses the only connection that made his life full. He tries to carry on the life that Helena had created for them, but he is too grief-stricken, too angry, and too quickly reabsorbed into the demands of his career. Helena's animals likewise struggle with the loss of their understanding and compassionate human companion.

Because of Helena, David becomes involved in a court case to save the life of a chimpanzee that may hold the key to unlocking the mysteries of animals consciousness. Through this case all the threads of Helena's life entwine and explode - unexpectedly, painfully, beautifully.