Bela and Lizzy, the dominant megalodon siblings from Angel's brood, have escaped the Tanaka Institute to roam the Salish Sea in British Columbia. While Jonas Taylor and his friend Mac attempt to either recapture or kill the "sisters," Jonas' son, David, embarks on his own adventure, motivated by revenge. Having witnessed his girlfriend's gruesome death, David has joined a Dubai prince's ocean expedition, tracking the 120-foot, hundred-ton Liopleurodon that escaped from the Panthalassa Sea.

Eighteen years have passed since Jonas Taylor last crossed paths with Carcharodon megalodon. Now a middle-aged father of two, he is overwhelmed by mountains of bills and the daily strife of raising a family. But life is about to change. A Hollywood television producer wants Jonas to join his new survival series: Daredevils. For the next six weeks, two teams of crazy daredevils on a South Pacific Ocean voyage will try to outperform one another in front of the cameras.

Book six in the best-selling Meg series picks up after Meg: Nightstalkers with David Taylor in the Salish sea, attempting to locate and rescue any surviving Megalodon pups before a local fisherman slaughters them. Meanwhile, Jonas is coerced into joining an expedition into the Panthalassa sea in search of a prehistoric predatory species possessing liver enzymes that can cure cancer.

East Antarctica: the coldest, most desolate location on earth. Two-and-a-half miles below the ice cap is Vostok, a 6,000 square mile liquid lake, over 1,000 feet deep, left untouched for more than 15 million years. Now, marine biologist Zachary Wallace and two other scientists aboard a submersible tethered to a laser will journey 13,000 feet beneath the ice into this unexplored realm to discover Mesozoic life-forms long believed extinct - and an object of immense power responsible for the evolution of modern man.

Its appetite is ravenous. Its teeth scalpel-sharp. Its power unstoppable as it smashes the steel doors holding it in a Monterey, California, aquarium. The captive 20-ton Megalodon shark has tasted human blood, and it wants more.