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Within the mysteries of the body, especially those who have been murdered, 18th-century anatomist Dr. Thomas Silkstone specializes in uncovering the telltale clues that lead toward justice.
Newly released from the notorious asylum known as Bedlam, Lady Lydia Farrell finds herself in an equally terrifying position - as a murder suspect - when she stumbles upon the mutilated body of Sir Montagu Malthus in his study at Boughton Hall.
Meanwhile, Dr. Thomas Silkstone has been injured in a duel with a man who may or may not have committed the grisly deed of which Lydia is accused. Despite his injury, Thomas hopes to clear his beloved's good name by conducting a postmortem on the victim. With a bit of detective work, he learns that Montagu's throat was slit by no ordinary blade, rather a ceremonial Sikh dagger from India that may be connected to the fabled lost mines of Golconda.
From the mysterious disappearance of a cursed diamond buried with Lydia's dead husband to the undying legend of a hidden treasure map, Thomas must follow a trail of foreign dignitaries, royal agents, and even more victims to unveil the sinister and shocking secrets in the stones.