Dr. Jason Kunik is working on the most earth-shattering genetics project ever: DNA mapping of a new species, the quickened - dogs who can shift into human form. The problem is, no one knows the quickened exist, and Jason can't betray them by publishing his studies. When he moves to Mad Creek to continue his research in a town full of quickened, all he wants is peace, quiet, and to be allowed to bury himself in his work. Perhaps if he figures out how the mutation is activated, he can silence his own inner dog forever.

Milo is a hospice comfort dog who has bonded with, and lost, many beloved patients in his life. He intuitively understands sickness and pain on a spiritual level most can't see. When he gains the ability to become a man, he thinks he finally has everything he ever wanted. But being a man isn't the same thing as being loved, and taking shelter in Mad Creek isn't the same thing as finding a home.

When a mysterious illness hits Mad Creek and threatens all the quickened in town, it's up to the scientist and the comfort dog to figure out what it is and how to stop it. Along the way they might discover that true love is possible - if you wish upon a star.