Special Agent Smoky Barrett has been to hell and back - her husband and child were murdered years ago - and now a serial killer who calls himself "The Preacher" wants to teach her a lesson about divinity. A high-profile politician's daughter is killed mid-flight on her way to Washington, DC, and the only clue is a silver cross that has been left in her side.

This was to be her last day alive. The renowned criminal psychologist Ira Samin prepared her suicide thoroughly. The death of her eldest daughter had weighed too heavily on her conscience for her to carry on and she yearned for one last drink to raise a toast to oblivion. Her morbid plans are interrupted and she is called in to negotiate a gruesome hostage situation at a radio station where a psychopath is playing a morbid game.

When the body of a young woman is discovered in a derelict cottage in the middle of Los Angeles National Forest, Homicide Detective Robert Hunter finds himself entering a horrific and recurring nightmare. Naked, strung from two wooden posts, the victim was sadistically tortured before meeting an excruciatingly painful death. All the skin has been ripped from her face - while she was still alive.

Taken from a group home at age 12, Evan Smoak was raised and trained as part of the Orphan Program, an off-the-books operation designed to create deniable intelligence assets - i.e. assassins. Evan was Orphan X. He broke with the Program, using everything he learned to disappear and reinvent himself as the Nowhere Man, a man who helps the truly desperate when no one else can. But now Evan's past in the Orphan Program is reaching out to him. 

After an overhaul of leadership at the FBI's New York field office, A. X. L. Pendergast is abruptly forced to accept an unthinkable condition of continued employment: the famously rogue agent must now work with a partner. Pendergast and his new teammate, junior agent Coldmoon, are assigned to Miami Beach, where a rash of killings by a bloodthirsty psychopath are distinguished by a confounding M.O.: cutting out the hearts of his victims and leaving them - along with cryptic handwritten letters - at local gravestones, unconnected save in one bizarre way.