Meg Kirkland fears her impudent tongue has caused her father's dismissal from his job and forced her whole family from their home on Middleditch Farm. Worse still, her father abandons them outside the workhouse, leaving Meg to care for her devastated mother, Sarah, and little brother as tragedy continues to haunt the family.

Emily Ryan has gone up in the world since her arrival in Sheffield. Brought there by her mother's ambitious schemes for her brother, Josh, she had found work as a buffer girl polishing cutlery for the city's famous trade. With the help of a friend, Nell, Emily eventually set up her own buffing business, employing those with whom she had once worked. Married to Thomas Trippet - Trip to his friends - they plan to build a life together, but when Lucy, Nell's daughter, disappears, it seems that the menace from the past is never very far away.

It is the early 1920s, and the Maitland family are still coming to terms with the aftermath of the Great War. After her brave work as an ambulance driver and nurse close to the Front, Pips is restless and without purpose. Determined to enjoy life after the years of misery, and to help her forget a broken love affair, she seeks excitement in the London parties and balls of the Roaring '20s. No family or community escaped the ravages of this war, and Pips knows her own has its share of troubles.

Thwarted in her desire to become a doctor like her brother, Robert, Pips Maitland rebels against her mother's wishes that she settle down and raise children. However, when Robert brings home a friend from medical school, Giles Kendall, it seems perhaps Pips might fall in love with an acceptable suitor after all. But the year is 1914, and the future is uncertain. Hearing that her father's friend, Dr John Hazelwood, is forming a flying ambulance corps to take to the front lines, Pips is determined to become one of its nurses and asks Alice Dawson, her maid, to go with her.

Two very different girls from this tight-knit community join up as ARP Wardens to do their bit for the home front. Violet Simms lives with her controlling, widowed mother who runs the local pawn shop. At just 20-years-old, Violet longs for friendship, love and escape. It seems her dreams might come true until tragedy strikes on one of the very worst nights of the Birmingham Blitz. Grace Templeton is the eldest in her family of 10 children. Spirited Grace is determined never to become burdened by child bearing and drudgery like her mother. 

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.

Bobbie Fraser, Mary Holland and Jean Thornton are Atta Girls - part of the Air Transport Auxiliary team flying planes between bases. Taking to the air in anything they're given, their work is dangerous but their courage always comes through. Now there's a new girl joining the ranks - Canadian Viv Robertson, who is bright, brash and brave. But can Viv settle into her new home with the other girls? 

It is two years since Harpers opened in Oxford Street and Ben is planning to expand the premises. Life is good for Sally and Ben as they look forward to their first child and hope for a prosperous future. Beth is settling into married life with Jack, gradually recovering from her aunt’s tragic death, though still unable to conceive a child. New girls have joined Harpers and Marion, Janice and Becky all become a part of the daily life at the busy store. Rachel is undecided whether to marry a man she isn’t sure she can trust, while Minnie meets an old love.

Rosalind and her husband, Paul, move from Australia to England due to his job with a multinational company. But Paul is called away to deal with a crisis in Hong Kong, and Rosalind is left to settle in a new country on her own. One by one her three grown children need help, and there is only Rosalind available, because as usual Paul puts his job first. When she finds out that her husband has been unfaithful for years, it appears to be the final blow to their marriage, especially as she has met another man. 

Summer 1942. Despite grim reports on the wireless and rationing hitting hard, Lily Collins and her fellow shop girls from Marlow’s department store are determined to put out the bunting for a family party. But Beryl’s husband, Les, returns from North Africa a changed man, and Gladys worries for her own fiancé’s safety. The store is losing staff to the war effort, and Lily’s young man, Jim, is torn over where his duty lies. Then comes the knock on the door that everyone dreads. Lily’s family, always the heart of her world, is rocked to the core. 

Hull, 1940. Widowed Edie Copeland has just arrived on Exchange Street, heavily pregnant and with heavy suitcase in tow. She left York after tragedy struck to make a fresh start, but she's a stranger to this street, and her new landlord doesn't hesitate to remind her of this, widow or not. Luckily, the neighbours are a little more welcoming and Edie is soon made to feel at home by the Maguires and the Scuttles. As air raids sound and the war feels closer than ever, the community has to stick together. But Edie is hiding something, and she doesn't know how much longer her secret is safe.

Mary is a driver for the ATA and although she yearns to fly a Spitfire, she fears her humble background will hold her back. After all, glamorous Angela is set to be the next ‘Atta Girl’ on recruitment posters. Bobbie learned to fly in her father’s private plane, and Jean was taught the queen’s English at grammar school before joining the squad. Dedicated and resilient, the three girls rule the skies: weathering storms and dodging enemy fire. Mary can only dream of joining them - until she gets the push she needs to overcome her self-doubt. 

Sunderland, 1943: With the future of Britain so uncertain, the women are trying to keep their lives at home on an even keel. Only by rallying together will the shipyard girls finally triumph.  

For most of her life, Judy Begg has been a loyal servant at Creek Manor and to Jack Fox, its future lord. But just as their childhood friendship blossoms into a secret engagement he abandons her to join his brother overseas. And with Creek Manor up for sale, Judy and her family lose everything. Devastated, Judy is nonetheless determined to make the best of her life. Resolving to forget about Jack, she battles to keep her family from poverty’s door and her mother from the hands of her violent husband.

The shop girls of Harpers Emporium on Oxford Street are happy in their work, and their lives are moving on at quite a pace. United by the suffragette cause and now living under one roof, some will find love and marriage whilst others experience heartache and tears. Harpers is the bond that holds them together, bringing strength through hardship and pain and friendship and love.