Once a proud Senator in imperial Rome, kidnapped and made a "blood god" by the Druids, Marius becomes the embittered protector of Akasha and Enkil, Queen and King of the vampires, in whom the core of the supernatural race resides. We follow him through his heartbreaking abandonment of the vampire Pandora. Through him we see the fall of pagan Rome to the Emperor Constantine and the horrific sack of the Eternal City itself at the hands of the Visigoths. Bravely, Marius seeks a new civilization in the midst of glittering Constantinople, only to meet with the blood drinker Eudoxia. We see him ultimately returning to his beloved Italy, where after the horrors of the Black Death he is restored by the beauty of the Renaissance. We see him become a painter living dangerously yet happily among mortals, giving his heart to the great Botticelli, to the bewitching courtesan Bianca, and to the mysterious young apprentice Armand.

Moving from Rome to Florence, Venice, and Dresden, and to the English castle of the secret scholarly order of the Talamasca, the novel reaches its dramatic finale in our own time, deep in the jungle where Marius, having told his life story, seeks some measure of justice from the oldest vampires in the world.